Formulations such as serums to treat skin discoloration via a multi-modal approach are provided in some embodiments in which select ingredients work together to effectively brighten skin and treat hyperpigmentation.

A method for treating hair comprising applying primer(s) and cationic polymer(s) onto a user's hair for improving the styling of the hair in a more manageable and reliable manner and for enhancing the stability of the final style obtained.

A disintegrating oral tablet suitable for active pharmaceutical ingredients includes a population of particles and at least one flavor ingredient. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in a burst of the at least one flavor ingredient upon mastication of the tablet.

Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):

##STR00001## wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably tram); or —CR.sub.a═CR.sub.b— a stilbene derivative; where R.sub.a and R.sub.b are independently H or phenyl optionally substituted with —(R.sup.3).sub.p or —(R.sup.4).sub.q; R.sup.1 to R.sup.4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R.sup.1 to R.sup.2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

The present invention provides a preparation for attaching to teeth or tooth peripheries, which comprises a malleable oral composition and an active ingredient for intra-oral delivery. Further, the present invention provides a preparation for attaching to teeth or tooth peripheries, which comprises an oral composition in a hardening ointment-phase and an active ingredient for intra-oral delivery. The preparation of the present invention may give high adhesive force to the desired site in spite of gaps between teeth or curves of teeth. The preparation of the present invention having high adhesive force increases the time of adhesion to a target site in the oral cavity, and thus may be advantageous in achieving an intended effect.

Needleless injection system (150) for injecting a composition, the system (150) comprising and/or designed to receive a reservoir (102) containing a pressurized gas, notably stored in gaseous and/or liquefied form, the system (150) comprising conveying ducts (306; 306a; 306b), enabling the gas to be directed, first, towards the human keratin materials in order to cool said materials by means of the cold generated by an expansion of the pressurized gas and/or towards a surface (340) configured such as to capture the cold generated by an expansion of the pressurized gas and to transmit it towards the human keratin materials in order to cool the human keratin materials, and, second, towards a mechanism (308; 309; 10; 9) for propelling the composition into the human keratin materials using the gas pressure.

The present invention is directed colloidal microcrystalline compositions, particularly for suspending particles in low viscosity fluids, produced by co-attrition of a mixture of microcrystalline cellulose and at least a polysaccharide in the presence of acidic attrition aid; their preparation; and, products made therewith.

Disclosed is a method of preparing an encapsulated liquid composition comprising the steps: preparing a frozen shaped unit of a liquid composition; and forming a shell to encapsulate the frozen shaped unit. The shell is formed by, for example, an alginate gel. The method of the present invention is suitable to provide, for example, bigger capsules and/or shaped capsules even for liquid compositions with low viscosity.

Disclosed is an encapsulated liquid composition comprising a shell and the liquid composition contained inside of the shell, wherein the encapsulated liquid composition meets at least one of the conditions: the encapsulated liquid composition has other shapes than spherical shape; the encapsulated liquid composition contains 2 liquid compositions having different colors inside of the shell, and the 2 compositions form stripe, marble, and/or rainbow; and/or the encapsulated liquid composition contains smaller inner capsule, where in the smaller inner capsule is also an encapsulated liquid composition comprising a shell and the liquid composition contained inside of the shell, wherein the shell is formed by a material selected from the group consisting of alginate gel, carrageenan gel, chitosan gel, or mixtures thereof.