A substrate holder for a lithographic apparatus has a planarization layer provided on a surface thereof. The planarization layer provides a smooth surface for the formation of an electronic component such as a thin film electronic component. The planarization layer may be provided in multiple sub layers. The planarization layer may smooth over roughness caused by removal of material from a blank to form burls on the substrate holder.

Oral appliances, and systems and methods, which include oral appliances are described herein. An example oral appliance device for treatment of a sleep disorder or condition in a subject can include an upper portion configured to receive at least one maxillary tooth of the subject, and a lower portion configured to receive at least one mandibular tooth of the subject. The upper and lower portions are engageable such that the portions maintain a restricted orientation relative to each other when engaged, and the engaged restricted orientation is configured to maintain the mandible of the subject in a predetermined clinically beneficial orientation relative to the maxilla.

A structure for optically aligning an optical fiber to a protonic device and method of fabrication of same. The structure optically aligns an optical fiber to the protonic device using a lens between the two which is moveable by actuator heads. The lens is moveable by respective motive sources associated with the actuator heads.

A closing dressing bolster and assembly for use with a system for treating a linear wound on a patient includes a bolster body formed from a flexible closing bolster material having closing members that are operable to develop an inward closing force when the closing dressing bolster is placed under reduced pressure. In one aspect, when the closing dressing bolster is under reduced pressure, the system, dressing, or assembly develops an inward force realized at the linear wound and a compression force. A wicking-material holder and wicking material may be used as well. The member components may all be see-through to allow visual inspection of the wound without requiring removal of the dressing.

The present disclosure concerns an indication mechanism for an automatic applicator, particularly for insulin or other liquid preparations, particularly for multiple injection administration of set doses of a medicine from an exchangeable container, for example for the self-application of insulin by diabetes patients. An indication mechanism for an automatic applicator, having an assembly of at least two barrels movably coupled to each other has an indication barrel mounted on the driving barrel contains only marking on its external surface and is co-axially connected to the pull-push control nut.

One aspect of this disclosure provides a heat exchanger that comprises a first panel half coupled to a corresponding second panel half that form a passageway having at least a first chamber adjacent an inlet end of the passageway and a second chamber and overlapping interference patterns formed in each of the first and second panel halves that extend along at least a portion of the length of the passageway and located between at least the first and second chambers.

A guide pin assembly for metal forming dies includes a cylindrical guide pin body with an external retainer groove adjacent one end thereof in which a retainer ring is received. An annular guide pin ring with an outside diameter greater than the pin body, has a counterbore adjacent the outside end thereof and a retainer groove in a medial portion thereof which receives the outer portion of the retainer ring to securely interconnect the pin body and the ring and thereby form an enlarged head at one end of the pin body which positively limits reciprocal motion between two associated die members. A circular guide pin head cap covers the outer end of the head ring, and includes a support collar that is closely received in the counterbore of the ring, and engages the retainer ring to securely hold the same in place.

Embodiments of the invention include devices and methods for implanting arthroplasty devices. Some embodiments include designs that allow for use of x-ray images as the only images used to fully and accurately preoperatively and intraoperatively size and align arthroplasty device components and prepare all necessary tissue.

An apparatus for securing a vertebra during healing of a fracture within a pars area of the vertebra is described. In certain embodiments, the apparatus is a plate that has an outer shape similar to a shape of a pedicle and/or lamina of the vertebra, and an inner section that facilitates access to the pars area when the plate is secured to the vertebra.

Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.