A time sequenced series of optical images of a patient is obtained at a rate faster than cardiac frequency, wherein the time sequenced series of images capture one or more physical properties of intrinsic contrast. A cross-correland signal from the patient is obtained. A cross-correlated wavelet transform analysis is applied to the time sequenced series of optical images to yield a spatiotemporal representation of cardiac frequency phenomena. The cross-correlated wavelet transform analysis comprises performing a wavelet transform on the time-sequenced series of optical images to obtain a wavelet transformed signal, cross-correlating the wavelet transformed signal with the cross-correland signal to obtain a cross-correlated signal, filtering the cross-correlated signal at cardiac frequency to obtain a filtered signal, and performing an inverse wavelet transform on the filtered signal to obtain a spatiotemporal representation of the time sequenced series of optical images. Images of the cardiac frequency phenomena are generated.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

A method implemented on a computing device having at least one processor, storage, and a communication platform connected to a network for determining blood pressure may include: receiving a request to determine blood pressure of a first subject from a terminal, obtaining data related to heart activity of the first subject, determining a personalized model for predicting blood pressure with respect to the first subject, determining the blood pressure of the first subject using the personalized model based on the data related to heart activity of the first subject, and sending the blood pressure of the first subject to the terminal in response to the request.

The process for classifying anesthetic depth includes: collecting of biological signals, conditioning of said signals, monitoring of activity of the central and autonomic systems, measurement of indexes and classification of patterns in anesthetic depth. The activity includes: i) Awake: Vigil—Ak. and recovery of verbal response—Rc. ii) Light Anesthesia: Light induction anesthesia—Li. Light recovery—Lr, Light dose, increase in drugs or patient movement (La), iii) General anesthesia: General anesthesia—Ga, one minute after the start of the surgery, and iv) Deep anesthesia: identification of the EEG burst-suppression pattern (BSP) associated with deep anesthesia.

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject.

A computer-implemented method for contact photoplethysmography, abbreviated contact PPG, comprises obtaining during a time interval plural PPG signals for sub-regions of a lens or video frame; and combining the plural PPG signals to thereby obtain a multi-region PPG signal.

A motion data processing method and a motion monitoring system provided in the present disclosure may process an electromyography (EMG) signal in the frequency domain or time domain to identify an abnormal signal in the EMG signal, such as an abrupt signal, a missing signal, a saturation signal, an oscillation signal, etc. caused by a high-pass filtering algorithm. The motion data processing method and the motion monitoring system may further perform a data sampling operation on the EMG signal through a data sampling algorithm, and predict data corresponding to the time point when the abnormal signal appears based on the sampling data, so as to obtain prediction data, and replace the abnormal signal by using the prediction data to correct the abnormal signal. The motion data processing method and the motion monitoring system may not merely accurately identify the abnormal signal, but further correct the abnormal signal, so that the corrected data may be more in line with an actual motion of a user, thereby improving user experience.

Systems, methods and implantable devices configured to provide cardiac resynchronization therapy and/or bradycardia pacing therapy. A first device located in the heart of the patient is configured to receive a communication from a second device and deliver a pacing therapy in response to or in accordance with the received communication. A second device located elsewhere is configured to determine an atrial event has occurred and communicate to the first device to trigger the pacing therapy. The second device may be configured for sensing the atrial event by the use of vector selection and atrial event windowing, among other enhancements. Exception cases are discussed and handled as well.

This disclosure relates generally to patient invariant model for freezing of gait detection based on empirical wavelet decomposition. The method receives a motion data from an accelerometer sensor coupled to an ankle of a subject. The motion data is further processed to denoise a plurality of data windows using a peak detection technique to classify into a real motion data window or a noisy data window. Further, a plurality of denoised data windows are generated by processing spectrums associated with each real motion data window and a plurality of empirical modes using an empirical wavelet decomposition technique (EWT). Then, a resultant acceleration is computed, and a plurality of features are extracted from the denoised data window which enables detection of freezing of gait based on a pretrained classifier model into a (i) a positive class, or (ii) a negative class.

A biological information measuring device comprises: a plurality of sensors that each acquire a base signal containing biological information and noise information; and a processing device that acquires biological information on the basis of a plurality of base signals. The processing device comprises: a component analysis part that performs a prescribed component analysis on the basis of the plurality of base signals and generates a plurality of component signals which constitute the plurality of base signals; and a biological information acquisition part that determines whether a component signal is biological information.