Personal care devices (or apparatuses) are described to deliver/activate a bioactive compound/botanical compound/biologically active molecule (including a regulatory protein/growth factor) or a mixture of bioactive compounds/botanical compounds/biologically active molecules (including regulatory proteins/growth factors) for growth and protection of hair or rejuvenation and protection of skin, which utilizes nanoencapsulation/nanoemulsion and/or activation/photoactivation. Such devices (or apparatuses) utilize a light low intensity module/x-ray and nanooptical elements/three-dimensionally (3-D) printed micro/nanostructures. Furthermore, the personal care devices (or apparatuses) can be enhanced with an artificial intelligence (AI) algorithm and/or augmented reality (AR) application (app).

A method of cleaning a surface having disposed thereon a soil comprising fatty acid, the method comprising contacting the soil with a consumer product composition comprising a surfactant and a soil transforming enzyme selected from the group consisting of hydroperoxy fatty acid producing enzymes, hydroperoxy fatty acid converting enzymes, multi-domain enzymes, hydroxy fatty acid producing enzymes, and mixtures thereof. The method further comprises converting the fatty acid of the soil into an active fatty acid derivative material selected from the group consisting of hydroperoxy fatty acids, hydroperoxy fatty acid derivatives, hydroxy fatty acids, and mixtures thereof. Consumer product compositions are also provided.

A method of cleaning a surface having disposed thereon a soil comprising fatty acid, the method comprising contacting the soil with a consumer product composition comprising a surfactant and a soil transforming enzyme selected from the group consisting of hydroperoxy fatty acid producing enzymes, hydroperoxy fatty acid converting enzymes, multi-domain enzymes, hydroxy fatty acid producing enzymes, and mixtures thereof. The method further comprises converting the fatty acid of the soil into an active fatty acid derivative material selected from the group consisting of hydroperoxy fatty acids, hydroperoxy fatty acid derivatives, hydroxy fatty acids, and mixtures thereof. Consumer product compositions are also provided.

The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.

The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.

The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising effective amounts of one or more biofilm degrading enzymes in combination with antimicrobial agents or antimicrobial essential oils. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In a preferred aspect the invention provides a composition and method for use in the treatment or prevention of a biofilm infection in a subject, particularly in the oral cavity.

Disclosed are compositions comprising one or more enzymes capable of catalysing the hydrolysis of keratinocyte effector molecules such as protein keratins that support the function and integrity of the human skin and its appendages such as the hair follicle that are supported by keratinocytes to maintain the biological barrier, function and struture. The compositions are useful in treating follicular dermatoses and hair follicle-linked conditions, such as Hirsutism and Hidradenitis suppurativa. The compositions may also be used to loosen hair from the skin and thereby be used for removing undesired hair from the human body.

Disclosed are compositions comprising one or more enzymes capable of catalysing the hydrolysis of keratinocyte effector molecules such as protein keratins that support the function and integrity of the human skin and its appendages such as the hair follicle that are supported by keratinocytes to maintain the biological barrier, function and struture. The compositions are useful in treating follicular dermatoses and hair follicle-linked conditions, such as Hirsutism and Hidradenitis suppurativa. The compositions may also be used to loosen hair from the skin and thereby be used for removing undesired hair from the human body.

Antimicrobial preservative compositions that can be incorporated in products to be preserved are disclosed herein. The disclosed compositions include immobilized biocidal enzymes, such as cross-linking enzymes or active enzymes falling into the zymogen-class, for the purpose of modifying amino acid residues on a protein or binding a molecule of interest to a protein. The compositions include enzymes that are immobilized on a polymeric solid support, which improve the shelf life of the enzyme and protect the enzyme from auto-cross-linking or other deterioration over extended storage periods. Also disclosed are methods of increasing the self-like of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed compositions into the product.

Botulinum toxin is combined with colloidal silver particles to provide improved compositions for use in medical and cosmetic treatments.