An anti-contamination laser surgery device with a built-in optical element, including an inner cylinder, an outer cylinder, a first unit configured to enable the inner cylinder and the outer cylinder to be telescopic, a lens moving unit, a two-dimensional laser scanning unit, a real-time monitoring unit, and a second unit configured to perform unidirectional laminar flow ventilation. A head end of the inner cylinder and a tail end of the outer cylinder are matched and connected by the first unit. The two-dimensional laser scanning unit and the real-time monitoring unit are arranged at the head end of the outer cylinder, and the lens moving unit is arranged in the inner cylinder and close to the head end of the inner cylinder. The second unit is arranged close to a tail end of the inner cylinder.

There is provided a passive Q-switch pulse laser device including a laser medium, and a saturable absorber. The laser medium is disposed between a pair of reflection means included in an optical resonator. The laser medium is excited by specific excitation light to emit emission light. The saturable absorber is disposed on an optical axis of the optical resonator and on a downstream side of the laser medium between the pair of reflection means. The saturable absorber has a transmittance increased by absorption of the emission light. At least one of the pair of reflection means is a polarizing element. The polarizing element has different reflectances with respect to the respective pieces of emission light in polarization directions orthogonal to each other.

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

In certain embodiments, a system for controlling a position of a focal point of a laser beam comprises a beam expander, a scanner, an objective lens, and a computer. The beam expander controls the focal point of the laser beam and includes a mirror and expander optical devices. The mirror has a surface curvature that can be adjusted to control a z-position of the focal point. The expander optical devices direct the laser beam towards the mirror and receive the laser beam reflected from the mirror. The scanner receives the laser beam from the beam expander and manipulates the laser beam to control an xy-position of the focal point. The objective lens receives the laser beam from the scanner and directs the beam towards the target. The computer receives a depth instruction, and sets actuation parameters to control the surface curvature of the mirror according to the depth instruction.

A laser system includes a laser source generating a laser beam having ultra-short pulses; a laser delivery assembly optically receiving the laser beam and comprising: a beam splitter configured to split the laser beam between a first beam delivery path and a second beam delivery path; and at least one focusing lens optically coupled to the beam splitter and configured to focus the laser beam from each of the first beam delivery path and the second beam delivery path to a focal point on a predefined plane; wherein the first beam delivery path intersects the predefined plane at a first angle, the second beam delivery path intersects the predefined plane at a second angle, and a first pulse from the first beam delivery path and a second pulse from the second beam delivery path are coincident at the focal point.

A tissue-treating portion of a surgical instrument includes a body defining a cavity and a light-energy transmissible sphere captured within the cavity such that a portion of the light-energy transmissible sphere protrudes from the body. The light-energy transmissible sphere is capable of unlimited rotation in all directions relative to the body. The light-energy transmission cable extends through the body to a position spaced-apart from the light-energy transmissible sphere. The light-energy transmission cable is configured to transmit light energy to the light-energy transmissible sphere. The light-energy transmissible sphere, in turn, is configured focus the light energy towards tissue to treat tissue.

An ophthalmic surgical laser system and method for forming a lenticule in a subject's eye using “fast-scan-slow-sweep” scanning scheme. A high frequency scanner forms a fast scan line, which is placed by the XY and Z scanners at a location tangential to a parallel of latitude of the surface of the lenticule. The XY and Z scanners then move the scan line in a slow sweep trajectory along a meridian of longitude of the surface of the lenticule in one sweep. Multiple sweeps are performed along different meridians to form the entire lenticule surface, and a prism is used to change the orientation of the scan line of the high frequency scanner between successive sweeps. In each sweep, the sweeping speed along the meridian is variable, being the slowest at the edge of the lenticule and the fastest near the apex.

Provided herein are methods for inducing an anti-tumor immune response and/or treating cancer comprising treating tumor tissue of the subject with energy to induce fractional tissue damage in combination with one or more checkpoint molecule modulating agents.

A laser system includes a first laser cavity to output a laser light along a first path, a first mirror to receive the laser light from the first laser cavity, and redirect the laser light along a second path that is different than the first path, a second mirror to receive the laser light from the first mirror, and redirect the laser light along a third path that is different than the first path and the second path, a beam splitter located at a first position on the third path, a beam combiner located at a second position on the third path; and a coupling lens assembly, the coupling lens assembly including a lens located at a third position on the third path, wherein the coupling lens assembly moves the lens in x-, y-, and x-directions.

The present disclosure provides a method and system for estimating the temperature of a working environment. Treatments that use laser and optical fiber technology may cause an undesirable increase in the temperature of a working environment. To that end, a laser source to generate light beams sensitive to a change in temperature can be generated and the temperature determined based on a distance between a distal end of the optical fiber and a target and the generated temperature sensitive light beam.