A biomedical implant (16, 18) is formed from magnesium (Mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. The biomedical implant (16, 18) may be post treated to control the mechanical properties and/or corrosion rate thereof said Mg single crystal (10) without changing the chemical composition thereof. A method of making a Mg single crystal (10) for biomedical applications includes filling a single crucible (12) with more than one chamber with polycrystalline Mg, melting at least a portion of said polycrystalline Mg, and forming more than one Mg single crystal (10) using directional solidification.

A customized artificial temporomandibular joint unit according to an embodiment of the present disclosure includes a first plate provided along a lower line of a lower jawbone forming a temporomandibular joint and having an insertion groove that is outwardly open, a second plate provided at a temporal bone forming the temporomandibular joint together with the lower jawbone, and a main prothesis detachably combined to the first plate without a separate fastening device by being forcibly fit into the insertion groove while approaching the first plate, and arranged in a customized manner at a facing surface location facing the second plate.

The disclosed embodiments relate to a temporomandibular joint prosthesis including a joint portion, a fixation portion, and at least one flexible unit. The joint portion is configured to be as a temporomandibular joint and movably connected to cranial skeleton. The fixation portion is configured to be fixed on mandible. The flexible unit is located between and connected to the joint portion and the fixation portion. The fixation portion is movable with respect to the joint portion via the flexible unit.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

The invention relates to a biocompatible molded part for supporting new bone formation, in particular the reformation of a jaw bone or a jaw bone portion in a mammal, preferably a human, wherein the molded part is suitable to be placed on the jaw bone and is designed as a solid body. The invention also relates to a composition for producing a biocompatible molded part, a method for producing a biocompatible molded part, a use of a biocompatible molded part and a kit comprising a plurality of molded parts.

The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

An implantable mandibular joint prosthesis includes a first implant part that has an artificial condyle and that can be attached to a lower jawbone, a second implant part that has a joint surface that can be attached to a cranium and that forms an abutment for the artificial condyle. The second implant part comprises includes a first component, which is formed from a metal material and can be attached to the cranium, and a second component, which is formed from a plastics material and forms the joint surface. The first component has a first connection surface and the second component has a second connection surface wherein the first and second connection surfaces are mutually engagingly joined together.

The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

Systems, methods, and apparatuses for relieving upper airway obstructive breathing in a patient are disclosed. In some implementations, the apparatus comprises first and second pivot devices anchored to a mastoid bone and a mandible bone, respectively; an implant positioned between the first and second pivot device, the implant comprising a first end coupled to the first pivot device and a second end coupled to the second pivot device; an inactive position, the inactive position enabling a posterior displacement of the second end relative to the first end; an active position, the active position preventing posterior displacement of the second end relative to the first end, and anteriorly positioning the second end relative to the first end; and an activation mechanism enabling transition between the inactive position and the active position, and vice versa.

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.