A61K8/738

Self-standing cosmetic sheet

The present invention relates to a cosmetic process which applies onto the skin a self-standing cosmetic sheet for the skin, comprising: at least one biocompatible and/or biodegradable hydrophobic polymer layer wherein the self-standing cosmetic sheet has a thickness of from 10 to 1000 nm, preferably from 30 to 500 nm, and more preferably from 50 to 300 nm. The cosmetic sheet according to the present invention may comprise at least one cosmetic active ingredient. The cosmetic sheet used in the present invention is very thin and not easily perceived on the skin; can be prepared with a variety of materials such as a biocompatible and/or biodegradable material; and can adhere well onto the skin without any adhesive layer so that it is less irritable or no irritable to the skin.

COSMETIC COMPOSITIONS COMPRISING A CYCLODEXTRIN HAVING A PARTICLE SIZE DISTRIBUTION
20220117875 · 2022-04-21 ·

Cosmetic compositions comprising at least one cyclodextrin which is at least partially present in the form of solid particles dispersed in a physiologically acceptable medium, that the cyclodextrin particles have a volume average size d(4,3), of less than or equal to 20 μm, more preferentially less than or equal to 12 μm, and most preferentially less than or equal to 8 μm, and a size distribution by volume, of which the characteristic diameters d(10), d(50) and d(90) are such that: a. the diameter d(10) is less than or equal to 5.0 μm, preferentially less than or equal to 2.5 μm, b. and the diameter d(50) is less than or equal to 15.0 μm, preferentially less than or equal to 10.0 μm, c. and the diameter d(90) is less than or equal to 30.0 μm, preferentially less than or equal to 25.0 μm.

EMULSIFYING COMPOSITION COMPRISING A WATER-IN-OIL EMULSIFIER AND A CYCLODEXTRIN OF SELECTED PARTICLE SIZE, CAPABLE OF PROVIDING AN OIL-IN-WATER EMULSION WITH IMPROVED SENSORY EFFECTS FOR COSMETIC USE
20220023162 · 2022-01-27 ·

The present invention relates to a sensory emulsifying composition, in particular for cosmetic use, capable of obtaining a liquid oil-in-water-type emulsion comprising at least one cyclodextrin in the form of solid particles, said particles having a volumetric average particle size d(4,3), measured by laser granulometry, of between 2 and 20 μm, preferably between 3 and 12 μm, and more preferably between 4 and 8 μm, and at least one emulsifier of natural origin selected from water-in-oil emulsifiers, having a hydrophilic-lipophilic balance (HLB) of less than 8.

EMULSIFYING COMPOSITION CONSISTING OF AN OIL-IN-WATER EMULSIFIER AND A CYCLODEXTRIN OF SELECTED PARTICLE SIZE, CAPABLE OF PROVIDING AN OIL-IN-WATER EMULSION WITH IMPROVED SENSORY EFFECTS FOR COSMETIC USE
20220023187 · 2022-01-27 ·

The present invention relates to a sensory emulsifying composition, in particular for cosmetic use, capable of making it possible to obtain an oil-in-water-type emulsion, comprising at least one cyclodextrin in the form of solid particles, said particles having a volume-average size d(4,3) measured by laser granulometry, of between 2 and 20 μm, preferably between 3 and 12 μm, and more preferably between 4 and 8 μm; and at least one emulsifier of natural origin selected from oil-in-water emulsifiers, having an HLB greater than or equal to 8, and most preferably greater than or equal to 9.

Formulation and process for modulating wound healing

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): ##STR00001## wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CR.sub.a═CR.sub.b— a stilbene derivative; where R.sub.a and R.sub.b are independently H or phenyl optionally substituted with —(R.sup.3).sub.p or —(R.sup.4).sub.q; R.sup.1 to R.sup.4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R.sup.1 to R.sup.2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

ANHYDROUS HYDROCOLLOID MATRIX COMPRISING HOMOGENEOUSLY DISTRIBUTED ENCAPSULATED THERAPEUTIC AGENTS
20230310338 · 2023-10-05 ·

Anhydrous hydrocolloid matrices contain one or more encapsulated therapeutic agents, including an acne agent and/or skin conditioning agent. The anhydrous hydrocolloid matrices are used as acne treatment dressings alone or in a laminate with a water-impermeable or semi-water impermeable backing and a release liner. The anhydrous hydrocolloid matrices are made using a premix of viscosity modifiers and hydrocarbon emollients and the one or more therapeutic agents, which are mixed via high shear mixing to form the premix. The resulting anhydrous hydrocolloid matrices include the one or more therapeutic agents which are encapsulated and homogeneously distributed therein.

Pharmaceutical composition for preventing or treating wound, comprising indirubin derivative as active ingredient

The present disclosure relates to a composition for preventing or treating wound. The composition according to the present disclosure contains, as an active ingredient, an indirubin derivative alone or one or more selected from a group consisting of an indirubin derivative, an Euodia sutchuenensis Dode extract, methyl vanillate, hesperidin and quercitrin, and thus can be used as a pharmaceutical composition capable of promoting wound healing and reducing scarring not only in a normal state but also in a diabetic state. Furthermore, since the composition exhibits excellent effects in healing diabetic wound as well as general wound, it can be usefully used as a pharmaceutical composition, cosmetic composition or food composition for alleviating, preventing or treating general wound or diabetic wound, or as a veterinary composition for treating diabetic wound.

DENTAL COMPOSITION COMPRISING CHELATOR AND BASE
20230149285 · 2023-05-18 ·

The present invention relates to non-toxic consumable compositions and formulations comprising chelator and base having synergistic effects on microbial metabolism and/or growth and/orpathogenic effectors and their use to promote and maintain health in mammals. The current invention also relates to non-toxic consumable compositions comprising more than one chelator and/or more than one base. The present invention further relates to methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used. The present invention relates to the synergistic compositions and methods of their use for maintaing health, promoting health and treating diseases.

Cyclodextrins as dental cleaning powders
20230149284 · 2023-05-18 ·

The invention relates to the use of a powder in a powder jet device for cleaning tooth surfaces by powder spraying, wherein the powder comprises cyclodextrin. The invention also relates to a process for cleaning tooth surfaces with a powder jet device, wherein the powder comprises cyclodextrin and the invention relates to a powder or powder mixture for use in a powder jet device, wherein the powder or powder mixture comprises cyclodextrin.

Emulsifying composition for cosmetic use for producing an O/W pickering emulsion and process for producing this emulsion

The application relates to an emulsifying composition, in particular for cosmetic use, allowing an oil-in-water emulsion (O/W) to be obtained, the emulsion comprising at least one cyclodextrin and at least one O/W emulsifier of natural origin with a hydrophilic-lipophilic balance value (HLB) of more than 8. The O/W emulsifier of natural origin can be selected from alkyl polyglucosides, mixtures of at least one alkyl polyglucoside and at least one fatty alcohol, and non-ethoxylated polyol fatty esters. The application also relates to a composition of the Pickering emulsion type, in particular for cosmetic use, containing the emulsifying composition according to the invention, and to the process for preparing such a composition of the O/W Pickering emulsion type, in particular at low temperatures.