Systems and methods are described for correcting sagittal imbalance in a spine including instruments for performing the controlled release of the anterior longitudinal ligament through a lateral access corridor and hyper-lordotic lateral implants.

A method for treating a spine is provided. The method includes the steps of: disposing an interbody implant adjacent a first vertebral surface and a second vertebral surface of an intervertebral disc space, the interbody implant engaging the vertebral surfaces at a selected angular orientation; connecting the interbody implant with at least one of the vertebral surfaces via at least one fastener that is engaged with the interbody implant and fixed with the vertebral surface such that the at least one fastener is movable to a plurality of axial orientations relative to the interbody implant; and manipulating the vertebral surfaces such that the at least one fastener is fixed relative to the interbody implant. Spinal implants, surgical instruments and systems are disclosed.

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

A system for stabilizing a cervical spine segment includes a pair of uncinate joint stabilizers for stabilizing a respective pair of uncinate joints. Each uncinate joint stabilizer is elongated along a lengthwise dimension and is configured for placement in the respective uncinate joint with the lengthwise dimension substantially oriented along an anterior-to-posterior direction of the cervical spine segment. Each uncinate joint stabilizer has height configured to define spacing of the respective uncinate joint. Each uncinate joint stabilizer includes a generally cylindrical portion with cylinder axis in the lengthwise dimension. The generally cylindrical portion has threads for threading the uncinate joint stabilizer into the respective uncinate joint along the anterior-to-posterior direction. The threads are interrupted by one or more fenestrations configured to accommodate bone graft material, bone growth, and/or tissue displaced from the respective uncinate joint by the uncinate joint stabilizer.

An osteotomy implant includes a first surface extending generally in a first plane and a second surface extending generally in a second plane, oblique to the first plane. The first surface has a perimeter having a first linear edge, a first curve edge connected to the first linear edge, a second linear edge connected to the first curved edge, and a second curved edge connected to the second liner edge.

Systems and methods are described for correcting sagittal imbalance in a spine including instruments for performing the controlled release of the anterior longitudinal ligament through a lateral access corridor and hyper-lordotic lateral implants.

The present invention is directed to a hinge joint implant (40) configured to fit in a joint cavity and which can comprise, when in situ, an at least hemi-spherocylindrical configuration, and further a hinge joint implant configured to fit in a joint cavity wherein the implant can extend around the sides of a joint component which may be a bone and/or cartilage. The invention further provides the use of a hinge joint implant according for treating arthritis, and/or torn cartilage, and a method for manufacturing a hinge joint implant from one or more pieces.

A tibial implant includes one or more stiffness-modifying features to reduce the stiffness of one or more sections of the tibial implant. The stiffness-modifying features may include slots, recesses, or passageways defined in various locations of the tibial implant to selectively reduce the stiffness of a tibial insert and/or tibial base of the tibial implant.

A vertebral body system and method having a polyaxial fastener receiving member, adjustable width plates and a pedicle screw having a pedicle threaded portion and a threaded portion for fastening to the vertebral body.

Placement apparatus and methods of use for impanation of spacers within an inter-vertebral disc space. In one embodiment, the load-bearing superstructure of the implant is subdivided and the bone forming material is positioned within an internal space of the placement instrument but external to the load bearing elements themselves. At least a portion of the bone graft material is freely contained within the disc space. A method of using the device is also described. In one embodiment, the placement device is used to place the implantable spacers at opposing ends of the disc space using a directly lateral surgical approach.