Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

A method for an eye treatment includes the steps of: providing guide elements made on the specific sites of a subject which comprise (1) a site that intersects a perpendicular line of medial malleolus and an extension line of medial margin on OS metatasale primam 1 and 2, (2) a pupil of a left or right eye, (3) ST 36 point of a left or right leg, and (4) SP point; and controlling a temperature of the guide elements to be a range from 40 to 50±5° C., thereby applying the thermal stimulus to the respective specific sites to increase a blood flow by 60% or more and promote secretion of a growth hormone in the subject.

A method of promoting secretion of a growth hormone includes the step of applying a thermal stimulus to specific sites on a body surface of the subject. The step of applying the thermal stimulus includes the steps of placing two or more guide elements made of two different kinds of metals respectively on at least two different sites of the specific sites, and controlling a temperature of the guide elements to be a range from 40 to 505 C., thereby applying the thermal stimulus to the specific sites according to a thermal stimulus pattern so as to increase a rate of blood flow in the subject by 60% or more by the application of thermal stimulus.

Systems for treating a subject's tissue can include a thermally conductive cup, a tissue-receiving cavity, and a vacuum port. The vacuum port is in fluid communication with the tissue-receiving cavity to provide a vacuum for drawing the submental tissue, or other targeted tissue, into the tissue-receiving cavity. A thermal device can cool and/or heat the conductive cup such that the conductive cup non-invasively controls the temperature of subcutaneous lipid-rich cells in the tissue. A restraint apparatus can hold a the conductive cup in thermal contact with the target region.

A compress for treating and preventing radiation dermatitis, comprising a reservoir layer configured to store and release a mixture of skin-cooling ingredients, wherein the compress is cold before applying to skin exposed to radiation therapy or becomes cold after applying to skin exposed to radiation therapy.

A therapeutic treatment system has a delivery device is adapted to deliver a cooled breathing gas mixture to a patient and an injection device positioned near a distal end of the delivery device. The injection device is coupled to a source of liquid. The treatment system also includes a control system coupled to the delivery device and the injection device. Alternatively, the control system is adapted to control the injection device to release a fluid into the cooled breathing gas mixture to form a frozen mist of fine ice particles in the cooled breathing gas mixture.

Systems for treating a subject's tissue can include a thermally conductive cup, a tissue-receiving cavity, and a vacuum port. The vacuum port is in fluid communication with the tissue-receiving cavity to provide a vacuum for drawing the submental tissue, or other targeted tissue, into the tissue-receiving cavity. A thermal device can cool and/or heat the conductive cup such that the conductive cup non-invasively controls the temperature of subcutaneous lipid-rich cells in the tissue. A restraint apparatus can hold a the conductive cup in thermal contact with the target region.

The systems and methods in accordance with the principles of the invention can promote correction of an aesthetic or functional defect in a target tissue. A method can include non-invasively applying a cooling agent to a surface of a target tissue; and cooling one or more tissue layers of said target tissue to a predetermined therapeutic temperature, wherein applying the cooling agent is performed such that cryoablation of said one or more layers of the target tissue does not occur. The system can include: a controller and a probe having a distal end configured for non-invasive contact with a surface of a target tissue to cool the target tissue based on treatment parameters.

A brassiere incorporating a hot flash mitigation system for cooling the upper torso, chest and neck area of a wearer is disclosed. The brassiere comprises two front panel sections connectively engaged to each other, at least one rear panel section connectively engaged to each of the two front panel sections. The hot flash mitigation system provides a deformable reservoir for containing and dispensing a fluid therefrom. The deformable reservoir is disposed in mating and contacting engagement with the brassiere and has an outlet in cooperative fluid engagement thereto. At least one duct disposed proximate to one of the at least two front panel sections is in fluid engagement with the outlet of the deformable reservoir. At least one nozzle disposed upon an end of the duct distal from the deformable reservoir operatively conveys the fluid from the duct to the upper torso, chest and neck area of the wearer.

A brassiere incorporating a hot flash mitigation system for cooling the upper torso, chest and neck area of a wearer is disclosed. The brassiere incorporating a hot flash mitigation system provides for a brassiere and at least one electronic hot flash mitigation system cooperatively associated thereto. The electronic hot flash mitigation system provides at least one fluid source having a valve in fluid engagement with an outlet thereof, at least one duct disposed proximate to one of the at least two front panel sections and in fluid engagement with the outlet of the fluid source, and at least one nozzle disposed upon an end of the duct distal from the fluid source and in fluid communication with the at least one duct.