A device is disclosed that includes a bone stent positioned within a bony access channel formed within a vertebra. The bony access channel may extends from an outer end of the vertebra through an endplate. The device includes an end cap attached to a proximal end portion of the bone stent and is configured to, post-operatively, open to allow a reintroduction of a material to a spinal intradiscal space or intervertebral disc and to seal access to the spinal intradiscal space or the intervertebral disc after the reintroduction of the material.

A device is disclosed that includes a bone stent positioned within a bony access channel formed within a vertebra. The bony access channel may extends from an outer end of the vertebra through an endplate. The device includes an end cap attached to a proximal end portion of the bone stent and is configured to, post-operatively, open to allow a reintroduction of a material to a spinal intradiscal space or intervertebral disc and to seal access to the spinal intradiscal space or the intervertebral disc after the reintroduction of the material.

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

A device is disclosed that includes a bone stent positioned within a bony access channel formed within a vertebra. The bony access channel may extends from an outer end of the vertebra through an endplate. The device includes an end cap attached to a proximal end portion of the bone stent and is configured to, post-operatively, open to allow a reintroduction of a material to a spinal intradiscal space or intervertebral disc and to seal access to the spinal intradiscal space or the intervertebral disc after the reintroduction of the material.

A device is disclosed that includes a bone stent positioned within a bony access channel formed within a vertebra. The bony access channel may extends from an outer end of the vertebra through an endplate. The device includes an end cap attached to a proximal end portion of the bone stent and is configured to, post-operatively, open to allow a reintroduction of a material to a spinal intradiscal space or intervertebral disc and to seal access to the spinal intradiscal space or the intervertebral disc after the reintroduction of the material.

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring. The template may have an outwardly-facing groove to receive and retain the ring.