Disclosed is a composition for disinfecting the hands, including: a) at least one alcohol including from one to four carbon atoms, b) at least one water-in-oil emulsion containing: —a crosslinked anionic polyelectrolyte (P); —a fatty phase consisting of at least one oil (H), —water, —a water-in-oil emulsifying system (S.sub.1), and—an oil-in-water emulsifying system (S.sub.2); c) at least one compound of formula (II): R.sub.2—(C═O)—O—(CH.sub.2—CH.sub.2—O).sub.x—CH.sub.2—CH[(O—CH.sub.2—CH.sub.2).sub.y—O—(C═O)—R.sub.3]—CH.sub.2—(O—CH.sub.2—CH.sub.2).sub.2—O—(C═O)—R.sub.4 (II), wherein R.sub.2—(C═O), R.sub.3—(C═O) and R.sub.4—(C═O), identical or different, represent a saturated or unsaturated, linear or branched acyl group including from 16 to 24 carbon atoms, and wherein the sum x+y+z is greater than or equal to 30 and less than or equal to 100; and d) water.

A skincare formulation for reducing facial expression lines via multi-modal reduction of ACh concentration and activity. The formulation includes a carrier base, an inhibitory neurotransmitter and a plurality of neuromodulating peptides configured to inhibit ACh concentration and activity at the epidermis as well as at the neuro-muscular junction The inhibitory neurotransmitter is configured to reduce neuronal excitability. The plurality of neuromodulating peptides includes a first neuromodulating peptide configured to compete with SNAP-25 in the SNARE complex of the motor neuron at the presynaptic terminal, a second neuromodulating peptide configured to destabilize the SNARE complex at the presynaptic terminal, a third neuromodulating peptide configured to inhibit fusion of ACh vesicles in neuron plasma membrane, a fourth neuromodulating peptide configured to inhibit contraction of muscles via inhibition of transmitter-gated ion channel communication at the postsynaptic membrane, and a fifth neuromodulating peptide configured to block reception of ACh at the muscle cell, the postsynaptic membrane.

A composite particle includes a core particle having a pore and fine fibers inseparably bonded to a surface of the core particle. The fine fibers are at least either cellulose nanofibers or chitin nanofibers.

A cosmetic composition including a water phase, the water phase comprising solubilized 4-hydroxyacetophenone with niacinamide, wherein the weight ratio of niacinamide to 4-hydroxyacetophenone in the water phase is greater than 3.0.

The present invention relates to a composition in the form of an O/W emulsion, comprising: (a) at least one cationic polysaccharide; (b) at least one crosslinker having three or more acid groups or salt thereof; (c) at least one oil; and (d) water, wherein the amount of the (c) oil(s) in the composition is 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more, relative to the total weight of the composition. The composition in the form of an O/W emulsion according to the present invention is stable. Also, a composition in the form of an O/W/O emulsion can be prepared by the composition in the form of an O/W emulsion according to the present invention.

According to the invention, a cosmetic gel is provided comprising multilamellar vesicles dispersed in an aqueous phase, wherein the multilamellar vesicles have the shape of a rotational body comprising two or more concentric lipid double layers, the cosmetic gel comprising: a) a surfactant component, comprising at least one vesicle-forming surfactant, which is a surfactant having a HLB value of greater than 6; b) an oily phase comprising a triglyceride oil; c) an aqueous phase comprising a water-soluble polyhydric alcohol;
and wherein the multilamellar vesicles have a median particle size d(50) from 50 to 800 nanometres and wherein the particle size distribution is Gaussian and the standard deviation is less than 30% of the median particle size d(50).

The present invention relates to a composition in the form of an O/W emulsion, comprising: (a) at least one cationic polysaccharide; (b) at least one crosslinker having three or more acid groups or salt thereof; (c) at least one oil; and (d) water, wherein the amount of the (c) oil(s) in the composition is 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more, relative to the total weight of the composition. The composition in the form of an O/W emulsion according to the present invention is stable. Also, a composition in the form of an O/W/O emulsion can be prepared by the composition in the form of an O/W emulsion according to the present invention.

A method for making a composition for enamel regeneration proposes to encapsulate soluble calcium and phosphate salts within corresponding internal water phases in respective water-in-oil-in-water emulsions stabilized by solid particles, and add them to a toothpaste, enamel restoring gel or mouth wash base. In this way, the soluble calcium and phosphate salts can be present stably in the toothpaste, enamel restoring gel or mouth wash over a long period of time. When the toothpaste, enamel restoring gel or mouth wash of the present disclosure is used in oral cavity, the water-in-oil-in-water emulsions rapture under the effect of friction and pressing, releasing the soluble calcium and phosphate salts encapsulated within the corresponding internal water phases. As a result, the liquid in the user's oral cavity will contain high concentrations of calcium and phosphate ions, which can enhance the rate of enamel remineralization.

A method for making a toothpaste enabling enamel restoration proposes to encapsulate soluble calcium and phosphate salts within corresponding internal water phases in respective water-in-oil-in-water emulsions. In this way, the soluble calcium and phosphate salts can be present stably in the toothpaste over a long period of time without causing precipitation of calcium phosphate. When the toothpaste of the present disclosure is used in brushing teeth, the water-in-oil-in-water emulsions are ruptured under the effect of friction and pressing, releasing the soluble calcium and/or phosphate salts encapsulated within the corresponding internal water phases. As a result, the liquid in the user's oral cavity will contain high concentrations of calcium and phosphate ions, which can enhance the rate of remineralization of enamel and/or dentin exposed to the oral cavity.

A dermatological preparation comprises an optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents and the use of said preparation for skin care, hair care, or body care, or dental procedures, or for regenerative medicine such as promoting wound or bone healing. The preparation is formulated to target the hypoxic microenvironment niches of the skin tissue in combination with optimal concentration of nutrients, ions and minerals; to stimulate existing stem cells to trigger the capacity of stem cells to divide and renew and differentiate into specialized cells; and to stimulate molecular and physiological processes, e.g., autophagy, to replenish the substrate pool through the recycling of organelles and the recycling of old damaged proteins and countering free-radical damage to promote anti-aging.