The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

The device comprises an outer conductor (7) and an inner conductor (9) arranged approximately coaxial with each other. The outer conductor surrounds the inner conductor. The outer conductor (7) and the inner conductor (9) are arranged and configured to generate an electromagnetic field with lines of force extending from a front surface (9A) of the inner conductor (9) to a front surface (7C) of the outer conductor (7). The device further comprises an energy delivery window (13) arranged in front of the outer conductor and the inner conductor.

The device comprises an outer conductor (7) and an inner conductor (9) arranged approximately coaxial with each other. The outer conductor surrounds the inner conductor. The outer conductor (7) and the inner conductor (9) are arranged and configured to generate an electromagnetic field with lines of force extending from a front surface (9A) of the inner conductor (9) to a front surface (7C) of the outer conductor (7). The device further comprises an energy delivery window (13) arranged in front of the outer conductor and the inner conductor.

A catheter system (100) for treating a treatment site (106) includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates pulses of energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive the energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104). The balloon integrity protection system (142) is configured to inhibit temperature-induced rupture of the balloon (104) due to the plasma formed in the balloon fluid (132) within the balloon interior (146) during use of the catheter system (100).

Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

A dilator used in performing a transseptal puncture; it has a hub with an opening at a proximal end; a shaft, connected to a distal end of the hub, comprising a lumen miming along a length of the shaft defining an inner wall within the shaft; an optical fiber for insertion into the lumen of the shaft, the optical fiber comprising a proximal end portion for sealing the opening of the hub, the optical fiber having a length for running along a length of the lumen; wherein the optical fiber is configured to, in a simultaneous or alternating fashion: propagate a laser beam with an ultrafast pulse duration that is generated by an ultrafast laser; and propagate light for obtaining visualization information from the light interacting with neighboring surfaces in the heart using optical coherence tomography.

A dilator used in performing a transseptal puncture; it has a hub with an opening at a proximal end; a shaft, connected to a distal end of the hub, comprising a lumen miming along a length of the shaft defining an inner wall within the shaft; an optical fiber for insertion into the lumen of the shaft, the optical fiber comprising a proximal end portion for sealing the opening of the hub, the optical fiber having a length for running along a length of the lumen; wherein the optical fiber is configured to, in a simultaneous or alternating fashion: propagate a laser beam with an ultrafast pulse duration that is generated by an ultrafast laser; and propagate light for obtaining visualization information from the light interacting with neighboring surfaces in the heart using optical coherence tomography.

An apparatus and methods for tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, the catheter shaft defining lumens including an inflation lumen and a light fiber lumen, a coated balloon positioned on a translucent distal segment of the catheter shaft proximal to the distal tip in fluid communication with the inflation lumen, the coated distal balloon comprising a translucent material and a coated material on an outer surface of the coated balloon, and a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the translucent distal segment.

Disclosed herein are methods to restore myocardial conduction via the injection of conductive nanoparticles into the myocardium via an endovascular injection catheter.