The present invention describes stable topical barrier compositions comprising primary polyamines and uses thereof for protecting the skin from external stressors, for improving skin's moisture and fort stimulating healing of the skin. These compositions may be used in a variety of cosmetic and therapeutic applications including for promoting wound healing, for reducing or preventing the formation of hypertrophic scar tissue, for reducing or preventing skin irritation and inflammation, for increasing skin's moisture and/or for reducing or preventing skin's signs of aging.

The present disclosure is directed to the use of a composition comprised of: (1) a first active blend of at least: (a) Jojoba oil/Macadamia seed oil esters; (b) squalene; (c) phytosteryl macadamiate; and (d) phytosterols; (2) a second active blend of at least: (e) EGF growth factor; (f) IGF-1 growth factor; (g) acidic FGF growth factor; (h) basic FGF growth factor; (i) VEGF growth factor; (j) vitamin B9; and (k) acetyl glutamine; and (3) a third active blend of at least: (l) an extract of lithothamnium calcareum; (m) pentylene glycol; (n) lactic acid; and (o) glycerin; (4) an emulsifier; and (5) a dermatologically acceptable carrier which, when applied onto skin, helps to positively influence inflammation, hydration, and keratinocyte hyperproliferation, thereby supporting skin barrier health, integrity, and functionality.

A moisturizing composition and an application thereof in the preparation of a moisturizing cosmetic product; each component in the formulation cooperates with the others to jointly provide the effects of increasing the moisture content of the skin and reducing the loss of moisture of the skin; compared with the efficiency of using a single component or several components alone, the efficiency of the present invention is significantly increased, indicating that compounding each component at a proper ratio produces a synergistic effect, thereby improving moisturizing efficiency.

Exemplary embodiments of methods and apparatuses for a composition for hair regrowth and hair growth stimulation are provided. In some exemplary embodiments, a composition is provided including approximately 40% to approximately 55% ethyl alcohol, approximately 40% to approximately 55% propylene glycol, approximately 2% to approximately 7% minoxidil, and approximately 0.005% to approximately 0.02% biotin. The composition can further include avocado oil, melatonin, aloe, lavender oil and hydroxypropyl cellulose. A method of making the composition and a roll-on applicator for applying the composition can also be provided.

The present invention provides a hair growth essence and its preparation method; including the following weight percentages of each component: water 89.24%, PEG-400 7%, dextran 1%, guanine 0.5%, MSM 1%, biotin tripeptide-1 0.01%, blue copper peptide 0.35%, panthenol 0.5%, zinc gluconate 0.1%, phenoxyethanol 0.15%, chlorphenesin 0.15%. The present invention also relates to the aforementioned preparation method of the hair growth essence. The components covered by the present invention are safe and non-toxic, the formulation is reasonable, containing effective ingredients such as PEG-400, citrulline, biotin tripeptide-1, blue copper peptide and zinc gluconate; it can effectively strengthen hair roots, regulate metabolism and promote new hair growth, while the main ingredient PEG-400 has a dispersive effect; blue copper peptide has the effect of improving skin repair ability, promoting skin absorption, deep skin wake-up and so on.

Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B.sub.3 compound and, optionally, one or more additional skin care actives to provide a skin health and/or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25? C. The pH of the low-pH composition can range from 2.0 to 5.0.

Provided is a hair growth-promoting composition comprising: 100 parts by weight of a stem cell culture solution obtained from a culture medium of mesenchymal stem cells which have been subcultured two or more times; 0.001 to 0.1 parts by weight of zinc; 5 to 50 parts by weight of a panthenol based compound; and 0.0001 to 0.1 parts by weight of a water-soluble vitamin, wherein it is sprayed or applied on the scalp to promote hair growth. Said hair growth-promoting composition may have an excellent effect and improve economical efficiency in treating alopecia due to a simple delivery method of the composition.

A skin care combination and manufacturing method thereof are provided. The skin care combination includes micro cluster water, ion compounds, vitamin, amino acid, carbon source and Ectoin. the micro cluster water is the water with 17 O-NMR half peak width smaller than 80 HZ. The ion compounds include one of or any combination of calcium ion, magnesium ion, potassium ion, ferrous ion, zinc ion and copper ion. The vitamin includes one of or any combination of biotin, choline chloride, vitamin B12, folic acid and the derivant thereof, inositol and the derivant thereof, D-Panthenol and the derivant thereof, vitamin B3 and the derivant thereof, vitamin B6 and the derivant thereof. The amino acid includes one of or any combination of human essential amino acid and the derivant thereof, ornithine and the derivant thereof, glutathione and the derivant thereof. The carbon source includes one of or any combination of carbohydrates and sodium pyruvate.

Disclosed are compositions and methods for their use for reducing tumor necrosis factor alpha (TNF-) and/or vascular endothelial growth factor (VEGF) production in skin cells by topically applying to skin in need thereof, a composition comprising an effective amount of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or both, or extracts thereof, to reduce TNF- or VEGF production in skin cells.

The present disclosure provides at least one skin supplement composition that has been shown to be advantageous for healthy skin, preferably comprised of hydrolyzed collagen, glucosamine sulfate, biotin, vitamin A palmitate, vitamin E, alpha lipoic acid, coenzyme Q.sub.10, pine bark extract, L-selenomethionone and niacinamide. An advantageous nootropic composition is also disclosed preferably comprised of ascorbic acid, taurine, elemental magnesium, glycinate, L-theanine, L-tyrosine, pine bark extract, N-acetyl-L-carnitine, DL-choline bitartrate, maca root, glucosinolates, P5P (pyridoxal-5-phosphate) and alpha ketoglutaric acid. A method to provide a specifically tailored supplement is also disclosed, preferably of collecting dry blood spots, analyzing the dry blood spots with tandem mass spectrometry, determining an amino acid kinetic pattern based on the analysis, and generating the specifically tailor supplement based on the pattern.