This invention provides a hydrogel surgical dressing product having a designed multi-dimensional flexible hydrophilic structure-linkage composite, comprising: a hydrogel cushion layer, and a multiple of hydrophilic microsphere, wherein said multi-dimensional flexible hydrophilic structure-linkage composite comprising a hydrophilic multi-dimensional flexible structure-linkage membrane, and a multiple of structure-linkage holes positioned into said hydrophilic multi-dimensional flexible structure-linkage membrane, and the sizes of structure-linkage holes changed with the degree of compelling force, resulting in a multi-dimensional flexible structure-linkage relationship and a consolidating structure.

The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.

Method for the manufacture of a wound care product in which a fabric containing hydroactive constituents, in particular fibres, is processed, whereby the processing of the fabric comprises the application of an antimicrobial means onto the hydroactive constituents.

Wound dressings provide a tenacious occlusive seal against the skin of a wearer, even in the presence of excessive blood or heavy perspiration. The preferred embodiment uses a hydrogel island providing superior hydrophilic gel adhesion. The product performs under extreme temperatures (i.e., 32-140 F.), and may be used to hold other dressings in place. Different vented embodiments are disclosed. A preferred structure includes a cover layer peripherally bonded to backing and hydrogel layers having a central aperture therethrough. The cover layer may have one or more holes, passages, tunnels or pockets to release pressure from a wound through the central aperture to the ambient environment. Layers that come in contact with blood products are preferably anti-thrombogenic to reduce or eliminate thrombi, or clotting that might interfere or obstruct venting. In particular, blood-contacting cover and cover/backing layers may use a thermoplastic polyurethane (TPU) film, more particularly a polyether TPU film.

The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.

The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.