The present disclosure provides a pharmaceutical composition for multi-stage release of psychoactive substances including cannabinoids. The pharmaceutical composition comprises two or more staged compositions having different release profiles or different release time such that the one or more active agents in each of the two or more staged compositions are released into the subject's blood stream at different time points.

Computer implemented biometric methods and systems incorporate sensing biophysical phenomena, translating the phenomena into digital data and transmitting the data to a series of servers operating in an open feedback loop to generate a module. A biometric networking system can include a biometric monitoring cloud computing platform with AI/machine learning augmented models are generated to make user assessments, programs and confidence scores to the healthcare provider systems. The AI/machine learning models can be used by the biometric monitoring network to generate health-related AI processes that analyze relationships treatment techniques and outcomes. AI techniques can be used to calculate movement modeling and confidence scoring including support vector machines, neural networks, and decision trees. The biophysical phenomena may include biometric parameters based on data, such as medical history, exertion, sleep, temperature, cardiovascular events, respiratory events, and muscle and blood pH.

A method of determining a likelihood that a debt payment will be made or received, the method comprising sending a message to a debtor mobile computing device comprising a link to a debtor portal; displaying on the debtor mobile computing device an indication of the debt owing; displaying on the debtor mobile computing device a proposed payment plan for settlement of the debt; and receiving an indication that the debtor accepts the proposed payment plan is disclosed. The method may use Next Best Action (NBA) modelling. The message sent may be a SMS message and it may include an indication of the debt owing. The method may further comprise offering a discount to the debtor if the discounted amount is paid that day. The offer of a discount may initiate an automated negotiation process with the debtor.

A system is provided for augmenting a three-dimensional (3D) model of a heart to indicate the tissue state. The system accesses a 3D model of a heart, accesses two-dimensional (2D) images of tissue state slices of the heart, and accesses source location information of an arrhythmia. The system augments the 3D model with an indication of a source location based on the source location information. For each of a plurality of the tissue state slices of the heart, the system augments a 3D model slice of the 3D model that corresponds to that tissue state slice with an indication of the tissue state of the heart represented by the tissue state information of that tissue state slice. The system then displays a representation of the 3D model that indicates the source location of the arrhythmia and the tissue state of the heart.

The present invention relates to a method and system that automatically finds, segments and measures lesions in medical images following the Response Evaluation Criteria In Solid Tumours (RECIST) protocol. More particularly, the present invention produces an augmented version of an input computed tomography (CT) scan with an added image mask for the segmentations, 3D volumetric masks and models, measurements in 2D and 3D and statistical change analyses across scans taken at different time points. According to a first aspect, there is provided a method for determining volumetric properties of one or more lesions in medical images comprising the following steps: receiving image data; determining one or more locations of one or more lesions in the image data; creating an image segmentation (i.e. mask or contour) comprising the determined one or more locations of the one or more lesions in the image data and using the image segmentation to determine a volumetric property of the lesion.

The present invention relates to a deep learning-based multiple skin lesion detection system, a multiple lesion detection method, and a computer-readable recording medium that has a program for implementing same recorded thereon. The system according to the present invention enables accurate classification and detection of various skin lesions having similar characteristics, on the basis of a context-dependent decision-making structure in which the local spatial correlation between various skin lesions in skin is considered.

Methods and systems are provided for automatically determining a phase shift and noise insensitive similarity metric for electrocardiogram (ECG) beats in a Holter monitor recording. In one embodiment, a deep neural network may be trained to map an ECG beat to a phase shift insensitive and noise insensitive feature space embedding using a training data triad, wherein the training data triad may be produced by a method comprising: selecting a first beat and a second beat recorded via one or more Holter monitors, determining a dynamic time warping (DTW) distance between the first beat and the second beat, setting a similarity label for the first beat and the second beat based on the DTW distance, and storing the first beat, the second beat, and the similarity label, in a location of non-transitory memory as an ECG training data triad.

The present disclosure provides an operating method of a dopamine transporter check system, and the operation method includes steps as follows. A scan image of a subject's brain is obtained from a scan machine, and the scan image is a three-dimensional image. The scan image is aligned to a standard brain space to obtain a standardized scan image. Intensity normalization is performed on the standardized scan image. The standardized scan image after the intensity normalization is converted into a two-dimensional image. A plurality of image data are got from at least one region of interest in the two-dimensional image, and the at least one region of interest includes a left caudate, a left putamen, a right caudate and a right putamen. A dopamine neuron loss degree measurement and evaluation model based on the image data is established through a transfer learning.

A downloadable navigator for a mobile ultrasound unit having an ultrasound probe, implemented on a portable computing device. The navigator includes a trained orientation neural network to receive a non-canonical image of a body part from the mobile ultrasound unit and to generate a transformation associated with the non-canonical image, the transformation transforming from a position and rotation associated with a canonical image to a position and rotation associated with the non-canonical image; and a result converter to convert the transformation into orientation instructions for a user of the probe and to provide and display the orientation instructions to the user to change the position and rotation of the probe.

In a method and apparatus for swallowing impairment detection, a candidate executes one or more swallowing events, and dual axis accelerometry data is acquired representative thereof. Upon feature extraction and classification, vibrational data acquired in respect of each swallowing event is classified as indicative of one of normal or possibly impaired swallowing.