A device and protective composition is described that is used in the context of first aid for skin contact with acids, bases, oxidizing agents, formaldehyde and fluorides serving to neutralize and inactivate the chemicals. The device comprises a two-chamber applicator that contains a first preparation in a first chamber, such as an antioxidant, and a second preparation in a second chamber, such as a solution that contains a buffer and a calcium salt. The two preparations are mixed just before application and are applied to the affected areas by the device.

In some embodiments, a formulation may include one or more of a lipid-soluble vitamin C compound, derivative, or analog, a cinnamic acid derivative, one or more lipid-soluble vitamin E compounds, and a lipid-based carrier. In some embodiments, the cinnamic acid may include one or more of p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, combinations thereof, and cis and trans isomers thereof. In some embodiments, the vitamin E compounds may alpha, beta, delta and gamma tocotrienols.

A method of reducing the appearance of fine lines or wrinkles or increasing skin elasticity or skin firmness is disclosed. The method can include topically applying to the fine line or wrinkle or to sagging or loose skin an effective amount of a topical composition comprising a combination of vegetable amino acids from navy bean, Myrciaria dubia fruit extract, Peucedanum graveolens extract, and tetrahexyldecyl ascorbate. The combination can reduce the appearance of the fine line or wrinkle, increases skin elasticity, or increases skin firmness.

The present invention is drawn, in part, to biocompatible compositions comprising a biocompatible polymer matrix and conditioned cell medium comprising i) a cell culture medium and ii) one or more agents synthesized by and secreted from one or more cells cultured in the cell culture medium, as well as therapeutic uses thereof, particularly in modulating bone and/or gum tissue growth.

Personal care topical compositions at skin-tolerant pH with cystine which is solubilized or has small crystal size below 20 microns. A process of making the composition is also described.

Disclosed herein are cosmetic compositions comprising Swertia chirata extract, hyaluronic acid, and retinoid, and a method of reducing fine lines and/or wrinkles, and/or smoothing the skin by topically applying the cosmetic compositions to the skin.

A cosmetic composition in the form of a direct oil in water creamy emulsion includes water and oily phases, the water phase including a salt-stable polymeric system that includes polyacrylate crosspolymer-6, xanthan gum, and one or more clay, and high amounts of Vitamin C, oils and emulsifiers and confers a pleasant feel upon application with a smooth, gliding texture and does not severely “pill,” “ball” or “noodle” when applied to the skin. The cosmetic composition does not phase separate into solid/liquid or oily and water based layers.

A method of lyophilizing exosomes using a cryoprotectant comprising methionine, mannitol and trehalose is disclosed. The lyophilized exosome product shows a good appearance which maintains a porous sponge shape without forming ice crystals. In addition, the lyophilized exosome product can be applied to a pharmaceutical composition, a skin external preparation and a cosmetic composition. For example, the lyophilized exosome product can be used as a solution obtained by simply mixing it with a diluent.

The present invention has objects to provide a novel crystalline 2-O-α-D-glucosyl-L-ascorbic acid and method for producing the same. The present invention solves the above objects by providing crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid and method for producing the same.

The present invention relates to a cosmetic process which applies onto the skin a self-standing cosmetic sheet for the skin, comprising: at least one biocompatible and/or biodegradable hydrophobic polymer layer wherein the self-standing cosmetic sheet has a thickness of from 10 to 1000 nm, preferably from 30 to 500 nm, and more preferably from 50 to 300 nm. The cosmetic sheet according to the present invention may comprise at least one cosmetic active ingredient. The cosmetic sheet used in the present invention is very thin and not easily perceived on the skin; can be prepared with a variety of materials such as a biocompatible and/or biodegradable material; and can adhere well onto the skin without any adhesive layer so that it is less irritable or no irritable to the skin.