The objective of the present disclosure is a multi-component packaging unit (kit-of-parts) for dyeing keratinous material, in particular human hair, comprising separately prepared a first container comprising an agent (a), wherein the agent comprises (a): (a1) at least one amino-functionalized silicone polymer, and a second container comprising an agent (b), wherein the agent comprises (b): (b1) Water and (b2) a buffer system comprising at least one inorganic or organic acid (b2-I) and at least one salt of this acid (b2-II), and (b3) at least one color-imparting compound. A second objective of the present disclosure is a corresponding method in which the two agents (a) and (b) are used.

A composition for dyeing keratin fibres comprising a. at least one azomethine compound selected from compounds (3) and (4) and b. water. The composition may be used in a process for dyeing keratin fibres or, with simultaneous or sequential application of a composition comprising one or more oxidising agents, in a process for lightening keratin fibres.

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The subject of the present application is an agent for the oxidative dyeing of keratinous fibers, in particular human hair, which contains in a cosmetic carrier (A) at least one oxidation dye precursor with 4,5-diaminopyrazole as the basic structural element according to the structural formula (I) and furthermore (B) glucoheptonic acid and/or at least one of its physiologically tolerated salts and/or lactones. The composition as contemplated herein further comprises (C) at least one oxidizing agent other than atmospheric oxygen.

The present invention relates to a stable liquid composition comprising hair direct dyes in a liquid diol which is used for dyeing hair after mixing with one or more other aqueous compositions. The compositions preferably comprise an alkalizing agent.

The present disclosure provides the use of cyclin-dependent kinase (CDK) inhibitors, specifically CDK9 and/or CDK5 inhibitors, in the manufacture of compositions for the slowdown or prevention of biological aging. The inhibition of CDK9 and/or CDK5 activity in particular prevents the phosphorylation of DNA-proximal amino acid residues in the linker histone variants H1.0 (also known as H1 histone family, member 0) and H1x (also known as H1 histone family, member X). Because these specific phosphorylation events are prevented, critical higher-order constraints on chromatin dynamics in adult cells are significantly stabilized-- a time-related imbalance of these constraints has been proposed to be the fundamental cause of biological aging. The resulting stabilization of higher-order constraints on chromatin dynamics thus makes the use of CDK9 and/or CDK5 inhibitors suitable for conferring significant resistance to biological aging.

An agent for dyeing keratin fibers comprises a composition A comprising at least one alkalizing agent, at least one oxidative dye precursor, at least one surfactant and at least one fatty substance free of carboxylic acid groups and a composition B comprising at least one oxidizing agent and at least one surfactant. The concentration of fatty substances free of carboxylic acid groups after mixing composition A and composition B is at least 20% by weight relative to the total weight of the mixed composition A and B. The concentration of alkalizing agent after mixing composition A and composition B is not more than 1.75% by weight relative to the total weight of the mixed composition A and B.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

Composition comprising at least two anionic surfactants, a nonionic surfactant, an amphoteric surfactant, and at least one direct dye The present invention relates to a composition for the cosmetic treatment of keratin fibres, in particular of the hair, comprising at least two anionic surfactants, at least one nonionic surfactant, at least one amphoteric surfactant and at least one direct dye. The invention also relates to a cosmetic process for treating keratin fibres, especially for dyeing the hair, using such a composition, and also to a use of said composition.

The present invention relates to a composition for dyeing keratin fibres, comprising an oxidation base, a 2-amino-5-ethylphenol coupler and at least 20% by weight of fatty substance relative to the total weight of the composition. The invention also relates to a process for dyeing keratin fibres using this composition. Finally, the invention relates to the use of such a composition for dyeing keratin fibres, and in particular the hair.

A method for determining a correspondence between hair coloring agents and hair coloring results is provided. The method includes obtaining hair color data. Further, the method includes splitting hair color data into a first hair color group and a second hair color group, the first hair color group comprising more data than the second hair color group. The method also includes adding artificial hair color data to the second hair color group. The method further includes building a model by employing predictive analytics based on the hair color data and including the artificial hair color data.