A sensor implantation assembly is disclosed that includes a tissue puncture closure device. The tissue puncture closure device has a proximal end portion and a distal end portion and a suture extending from the proximal end portion to the distal end portion. A suture anchor assembly is also included that is insertable through a tissue wall puncture. The suture anchor assembly is attached to the suture at the distal end portion of the closure device and has a diagnostic sensor. A sealing pad is positioned around the suture at the distal end portion and is slidable along the suture. The diagnostic sensor may be placed within a tissue wall to gather diagnostic information such as pressure measurements at or near the site of the tissue puncture closure.

A subcutaneously implantable device includes a housing, a clip attached to the housing, and an electrode. The clip is configured to move between an open position and a closed position to increase or decrease an opening between the housing and the clip to anchor the device to a muscle, a bone, and/or a first tissue. The electrode is configured to contact an organ, a nerve, the first tissue, and/or a second tissue. Circuitry in the housing is in electrical communication with the electrode and is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ, the nerve, the first tissue, and/or the second tissue.

Embodiments provide an apparatus, system, kit and method for in vivo measurement of blood oxygen saturation (BAS). One embodiment provides an implantable apparatus for measuring BAS comprising a housing, emitter, detector, processor and power source. The housing is configured to be injected through a tissue penetrating device into a target tissue site (TS). The emitter is configured to emit light into the TS to measure BAS, the emitted light having at least one wavelength (LOW) whose absorbance is related to a BAS. The detector is configured to receive light reflected from the TS, detect light at the LOW and generate a detector output signal (DOS) responsive to an intensity of the detected light. The processor is operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the DOS and includes logic for calculating a BAS and generate a signal encoding the BAS.

A first embodiment of the implantable real-time oximeter of the present invention is attached around a blood vessel near the site of a likely stroke to monitor large and medium size cerebral arteries. Another embodiment of the implantable real-time oximeter can be passed within cerebral blood vessels to monitor the oxygenation status of the surrounding cerebral tissues. When used within cerebral blood vessels, the emitter and detector are coplanar and contained in a small area, for example, 50-120 m.

There is provided an implantable pressure monitor having a fluid sack in contact with a body part of a patient where the fluid sack is retained to the body part by a pressure monitor housing that may have various attachment means. The fluid sack is filled with a liquid such as silicone oil. The pressure monitor housing has an opening that provides access to a fistula with a fluid valve that terminates through the fluid sack. A fiber optic pressure sensor is in contact with the liquid in the fluid sack by way of the fistula and fluid valve. In some embodiments of the present invention, an electronics module is incorporated with the implantable pressure monitor to provide telemetry, power, and the like.

A delivery and fixation system of an implant assembly having an intracorporeal device. The system provides for a low profile delivery system for an implant assembly having an anchor for fixation within a vessel adapted to be delivered via a catheter.

Implant (e.g., sensory implant) positionable within subject's left heart atrium, for facilitating functional activity thereof, such as sensing or/and measuring physiological conditions or/and parameters. Implant includes: implant body housing physiological parameter sensing or/and measuring means; coupling means for coupling with an implant deployment device; and septum gripper having a flexible gripping sleeve fixedly connected to implant body wall, and selectively shapeable to pass through organ wall septum opening, and for gripping onto organ wall, such that implant body is fixatable or/and stabilizable across organ wall and through septum opening, to facilitate sensing or/and measuring in subject's body organ. Also disclosed are: a system including the implant, a process control unit, and a transcatheter implant deployment device; and an implant for implantation in subject's body organ separated by an organ wall, and configured for inductive coupling with electronic unit located outside subject's body and for interactively communicating with electronic unit.

Embodiments provide an apparatus, system, kit and method for in vivo measurement of blood oxygen saturation (BAS). One embodiment provides an implantable apparatus for measuring BAS comprising a housing, emitter, detector, processor and power source. The housing is configured to be injected through a tissue penetrating device into a target tissue site (TS). The emitter is configured to emit light into the TS to measure BAS, the emitted light having at least one wavelength (LOW) whose absorbance is related to a BAS. The detector is configured to receive light reflected from the TS, detect light at the LOW and generate a detector output signal (DOS) responsive to an intensity of the detected light. The processor is operably coupled to the detector and emitter to send signals to the emitter to emit light and receive the DOS and includes logic for calculating a BAS and generate a signal encoding the BAS.

Implant deployment device for delivering and deploying an implant. Includes: deployment device body for pushing implant in subject's blood vessel, across an interatrial septum and into subject's heart left atrium; and a handle operatively connected to deployment device and having controls assigned to selectively operate positioning of the deployment device, to facilitate determining compression extent of an implant body, and detaching of deployment device from the implant. Also disclosed are: a method for fixating an elongated implant across an organ wall in a subject's body, and a method for sealing a wall opening in a septal wall in a subject's body.

A surgical system used to determine a size of a vessel within a region proximate to a working end of a surgical instrument includes at least one light emitter disposed at the working end, an array of light sensors disposed opposite the at least one light emitter, the array comprising a least one row of light sensors, individual light sensors in the row adapted to generate a signal comprising a pulsatile and a non-pulsatile component, and a controller coupled to the array, the controller comprising a splitter to separate the pulsatile component from the non-pulsatile component, and an analyzer to determine the magnitudes of the pulsatile and non-pulsatile components at the individual light sensors, to determine a first peak magnitude and a second peak magnitude of the pulsatile components, and to determine a resting outer diameter of the vessel based on the first and second peak magnitudes.