According to an embodiment of the present disclosure, there is provided a laser spectroscopy-based independent device, including: a spectrometer configured to measure a spectrum of generated light which is generated by a laser projected onto a sample; and a disease analysis module configured to determine whether there is lesion tissue by applying a lesion tissue detection learning model to a result of non-discrete spectrum measurement, which is measured by the spectrometer, wherein the spectrometer is configured to measure spectra of all generated light that is generated from a time when the laser is projected onto the sample.

A spine measurement system comprising a camera, an encoded collar, and a remote station. A rod is shaped having one or more bends to modify a curvature of a spine. The encoded collar is coupled to the rod. The encoded collar includes a plurality of markings where each marking represents a rod position. The rod and encoded collar are in a field of view of the camera. The camera takes a number of images as the rod rotates at least 360 degrees. The remote station measures the 2D images to produce quantitative measurements that yield a 3D model of the rod shape. The remote station can use the 3D rod shape to determine metrics that relate to how the rod shapes the spine. For example, a Cobb angle can be calculated from the rod shape to determine if the rod yields the desired spine outcome.

Kits, diagnostic systems and methods are provided, which measure the distribution of colors of skin features by comparison to calibrated colors which are co-imaged with the skin feature. The colors on the calibration template (calibrator) are selected to represent the expected range of feature colors under various illumination and capturing conditions. The calibrator may also comprise features with different forms and size for calibrating geometric parameters of the skin features in the captured images. Measurements may be enhanced by monitoring over time changes in the distribution of colors, by measuring two and three dimensional geometrical parameters of the skin feature and by associating the data with medical diagnostic parameters. Thus, simple means for skin diagnosis and monitoring are provided which simplify and improve current dermatologic diagnostic procedures.

A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45 relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45 relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level. The method also comprises using the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. Apparatuses that use these methods are also described.

Provided is a photoacoustic apparatus capable of recognizing variation in reception characteristic among a plurality of receiving elements that detect an acoustic wave in the photoacoustic apparatus, with a simple configuration unique to the photoacoustic apparatus. A photoacoustic apparatus includes a detecting unit including a plurality of receiving elements configured to detect an acoustic wave that is generated when an analyte is irradiated with light; a signal processing unit configured to acquire information about the inside of the analyte from a detected signal acquired from the detecting unit; an optical absorber configured to absorb the irradiation light; and a reception characteristic calculation unit configured to calculate reception characteristic information of the plurality of receiving elements on the basis of detected signals when the plurality of receiving elements receive an acoustic wave that is generated from the optical absorber.

At an imaging site an imaging device (14) generates an image of a subject (4) and an imaging light markers generation device (6) generates light markers at locations on a surface of the subject before an interventional procedure is performed. At an interventional site an interventional light markers generation device (17) generates light markers at the locations on the surface of the subject (4) and a localization device (25, 27) determines the position of a catheter during the interventional procedure. A position determination unit (29) then determines the position of the catheter within the pre-interventional image based on the position of the catheter determined by the localization device and provided spatial relations between the devices used for generating the image and the light markers and for localizing the catheter. This allows showing the position of the catheter within the pre-interventional image without necessarily using x-rays.

A subjective optometry apparatus includes subjective measurement unit for subjectively measuring an optical characteristic of a subject eye, the subjective measurement unit including a calibration optical system that is disposed in an optical path of a light projecting optical system projecting a visual target luminous flux toward the subject eye and changes an optical characteristic of the visual target luminous flux. The subjective optometry apparatus includes objective measurement unit for objectively measuring the optical characteristic of the subject eye, the objective measurement unit including a measurement optical system that emits measurement light to a fundus of the subject eye and receives reflected light of the measurement light. The subjective optometry apparatus includes controller for objectively measuring the optical characteristic of the subject eye by the objective measurement unit while the optical characteristic of the subject eye is subjectively measured by the subjective measurement unit.

A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into a phase delay detection system that provides an output thereof a digital measure of the phase delay of the received optical signal.

The present invention relates to a method and a device for enabling to analyze a property of a vital sign detector (20). The proposed method comprises the steps of providing a virtual phantom (14) of a living being, rendering an artificial vital sign on the displayed virtual phantom (14), and outputting the virtual phantom (14) with the rendered artificial vital sign to the vital sign detector (20).