A method of determining atrial fibrillation includes determining if a patient's pulse beats form an irregular pattern. If so, presence of an irregular pulse is indicated to a patient and, an electrocardiogram is obtained for determining atrial fibrillation. Initially, a pulse is detected at regular time intervals from a first appendage when motionless, using a pulse detector and pulse rhythms from a succession of time intervals, each corresponding to a respective interval of time between successive pulse beats of a sequence of the pulse beats. Then, a second appendage makes contact with an electrically conductive unit, and electrocardiogram signals are detected simultaneously with pulse rhythms while the first appendage is motionless and both appendages are relaxed. The signals are then analyzed to determine whether, in combination, they are indicative of atrial fibrillation. If atrial fibrillation is determined not to be present based on analysis of said ECG, then the pulse analyzer is adjusted to not detect that pulse pattern as irregular.

A system uses continuous tracking of sleep activity and heart rate activity to evaluate heart rate variability immediately before transitioning to an awake state, e.g., at the end of the last phase of deep sleep. In particular, a wearable, continuous physiological monitoring system as described herein includes one or more sensors to detect sleep states, the transitions between sleep states, and the transitions from a sleep state to an awake state for a user. This information can be used in conjunction with continuously monitored heart rate data to calculate heart rate variability of the user at the end of the last phase of sleep preceding the user waking up. By using the history of heart rate data in conjunction with sleep activity in this manner, an accurate and consistent recovery score can be calculated based on heart rate variability.

A monitor comprises circuitry to receive a signal and process the signal to monitor at least one characteristic of a subject, and a flexible polymer casing forming a waterproof enclosure for the circuitry. The flexible polymer casing is infused with a conductive material at at least one location to form at least one infused electrode that extends from an exterior of the flexible polymer casing to an interior of the flexible polymer casing, and the at least one infused electrode is coupled to the circuitry so as to allow the signal to pass from outside the flexible polymer casing to the circuitry. A polymer in a portion of the flexible polymer casing that is infused with the conductive material at the at least one location is cross-linked with a polymer in a portion of the flexible polymer casing that is not infused with the conductive material.

The present disclosure provides a vital sign measuring device and method that may measure a heart rate signal of a living body in a motion state. The method comprises detecting two different signals, using an adaptive noise removal algorithm for removing noise from the two signals, and obtaining a more accurate heat rate signal after a certain operation.

The present application in some embodiments relates to methods for reducing noise and/or clutter when measuring a spectrum, particularly but not only for OCT imaging. In some embodiments a light source is synchronized with a detector. For example a narrow band light source is synchronized with a narrow band detector. For example, the light source may scan over multiple frequency bands and/or the detector may be tuned to a frequency band synergetic to the band of the light source. For example the light source and detector may be tuned to overlapping narrow bands. Optionally the detector has a sensor set for each frequency band. Optionally some sensor sets are individually resettable. For example each set may have a reset circuit. For example, a sensor set for a band not currently being measured is deactivated.

A method of controlling a device located in a predetermined space includes: obtaining sleep information of a person present in a first space from a biological sensor disposed in the first space, the sleep information indicating a sleep state of the person and the first space includes a first device; determining, by a processor, a first sound volume to be set for the first device based on a first database indicating a correspondence between the sleep state and a target sound volume of a corresponding device, the target sound volume of the corresponding device being a predetermined sound volume which does not awake a sleeping person at the sleep state and still be heard by an awake person; and transmitting, to the first device, a first command for setting the first sound volume in the first device as a sound volume upper-limit value.

The present invention relates to a device, system and method for determining physiological information indicative of at least one vital sign of a subject. The device comprises a pulse signal computation unit (132) configured to compute a pulse signal (211) from at least three detection signals (210), wherein at least one of the detection signals comprises wavelength-dependent reflection or transmission information in a wavelength channel below 600 nm. A processing unit (133) derives physiological information (212) indicative of at least one vital sign from a part of said signature vector represented by vector coefficients that reflect pulsatilities of the detection signals comprising wavelength-dependent reflection or transmission information only in wavelength channels above 600 nm.

Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

A method of detecting neural activity in a nerve is disclosed. A first electrical signal is received from a first pair of electrodes. A second electrical signal is received from a second pair of electrodes, the second pair of electrodes being spaced from the first pair of electrodes along the nerve. A correlation analysis is applied between the first and second electrical signals, including for at least one non-zero lag time, to obtain correlation data. From the correlation data, at least one neural signal is detected, indicative of neural activity in the nerve. The neural signal corresponds to increased correlation between the first and second signals at the at least one non-zero lag time.

This disclosure provides cascaded reference circuits and low amplitude signal sensing circuits that are useful in wearable devices. Circuits for measuring electrovesselgram (EVG) and subdermal spectrogram (SSG) are provided, as well as methods for using these circuits to determine quantities and qualities of a person's moods, such as how much and what kinds of stress they experience. The provided devices are useful on limbs and appendages, such as in a smart watch that is worn on the wrist. Methods are provided for using the devices of this disclosure to privately alert wearers to an increase in bad stress in the moment when they can take actions to reduce their stress and physiological stress responses. These devices are useful for measuring and increasing the effectiveness of relaxation techniques. As a result of using methods and devices of this disclosure, people are healthier, they make more response-able decisions, and relationships improve.