A therapeutic method can include receiving an initial astigmatism condition of an eye; receiving a target final astigmatism condition of the eye; generating, based on the initial and target final astigmatism conditions, an eye incision pattern by iterating through a plurality of potential corrective combinations; and cutting the eye based on the eye incision pattern. Each of the potential corrective combinations can be defined by one or more of: an intraocular lens selected from a plurality of intraocular lens options, an access incision selected from a plurality of access incision options, and an arcuate incision selected from a plurality of arcuate incision options.

Systems and methods related to corneal ablation for treatment of one or more high-order optical aberrations are provided. A method includes providing a defect-correcting prescription, determining an ablation profile to impose the prescription on the cornea, and determining a sequence of laser-energy ablations to impose the ablation profile on the cornea. The prescription may include a high-order optical correction. The ablation profile includes a first-segment profile and a second-segment profile. The second-segment profile corresponds to at least one high-order optical correction. The ablation sequence includes applying ablations corresponding to the first-segment profile prior to applying ablations corresponding to the second-segment profile.

A marker device for producing paint marks on an eye is disclosed. The marker device comprises a handling unit and a marker unit coupled to the handling unit for rotation with respect to the handling unit about a rotational axis. The marker unit includes at least two spaced apart marking surfaces and has a rotationally symmetric distribution of weight with respect to the rotational axis. A coupling between the handling unit and the marker unit permits the marker unit to rotate, due to gravity, relative to the handling unit into an equilibrium position.

A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.

A laser conical photoablation system in accordance with the present invention comprises a corneal measurement unit configured to measure a cornea and obtain state data of the cornea, a laser control unit configured to control an output intensity and range, an amount, and time of a laser according to a photoablation position and a photoablation shape of the cornea based on a corneal photoablation plan generated based on the state data of the cornea, and a laser module configured to irradiate the cornea with a laser according to a control signal applied by the laser control unit, wherein the state data of the cornea includes a conical surface elevation map, and the laser corneal photoablation system treats dry eye disease by performing corneal photoablation on a surface elevation deviation portion of the cornea.

An ophthalmological device comprises a laser source, an application head having focusing optics and a patient interface, a scanner system and circuit. The circuit is configured to control the scanner system to incise an incision surface, which is symmetrical with respect to the central axis of the patient interface, in the eye tissue, a pulsed laser beam being steered onto treatment points on the incision surface on a first treatment path, and the treatment path being curved while extending around the projection axis of the focusing optics. In the event of a tilt of the eye with respect to the central axis of the patient interface, the circuit determines an apex of a tilted incision surface by a co-tilt of the incision surface corresponding to the tilt of the eye, and determines a transformed treatment path, which extends around the apex and determines treatment points on the tilted incision surface.

A laser surgical system comprises a laser source, scanners, delivery optics, and a computer. The laser source generates a beam of femtosecond laser pulses. The scanners direct focus spots of the beam towards points of a cornea. The delivery optics focuses the focus spots at the points of the cornea. The computer creates an incision in the cornea by instructing the optics and scanners to: direct and focus the focus spots from a posterior corneal surface, through a convex curve and a concave curve, to an anterior corneal surface to form an S-curve incision with a posterior end and an anterior end. The S-curve incision has a substantially non-planar rectangular shape with a longer side that extends from the posterior end to the anterior end and defines a longer direction. A cross-section of the incision in the longer direction exhibits the convex curve and the concave curve.

An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.

The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

In an ophthalmic laser procedure, a lenticule is formed in the cornea and extracted from the cornea to accomplish vision correction. The ophthalmic laser system is used to form top and bottom lenticule incisions which intersect each other to form an isolated volume of corneal tissue in between. The volume of tissue includes a lenticular portion having a circular or oval shape and a side tab that protrudes from the peripheral of the lenticular portion. The side tab has a radial dimension between 0.5 and 5 mm and a width between 0.5 and 3 mm in. An entry cut is further formed from the anterior corneal surface to the top or bottom lenticule incisions to provide access to the lenticule. During extraction, the surgeon uses the surgical tool to grab the side tab to extract the lenticule.