Methods for targeted therapy are disclosed. In certain embodiments, a method includes injecting nanoparticles into a target site in or adjacent to an eye, irradiating the target site with light from a light source, and activating the nanoparticles with the light.

An arrangement for OCT-based laser treatment of vitreous floaters. The arrangement for OCT-based laser vitreolysis includes an OCT system, a laser system having a deflection unit, optical elements that couple the OCT system and the laser system, a display unit and a central control and operating unit. The OCT system is configured to localize the floaters, the laser system is configured to destroy the floaters by application of laser pulses and the central control and operating unit is configured to determine apart from the coordinates of the localized floaters also their distance to structures of the eye, to derive exclusion criteria for the treatment, to align the deflection unit of the laser system to these coordinates and to focus and activate the laser system. The present invention relates to an arrangement for the gentle, low risk and painless laser treatment of vitreous floaters, which enables partially or fully automated therapy.

Described herein is a device for performing scleral depression. The device can include a ring and one or more arms protruding from the ring. The ring can define an opening over an eye and include a handle protruding away from the one or more arms. The opening can have a diameter that is at least 6 to 8 millimeters (mm) long. The one or more arms can be configured to be disposed over a globe of the eye for controllable depression of a sclera of the eye. Uniform pressure can be applied to the sclera by depression features at a distal end of each of the one or more arms.

A modular ophthalmology device comprising: a first optical device having a light source and an imaging sensor, a first input coupling having an optical interface connection and a physical interface connection for aligning and securing an input optical module, a first optical output, an optical pathway and an output coupling securing a third optical device.

In certain embodiments, an ophthalmic procedure contact lens for ophthalmic treatment of an eye with a laser beam includes a frame, an objective lens, and an illumination ring. The frame has an eye end, an operator end, and a flange-like shape with an interior region. The eye end is configured to be disposed outwardly from the eye. The objective lens is disposed within the interior region of the frame. The objective lens transmits the laser beam through the eye end to treat the eye. The illumination ring is coupled to the frame and provides annular illumination through the eye end to illuminate the eye. The illumination ring includes a ring substrate and light emitters coupled to the ring substrate. The light emitters emit light.

Certain embodiments provide an apparatus comprising a hand-piece, an outer tube coupled to the hand-piece, an inner tube housed within the outer tube and having a distal end coupled to a soft tip and a proximal end coupled to an adapter, a proximal end of the adapter coupled to a distal end of a valve, the valve slidably coupled to the hand-piece, and a core slidably coupled to the hand-piece and having a distal end coupled to a proximal end of the valve. To retract the soft tip, the valve is retracted, causing the adapter, the valve, and the core to slidably retract in a proximal direction in relation to the hand-piece, and to extend the soft tip, the valve is protracted, causing the adapter, the valve, and the core to slidably protract in a distal direction in relation to the hand-piece.

A method of recalibrating the focus of an ophthalmological laser treatment system. A target laser beam is focused on at least one target structure ZS.sub.1 in the eye to be treated by changing distance A between the laser treatment system and the eye until it is detected that the target laser beam of the laser treatment system is focused on the target structure ZS.sub.1. For selected values of a change in distance A between the laser treatment system and the eye, each focus position PF to be adopted of the laser beam in the OCDR signal profile is estimated approximately, using the parameters A.sub.1 and PZS.sub.1, on the basis of the distance A.sub.1 of the position of a selected reference structure PRS, as well as on the basis of the position of the target structure PZS.sub.1 in the OCDR signal profile, in each case relative to a reference plane RE.

A composition includes particles for use in a method for the treatment of a vitreous disease or a vitreous disorder as a light sensitizing agent. Each particle has a surface selected for or adapted for providing mobility of the particle in the vitreous and for binding to collagen aggregates, such as floaters.

A method and system perform an ophthalmic procedure on an eye having an optical path from the lens to the retina. An image of at least part of the eye is received in a data processing unit. The image includes the optical path. The data processing unit determines keep out zone(s) and identifies undesirable feature(s) based on the image. The keep out zone(s) include the retina. The data processing unit also selects one of the undesirable feature(s) for removal. At least part of the undesirable feature is outside of the keep out zone(s). Confirmation for removal of the undesirable feature is received in the data processing unit. In response to receiving the confirmation, a control unit controls a laser to perform laser removal the at least the portion of the undesirable feature without targeting any portion of the keep out zone(s).

A system for treating a media opacity in a vitreous media of an eye includes a visualization module adapted to provide visualization data of a portion of the eye via one or more viewing beams. The system includes a laser module adapted to selectively generate a treatment beam directed towards the media opacity in order to disrupt the media opacity. The laser module and the visualization module have a shared aperture for guiding the treatment beam and the one or more viewing beams towards the eye, the shared aperture being centered about a central axis. A controller is configured to acquire one or more defining parameters of the media opacity and determine when the media opacity is with a predefined target zone of a real-time viewing window. The media opacity is treated with the treatment beam when the media opacity is within the predefined target zone.