Described herein are systems with interleaved light sources and methods of their use. In some embodiments, a system includes a plurality of light sources, each of which has a bright phase and a dark phase, the system being arranged and constructed so that, for a first light source and a second light source of the plurality, the bright phase of the first light source occurs during the dark phase of a second light source. The example method may further include providing light from the second light source during a dark phase of the first light source. A first and/or second light source may be a swept source or a broadband source. A first and/or second light source may be a laser.

Fluorescence videostroboscopy imaging is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

A laser source (101) comprises: (i) a first beam generating configuration (111, 112, 113) adapted to generate a pulsed primary ablating laser beam (162) with pulses having a first emission spectrum and a first temporal pulse width to ablate one type of tissue, (ii) a second beam generating configuration (121, 122, 123) adapted to generate a pulsed secondary ablating laser beam (163) with pulses having a second emission spectrum different from the first emission spectrum and a second temporal pulse width to ablate another type of tissue different than the one type of tissue ablated by the primary laser beam (162), (iii) a third beam generating configuration (121, 122, 123, 126) adapted to generate a pulsed analysis laser beam (161) with at least one pulse having a third emission spectrum and a third temporal pulse width shorter than the first temporal pulse width and shorter than the second temporal pulse width, and (iv) a beam directing optics (125) with beam aligning elements adapted to align the primary ablating laser beam, the secondary ablating laser beam (163) and the analysis laser beam (161) such that the laser source (101) propagates the laser beams (160) along a same propagation path.

A device and associated method for treatment of tissue in a joint of a mammal includes an energy source and an energy-delivery implement coupled to the energy source. The energy-delivery implement has a distal portion configured to be inserted into the joint, the distal portion having at least one energy-emitting portion. A control module causes the energy source to produce energy in a pre-defined treatment sequence, the sequence comprising at least two pulses of energy separated by an interval. The energy-delivery implement is configured to emit the energy at the distal portion, to create a zone of thermal stress within target tissue, without causing substantial coagulation of the target tissue, wherein the size of the thermal stress zone is substantially less than the size of the target tissue being treated. A biologic can be injected or otherwise delivered into the joint before, during, or after delivery of the energy.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Laser mapping imaging and videostroboscopy is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises a laser mapping pattern.

A method for treating pain using laser therapy is provided. In continuous wave mode, the method comprises a laser receiving a power setting and administering treatments of 810 nm, 910 nm, 1064 nm wavelengths, each of 50 us duration, and each followed by a 5 microsecond pause. When the laser is alternatively configured in pulse mode, the laser repeats, after a computer-generated pause, the first, second, and third laser treatments. In pulse mode, an emission frequency (Hz) determines a beat or rhythm of a pulse mode being used a frequency of pulse is set via provider selection entered via touch screen on the laser with preset times.

A system for the treatment of targets under the skin of a patient comprising: a laser device for emitting a first series of laser pulses towards an area of the skin of a patient, where a target which must be reached by said laser pulses is located under said skin; a cooling system of said area of the skin by means of a cooling fluid; a first measurement sensor of a first temperature of said area of skin; a second measurement sensor of the temperature of said cooling fluid; said computer which receives the signals from said first and second temperature measurement sensor; said computer controls said laser device that emits a first series of laser pulses having predetermined power, duration and spacing; said temperature measurement sensor measures the temperature of said area of skin, following said first series of laser pulses; said computer calculates the predicted temperature reached of said area of the skin following the emission of a second series of pulses having said predetermined power, duration and spacing.

A method for providing localized heating of the dermal layers of skin of a patient, using energy in the form of a group of pulses having defined parameters in a controlled manner. This method preferably uses an optical delivery system to deliver pulsed energy to a specific spot of skin so that targeted layers of the affected skin are heated to a desired temperature range. The temperature range is optimally selected to maximize treatment efficacy while minimizing pain to the patient. Example applications include reducing wrinkles, acne, hair, scar tissue, warts, and promoting wound healing. In this method, the temperature of the selected locus rises quickly to the desired temperature range, then is maintained within a controlled range with a relatively flat temperature profile. The method maintains the temperature by controlling one or more of a pulse energy intensity, pulse width, and pulse frequency or time delay between pulses.