The present invention relates to a novel compound conjugated with naringenin and lipoic acid which are linked with a linker, and a use thereof.

Tablets are prepared with friability reducing agents to yield tablets that are more resistant to breakage or crumbling, but with satisfactory hardness. The friability reducing agents include low molecular weight polyethylene glycol as well as similar agents exhibiting at least three percent (3%) hydroxide moieties and a water solubility of at least eighty percent (80%) (w/w %) in room temperature water. The tablets may comprise an active agent and excipient of almost any type, and about 0.1-about 0.5% by weight friability reducing agent. They exhibit a hardness of at least eighty percent (80%) of the same tablet prepared without the friability reducing agent.

A cosmetic composition is provided. The cosmetic composition comprises a carboxylic acid modified silicone (A) that has a specific chemical structure and is liquid at room temperature. The cosmetic composition also comprises an oil agent (B). The cosmetic composition generally provides a cosmetic film having excellent water resistance, and can be easily removed by normal soap and water.

Disclosed are antiseptic compositions for disinfecting tissues, in particular for ocular use. Methods and compositions disclosed herein include sodium chlorite, optionally in combination with a surfactant.

A multi-phase oral composition with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier, which is rinseable from a surface and/or has a high water dispersibility. A jammed oil-in-water composition with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier, which is rinseable from a surface and/or has a high water dispersibility. Methods of using disclosed compositions for active agent delivery.

Water-soluble refill dose articles for forming a cleanser have a water-soluble film defining a first compartment enclosing a first composition and a second compartment enclosing a second composition, which are individual separate articles or are part of an integral article. The first composition has a rheology modifier, a first surfactant, 10% or less by weight water, 20% or less by weight glycol, and the first surfactant does not activate the rheology modifier. The second compartment has an alkaline substance that when mixed with the first composition and water activates the rheology modifier to increase the viscosity of a resulting cleanser and 10% or less by weight water. When the article is diluted in water at a 1:1 to 1:20 ratio, it produces a cleanser having a viscosity within a range of 2000 cps to 50,000 cps.

The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

Disclosed is a method for preparing an ultraviolet radiation absorbing polymer composition comprising the polymer compound of formula ##STR00001##
in an esterification/transesterification which method comprises the steps of reacting a polyglycerol intermediate of formula ##STR00002##
with a benzotriazole UV-chromophore comprising a complementary functional group of formula ##STR00003##
to form the polymer compound of formula (3).

A coating composition, an elastomeric article having the coating composition and a process for making coated elastomeric articles are disclosed in the present invention. The coating composition comprises 0.5% to 11% by weight/volume of at least one cooling agent; 0.5% to 11% by weight/volume of at least one non-ionic surfactant; and water, wherein rest of the coating composition is made of water. The coated elastomeric articles prepared according to the present invention improve user's sensory experience of wearing the elastomeric articles for long durations without varying the user's hand temperature or limiting mobility of the user's hand.

According to the present invention there is provided composition in the form of an oil-in-water emulsion having a viscosity of between 15,000 cP (15 Pa-s) and 45,000 cP (45 Pa-s) at 23° C., having a pH of between 2 and 6 and comprising: (i) at least 1.6 wt. % of at least one cross-linked anionic polyelectrolyte resulting from the polymerisation of partially or completely salified 2-methyl 2-[(1-oxo 2-propenyl)amino]1-propane sulfonic acid, with at least one neutral monomer chosen from the N,N-dialkyl acrylamides, wherein each of the alkyl groups comprises between one and four carbon atoms, and at least one monomer of formula (B): wherein R represents a linear or branched alkyl radical comprising eight to twenty carbon atoms and n represents a number greater than or equal to one and less than or equal to twenty, in the presence of at least one cross-linking agent; (ii) at least 4 wt. % of at least one polysorbate; (iii) at least 0.1 wt. % of at least one polysaccharide gum; and (iv) between 6 wt. % and 30 wt. % water. The present invention also provides a composition as defined above obtainable by a process comprising the following steps: (a) in one vessel, homogenising the polysaccharide gum (iii) into the aqueous phase comprising the water at a temperature of between 60° C. and 90° C.; (b) in a vessel separate from that in (a), homogenising the cross-linked anionic polyelectrolyte (i) and the polysorbate (ii) into the oil phase at a temperature of between 60° C. and 90° C.; and (c) combining the ingredients of (a) with the ingredients of (b) through homogenisation at a temperature of between 60° C. and 90° C.

##STR00001##