The present application relates to sunscreen formulations, including foamable sunscreen formulations, that comprise zinc oxide and titanium dioxide particles, suitably in the size range of about 1-100 nm. The compositions suitably produce a minimal residual whitening effect when applied to a skin surface.

This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

According to the present invention there is provided composition in the form of an oil-in-water emulsion having a viscosity of between 15,000 cP (15 Pa-s) and 45,000 cP (45 Pa-s) at 23 C., having a pH of between 2 and 6 and comprising: (i) at least 1.6 wt. % of at least one cross-linked anionic polyelectrolyte resulting from the polymerisation of partially or completely salified 2-methyl 2-[(1-oxo 2-propenyl)amino]1-propane sulfonic acid, with at least one neutral monomer chosen from the N,N-dialkyl acrylamides, wherein each of the alkyl groups comprises between one and four carbon atoms, and at least one monomer of formula (B): wherein R represents a linear or branched alkyl radical comprising eight to twenty carbon atoms and n represents a number greater than or equal to one and less than or equal to twenty, in the presence of at least one cross-linking agent; (ii) at least 4 wt. % of at least one polysorbate; (iii) at least 0.1 wt. % of at least one polysaccharide gum; and (iv) between 6 wt. % and 30 wt. % water. The present invention also provides a composition as defined above obtainable by a process comprising the following steps: (a) in one vessel, homogenising the polysaccharide gum (iii) into the aqueous phase comprising the water at a temperature of between 60 C. and 90 C.; (b) in a vessel separate from that in (a), homogenising the cross-linked anionic polyelectrolyte (i) and the polysorbate (ii) into the oil phase at a temperature of between 60 C. and 90 C.; and (c) combining the ingredients of (a) with the ingredients of (b) through homogenisation at a temperature of between 60 C. and 90 C. ##STR00001##

The present invention relates to an oral composition having improved ability of incorporating fluoride ions into tooth enamel and an enhanced remineralization effect. That is, the present invention provides an oral composition comprising an ingredient (A): 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; an ingredient (B): 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol; an ingredient (C): 0.1 mass % or more and 10 mass % or less of a surfactant comprising one or more selected from the group consisting of (c1) a nonionic surfactant selected from the group consisting of sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester and (c2) an anionic surfactant being fatty acid having 12 or more and 22 or less carbon atoms or a salt thereof; and an ingredient (D): water, wherein the content of the ingredient (c1) is a specific level or more; and the mass ratio of the content of the ingredient (A) in terms of fluorine atoms to the content of the ingredient (B), (A)/(B), and the molar amount of (E) a polyvalent metal compound other than the ingredient (A) are specific values.

The invention describes novel compositions and methods utilized for treating disorders and/or conditions associated with the epidermal and/or dermal level of the skin. Such disorders include hyperhidrosis, bromhidrosis, and chromhidrosis, One representative composition of the invention comprises; water, alcohol, aluminum sesquichlorohydrate, hydroxypropyl methyl cellulose, polysorbate 20, isopropyl myristate, eucalyptus oil, silicone oil, alkyl benzoate, glycerine, talc, a hydrophillic silica, a hydrophobic silica, phenoxyethanol and ethylhexyl glycerine.

Disclosed is a personal care composition comprising: (a) a cationic or nonionic surfactant; (b) a high melting point fatty compound having a melting point of from 25? C. to 60? C. (c) a solid organic compound having a water solubility of lower than 25 g per 1 liter water, and having a melting point of exceeding 60? C., and also having a specific AlogP; (d) a first liquid oily compound other than a second liquid oily compound, wherein the first liquid oily compound has a water solubility of 10 g per 1 liter water or less, wherein a mixture of all the first liquid oily compounds included in the composition has a di-electric constant of from about 5 to about 10, and wherein the weight ratio of the solid organic compound to the first liquid oily compound is from about 1:1 to about 1:10; and (e) an aqueous carrier, wherein the composition comprises 0.1% or less of a second liquid oily compound having a higher AlogP of 7.0 or higher. The composition of the present invention provides improved deposition of the solid organic compound and/or reduced crystallization of the solid organic compound in the composition.

The present invention relates to compositions comprising and methods for use of formulations for the delivery of cosmetic agents, including anionic polymers such as hyaluronic acid with cosmetic activity. They are useful in, e.g., cosmetics and pharmaceuticals that prevent or improve the appearance of undesirable skin features including wrinkles or enhancing lip fullness.

Disclosed are antiseptic compositions for disinfecting tissues, in particular for ocular use. Methods and compositions disclosed herein include sodium chlorite, optionally in combination with a surfactant.

Disclosed are antiseptic compositions for disinfecting tissues, in particular for ocular use. Methods and compositions disclosed herein include sodium chlorite, optionally in combination with a surfactant.

The invention relates to an alcohol-free cosmetic or therapeutic foam carrier comprising water, a hydrophobic organic carrier, a foam adjuvant agent, a surface-active agent and a gelling agent. The cosmetic or therapeutic foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble therapeutic and cosmetic agents.