Compositions that supplement and support nitric oxide availability to skin and methods of use are provided herein.

The present invention relates to a method for preventing oxidation of polyphenols, materials thereof, and uses thereof, and more particularly, it relates to a method of preventing oxidation of catechins by treating catechins with aptamers, aptamers having such activity with preventing oxidation of catechins, and it relates to its application to various fields such as cosmetics, foods, and pharmaceuticals using the aptamer. The aptamer of the present invention has an antioxidant effect of catechins, so the aptamer of the present invention can be applied in various fields such as cosmetics, foods, and pharmaceuticals that require inhibition of oxidation of catechins.

A method of treating an osmidrosis condition in a subject can include administering a therapeutic agent in an amount that is effective to inhibit expression of an ABCC11 gene in a target cell of the subject to an osmidrosis-reducing level. A therapeutic composition for treating an osmidrosis condition in a subject can include a therapeutically effective amount of an ABCC11 gene-inhibiting agent and a pharmaceutically acceptable carrier.

A method to treat diseases or conditions associated with the human MMP-1 gene transcription involving administration of the peptide nucleic acid derivative according to claim 1 to a subject. The present invention provides the peptide nucleic acid derivative according to claim 1 which targets 5′ splice site of the human MMP-1 pre-mRNA “exon 5”. The peptide nucleic acid derivatives in the present invention strongly induce splice variants of the human MMP-1 mRNA in cell and are very useful to treat conditions or diseases of skin aging associated with the human MMP-1 protein.

A person's iris color can lighten, such as from brown to lighter brown, green, hazel, or blue, by introducing a melanocyte-killing agent through the cornea of the person's eye and contacting the anterior surface of the iris with the agent at a dose sufficient to kill melanocytes in the iris stroma.

Skin care compositions are provided which contain Thermus thermophilus ferment and silybin and provide anti-aging and reparative effect for skin. The compositions may also include one or more additional substances selected from carnosine, adenosine and CG-EDP3. The substances are dispersed in an aqueous carrier, such as water, to be applied to the skin in a spreadable form.

The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

The present invention relates generally to methods of use and compositions useful for treating skin to reduce the appearance of wrinkles, moisturize skin, lighten skin, reduce inflammation, increase skin firmness, or increase skin elasticity. The composition can include 20 wt. % to 45 wt. % light mineral oil, 0.1 wt. % to 5 wt. % Persea gratissima (avocado) oil, 0.1 wt. % to 5% wt. % Olea europaea (olive) fruit oil, 0.1 wt. % to 5 wt. % Argania spinosa kernel oil. 0.1 wt. % to 10 wt. % Limnanthes alba (meadowfoam) seed oil, 0.1 wt. % to 5 wt. % hybrid sunflower oil, 0.01 wt. % to 5 wt. % Crambe abyssinica seed oil, and 0.01 wt. % to 5% w/w of Daucus carota sativa (carrot) root extract.

Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.

PROBLEM: To provide a cosmetic composition that has a moisturizing effect that gives lasting moisture to a skin, an effect that prevents or improves aging symptoms, such as wrinkles and sags, and similar effect.

SOLUTION: Nicotinamide mononucleotide is contained in a cosmetic composition.