This invention is an intrasacular aneurysm occlusion device with nested structures, including an inner embolic structure (e.g. inner mesh, net, braid, and/or stent) which is nested inside an outer embolic structure (e.g. outer mesh, net, braid, and/or stent). The inner embolic structure can have an ellipsoidal, toroidal, inverted jug, or inverted bottle shape. The outer embolic structure can have a spherical shape. The device can also have an opening and valve through which embolic material is inserted into the aneurysm sac.

A device for applying a tissue healing agent includes an insertion member extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, a delivery element including a first surface and a second surface opposing one another, the delivery element movable between a closed configuration, in which the delivery element is compressed to be received within the channel, and an open configuration, in which the delivery element is substantially planar, and a first tissue healing agent formed in a sheet configuration and disposed on the first surface of the delivery element.

A clotting agent delivery system comprises a frame, a passageway extending along the frame, a discharge opening connected to the passageway, a clotting agent reservoir fluidly connected to the passageway to hold a clotting agent substance, a valve in the passageway to control flow of the substance through the passageway, and an actuator to allow propellent to flow into the passageway, wherein the valve and clotting agent reservoir cooperate to provide clotting agent substance to the discharge opening at constant pressure using the propellant. A method for delivering a clotting agent comprises inserting a delivery catheter into an anatomic area, coupling a clotting agent delivery system to the delivery catheter, the clotting agent delivery system having a reservoir of a clotting agent, operating a valve to release propellant for propelling the clotting agent, and conveying the propellant and the clotting agent to the delivery catheter at a constant pressure.

A guide wire is disclosed, which is capable of reducing an unintended deviation in a guide wire position while preventing an occurrence of discomfort with respect to usability. The guide wire has a flexible core wire, and has a distal core portion, a main body portion, and a rigidity changing portion that gradually decreases in rigidity from the main body portion toward the distal core portion. The rigidity changing portion includes a first tapered portion continuous with a distal end of the main body portion, a second tapered portion continuous with a distal end of the first tapered portion, and a third tapered portion continuous with a proximal end of the distal core portion. A boundary portion between the first tapered portion and the second tapered portion is located in a range of 300 to 400 mm from a foremost distal end of the distal core portion.

Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity via an elongated shaft and transforming a shape of the occlusive member within the cavity. The method may include introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall. In some embodiments, the elongated shaft is detachably coupled to a distal portion of the occlusive member.

A method for evaluating image data of a patient showing a target region to be treated with an embolizing agent includes providing a three-dimensional time-resolved image data set of a vascular system portion of the patient. A structural parameter that describes a geometry of at least the vascular system portion and/or a basic information item including dynamic parameters that describe hemodynamics in the vascular system portion is established from the image data set by an analysis algorithm. An embolization information item describing a plurality of embolizing agents that are to be used is provided. An actuation information item describing a suitable composition of the plurality of embolizing agents, for an intervention facility used for carrying out the treatment is established by an establishing algorithm that uses the basic information item and the embolization information item, and the actuation information item is provided to the intervention facility.

Devices and methods are described for a minimally invasive procedure offering immediate relief of brain compression and prevention of subdural hematoma re-accumulation. For example, this disclosure describes devices and methods for embolization of bleeding branch vessels of the middle meningeal artery and subdural hematoma drainage in a single endovascular intervention using multimodal catheter-based technology.

Various devices, systems, and methods that can be used in the treatment of obesity and related illnesses are disclosed. In some instances, the cecum of an obese patient is distended to a pathophysiological size for a therapeutically effective period. The distention may be achieved by introduction of an object that is of foreign origin relative to the body of the patient into the cecum of the patient. In some instances, the distention is achieved by a medical device that transitions from an undeployed state, in which the medical device is introduced into the cecum of the patient, to an expanded state in which the medical device distends the cecum by an amount sufficient to trigger a colo-gastric brake in the patient.

Devices and methods are described for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body. The device may have a thromboresistant cover at a proximal end. The frame may have recapture struts inclining radially outwardly from a central hub. The frame may have axially extending side wall struts, with adjacent pairs of side wall struts joined at one or more apexes. Anchors extend from the frame and into the foam to engage tissue.

Intrasaccular devices and methods of implanting the devices in an aneurysm are described. The device includes an expandable body comprising a plurality of elongate filamentary elements each having a first and a second end. Each of the plurality of elongate filamentary elements extends from a first end of the device to a second end of the device and back to the first end of the device. The first and second ends of each of the plurality of elongate members are coupled at the first end of the device in a hub. The device may further include a defect spanning structure made of a mesh. The defect spanning structure may be located around a proximal portion of the expandable body, and may be disposed exteriorly to an outer surface of the expandable body