The present disclosure provides all-natural nano- or micro-emulsions for the treatment of the skin, hair follicles, and related conditions, methods of using such nano- or micro-emulsions, and methods for preparing such nano- or micro-emulsions. The present disclosure relates to nano- or micro-emulsion formulations with improved bioavailability, time of onset, cellular permeability, and viscosity that can be suitable for topical, sublingual, oral, and/or nasal administrations. The current disclosure also includes compositions and methods for improving the bioavailability and the onset of actions arising from the particular components within the nano- or micro-emulsion formulations of the present disclosure.

Disclosed herein are compositions and methods to increase glucose uptake and fat metabolism. The disclosed composition can comprise a PI3K agonist; a TRPM8 agonist; and a pharmaceutically, nutraceutically, or cosmetically acceptable carrier. Also disclosed is a method of treating diabetes, obesity, or metabolic syndrome in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist. Also disclosed is a method of treating a skin condition in a subject, comprising topically administering to a subject in need thereof an effective amount of a composition comprising a PI3K agonist and a TRPM8 agonist.

A cosmetic composition for improved penetration of skin active agents including about 0.1 to about 10 wt. % of C-glycoside; about 0.1 to about 5 wt. % of polyglyceryl-3 methylglucose distearate; about 0.1 to about 5 wt. % of sodium polyacrylate; and water, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition. Methods for treating damaged skin with cosmetic compositions are also disclosed.

A process for preparing a composition (C.sub.1) represented by the formula (I): HO—CH.sub.2—(CHOH).sub.n—CH.sub.2—O-(G).sub.x-H, in which G represents the remainder of a reducing sugar, n is an integer equal to 2, 3 or 4 and x, which indicates the mean degree of polymerization of the remainder G, represents a decimal number greater than 1 and less than or equal to 5, characterized in that the process includes at least one step a) of reacting a polyol of formula (A.sub.1): HO—CH.sub.2—(CHOH).sub.n—CH.sub.2—OH, in which n is an integer equal to 2, 3 or 4, with a reducing sugar of formula (II): HO-G-H, in which G represents the remainder of a reducing sugar, in the presence of an acid catalyst (C.sub.a), and in that the acid catalyst (C.sub.a) is chosen from phosphorous acid, phosphoric acid and polyphosphoric acid.

The invention relates to an extract of the aerial parts of Lawsonia inermis, as well as its preparation method and the extract that can be obtained by said method. The invention also relates to a cosmetic dye composition comprising such an extract. The invention finally concerns a cosmetic method for dying keratin fibers comprising the application of such a composition.

The present invention relates to an extemporaneous product for the preparation of dermatological and/or cosmetic compositions, this product comprising, on the one hand, one or several active substances and on the other, a universal base allowing such active substance or substances to be solubilised and comprising at least one oil rich in omega-3, water, glycerine, an alcohol other than glycerine, and emulsifier and a biomimetic peptide.

The present invention relates to oral care compositions comprising hyaluronic acid, which are useful for promoting oral mucosa repair and/or for reducing biofilm formation.

A cleansing composition and method of using a cleansing composition, the cleansing composition including a blend of three different emollients, the emollients including a first stearic ester, a second stearic ester, and a branched hydrocarbon, where the first stearic ester and second stearic ester are different from each other.

Disclosed is a composition based on a polyol of formula: HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—OH and on alkyl polyrhamnosides of formula: HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—O-(Rham).sub.x-H; process for preparing same, and cosmetic or pharmaceutical composition including same.

The present invention relates generally to methods of use and compositions useful to reduce dark spots, age spots, and/or unwanted pigmentation of skin. The composition includes a combination of niacinamide, phytic acid, Rosmarinus officinalis leaf extract, Chondrus crispus extract, and a combination of Saxifraga sarmentosa extract, Carica papaya (papaya) fruit extract, and Psidium guajava (guava) fruit extract. The composition is effective to reduce dark spots, age spots, and/or unwanted pigmentation of skin. The composition is effective to inhibit tyrosinase and/or Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) activity. The composition is further effective to reduce melanin content in skin, particularly dark skin, in some instances by at least 30%.