Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 2537 C. as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without lyophilization process.

This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

A purpose of the present invention is to provide an oil-in-water emulsion cosmetic having a fresh feeling in use like that of a skin-care cosmetic such as a milky lotion, while also allowing titanium oxide or zinc oxide, which are ultraviolet scattering agents, to be stably blended into the oil phase, and also providing excellent sunscreen effects. The present invention relates to an oil-in-water emulsion cosmetic characterized by comprising (A) an ultraviolet scattering agent having a hydrophobic surface; (B) a water-soluble alkyl-substituted polysaccharide derivative; (C) a higher alcohol; and (D) a non-ionic surfactant. The emulsion cosmetic of the present invention preferably has a viscosity, measured by a B-type viscometer at 30 C., of 12,000 mPa.Math.s or lower.

Described are effervescent dissolvable solid structures having fibers formed from a composition comprising surfactant and water soluble polymeric structurant, having a total dissolvable solid structure density of from about 0.100 g/cm.sup.3 to about 0.380 g/cm.sup.3, having a surfactant dose of from about 0.5 to about 2.0 g, and a surfactant density of from about 0.1 g/cm.sup.3 to about 0.3 g/cm.sup.3. Also described are processes for manufacturing the Dissolvable Solid Structure.

Lecithin based microemulsion and their uses as nanoreactors and carrying materials are disclosed. In one embodiment, a method of forming a nanomaterial comprises mixing a lecithin based microemulsion with a first reactant and a second reactant. In a further embodiment, a method for encapsulating a nanomaterial in a lecithin based microemulsion forming a composition and wherein the composition forms a dispersion in an aqueous solution, polar solution, or a non-polar solution.

The present application relates to sunscreen formulations, including foamable sunscreen formulations, that comprise zinc oxide and titanium dioxide particles, suitably in the size range of about 1-100 nm. The compositions suitably produce a minimal residual whitening effect when applied to a skin surface.

The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.

Dry mixtures and liquid formulations are provided that comprise metal oxide and/or metal hydroxide nanocrystalline particles. The dry mixtures are advantageously formulated with select surfactants to be readily solubilized and stable in liquid carriers. Additional select components are provided in preferred combinations that are capable of achieving improved biocidal and chemical agent efficacy. Notably, the inventive formulations provided herein allow for easier delivery of the formulations and increased shelf stability.

The subject application relates to a liquid thickener composition comprising polyalkoxylated polyols polyester having Guerbet acid moieties. Compounds contained herein relate to polyalkoxylated polyol polyester having a viscosity that allows a product to be poured, yet retained on a desired surface to which it is applied. Embodiments of the compounds may be exemplified by the formula:

Q-[(OA).sub.nOR].sub.m