The invention relates to an artificial periosteum comprising a functionalized collagen-containing membrane and a drug-carrier mixture, wherein the drug-carrier mixture comprises at least one therapeutic agent and a calcium-containing carrier mixture. The invention also relates to use of the artificial periosteum for repairing bone.

A meniscus replacement device for replacing damaged soft tissue at a host knee includes a first component comprising a first tissue-interface surface shaped to free-floatingly interface with tissue structure of one of a femur and a tibia in a knee joint having a damaged soft tissue, and comprises a second component comprising a second tissue-interface surface shaped to free-floatingly interface with a second tissue structure of the other of the femur and the tibia in the knee joint. The second component may include a containment cavity receiving at least a portion of the first component. In another form, the free floating soft joint tissue replacement component and the base component are fixed together. In some aspects, the second tissue-interface surface is shaped to fit contours of a natural tibia plateau. In some aspects, the first tissue-interface surface is shaped to fit contours of a femoral surface.

The methods disclosed herein of generating three-dimensional lattice structures and reducing stress shielding have applications including use in medical implants. One method of generating a three-dimensional lattice structure can be used to generate a structure lattice and/or a lattice scaffold to support bone or tissue growth. One method of reducing stress shielding includes generating a structural lattice to provide sole mechanical spacing across an area for desired bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. Some methods are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

The present invention relates to a monolithic multi-layered material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a monolithic medical material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention.

The present disclosures describe devices and methods to repair cartilage defects using arthroscopic surgical methods. The disclosed devices include a cannula assembly including a cannula body, a dam seal sub-assembly disposed proximally from the cannula body, and an obturator inserted coaxially through both the cannula body and the dam seal sub-assembly; an articulated arthroscopic cutting tool; a ring curette; a square curette; a rake curette; a matrix shuttle delivery device for delivering a cell-seeded support matrix including chondrocytes; and an applicator tool.

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

The three-dimensional lattice structures disclosed herein have applications including use in medical implants. Some examples of the lattice structure are structural in that they can be used to provide structural support or mechanical spacing. In some examples, the lattice can be configured as a scaffold to support bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. The lattice structures are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

An implant for repairing an articular cartilage defect site including an implant fixation portion with an upper segment and at least one bone interfacing segment and a top articulating portion with an articulating surface and an engagement surface. The upper segment includes a supporting plate with a first locking mechanism segment. The engagement surface includes a second locking mechanism segment. The first locking mechanism segment with at least two channels is structured to couple to the second locking mechanism segment with at least two protrusions. The at least one bone interfacing segment structured for insertion into the articular cartilage defect site. An implant including an implant fixation portion, a top articulating portion, and a locking mechanism with a first locking segment coupled to the upper segment and a second locking segment coupled to the at least one engagement surface and structured to couple to the first locking segment.

Implants, systems, instruments, methods, and kits for metatarsophalangeal joint arthroplasty may include metatarsal arthroplasty implants, repositioning guides, broach tools, inserter tools, and sterilizable packaging configured to facilitate metatarsal arthroplasty surgical procedures. The metatarsal arthroplasty implants may generally include an articular member having a convex articular surface, a concave bone-facing surface opposite the convex articular surface, and at least one side surface intermediate the convex articular surface and the concave bone-facing surface, as well as a central shaft sized for insertion into a metatarsal bone having a central shaft longitudinal axis, a central shaft proximal end coupled to the concave bone-facing surface of the articular member, and a central shaft distal end extending away from the concave bone-facing surface of the articular member along the central shaft longitudinal axis.