An electrosurgical system includes an electrosurgical generator and an electrosurgical instrument coupleable to the electrosurgical generator. The electrosurgical generator includes a controller, a power supply coupled to the controller, and a power converter coupled to the power supply. The controller is configured to cause the power converter to generate a pulsed electric field configured to electroporate tissue and RF current configured to seal tissue. The electrosurgical instrument includes a pair of opposing jaw members configured to grasp tissue. Each of the pair of opposing jaw members includes an electrically conductive tissue-contacting surface configured to electroporate tissue disposed in proximity to the electrically conductive tissue-contacting surfaces via the pulsed electric field and deliver the RF current to the electroporated tissue to seal the electroporated tissue.

Disclosed is a pulsed laser system for dermatological treatment, including a light source suitable for emitting a light pulse beam and an optical amplifier system suitable for generating a laser pulse beam at a first repetition frequency. The duration of a laser pulse is between 100 femtoseconds and 100 picoseconds, the first repetition frequency is between 1 kHz and 10 GHz, each laser pulse having a quantity of energy less than or equal to 1 microjoule, and the pulsed laser system also includes a unit for temporally modulating the laser pulse beam and/or a unit for spatially modulating the laser pulse beam, the temporal and/or spatial modulation means being suitable for reducing the density of energy deposited on a surface to be treated and for generating a density of energy of between 0.0001 J/cm.sup.2 and 0.01 J/cm.sup.2.

A photo-thermal targeted treatment system for damaging a target embedded in a medium includes a controller and a photo-thermal treatment unit including a light source. The controller is configured for administering a treatment protocol using the light source at a preset power setting and a preset pulse timing setting. Also, a method for automatically initiating a treatment protocol using a photo-thermal targeted treatment system includes administering a cooling mechanism at a treatment location, monitoring a skin surface temperature at the treatment location and, when the skin surface temperature reaches a preset threshold, automatically initiating the photo-thermal treatment protocol. Further, a method for automatically terminating a treatment protocol using includes, during administration of the treatment protocol at a treatment area, monitoring a skin surface temperature at the treatment location, and when the skin surface temperature reaches a preset threshold, automatically terminating the treatment protocol.

A method for treating a wart on skin of a patient includes guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart for a length of time effective to give rise to an at least partial amelioration of the wart.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2), which is configured to emit an electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source can be varied, wherein the electronic control unit is operatively connected to the illumination source and configured to control operation of the illumination source according to an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source during the illumination session in a plurality of different modes, the modes comprising: a) a first mode, wherein, in the first mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is increased continuously or quasi-continuously from a base intensity B to a target intensity T within a first mode time interval, b) a second mode, wherein, in the second mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is constant or substantially constant for a second mode time interval, and c) a third mode, wherein, in the third mode, the electronic control unit controls operation of the illumination source such that the illumination source is operated such that darker phases and illumination phases alternate for a third mode time interval, wherein the intensity of the electromagnetic radiation emitted by the illumination source is lower in the darker phases than in the illumination phases, or wherein, in the darker phases the illumination source does not emit electromagnetic radiation whereas the illumination source emits electromagnetic radiation in the illumination phases. Furthermore, a computer program product and a kit for treating a disease are provided and a method for operating an illumination source and a method for treating a skin disease.

An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2), which is configured to emit an electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source can be varied, wherein the electronic control unit is operatively connected to the illumination source and configured to control operation of the illumination source according to an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source during the illumination session in a plurality of different modes, the modes comprising: a) a first mode, wherein, in the first mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is increased continuously or quasi-continuously from a base intensity B to a target intensity T within a first mode time interval, b) a second mode, wherein, in the second mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is constant or substantially constant for a second mode time interval, and c) a third mode, wherein, in the third mode, the electronic control unit controls operation of the illumination source such that the illumination source is operated such that darker phases and illumination phases alternate for a third mode time interval, wherein the intensity of the electromagnetic radiation emitted by the illumination source is lower in the darker phases than in the illumination phases, or wherein, in the darker phases the illumination source does not emit electromagnetic radiation whereas the illumination source emits electromagnetic radiation in the illumination phases. Furthermore, a computer program product and a kit for treating a disease are provided and a method for operating an illumination source and a method for treating a skin disease.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Various aspects of the present invention are directed towards apparatuses, systems, and methods that may include a tissue ablation system. The tissue ablation system may include a plurality of ablation devices, each ablation device being configured to provide ablation energy, at least one ablation generator configured to provide ablation power to at least one of the plurality of ablation devices, and a controller configured to cause each of the plurality of ablation devices to selectively receive ablation power and configured to cycle through activation of a plurality of ablation states.

Described here are devices and methods for forming shock waves. The devices may comprise an axially extending elongate member. A first electrode pair may comprise a first electrode and a second electrode. The first electrode pair may be provided on the elongate member and positioned within a conductive fluid. A controller may be coupled to the first electrode pair. The controller may be configured to deliver a series of individual pulses to the first electrode pair, where each pulse creates a shock wave. The controller may cause current to flow through the electrode pair in a first direction for some of the pulses in the series and in a second direction opposite the first direction for the remaining pulses in the series.