A disposing method for an inlet pipe in a muffler that includes an outer shell, an inlet pipe, and a separating plate, the disposing method comprising: a first step of inserting the inlet pipe into the outer shell from an opening at one end of the outer shell; a second step of disposing the inlet pipe by moving the inlet pipe within the outer shell in a direction substantially orthogonal to the direction of insertion of the inlet pipe; and a third step of disposing the separating plate by inserting the separating plate into the outer shell from the opening at the other end of the outer shell.

An irrigation pipe assembly that utilizes a pipe that is made of a durable material, e.g., stainless steel or aluminum. During fabrication, the pipe is equipped with a plurality of components, i.e., a flange assembly, a truss mount, and an outlet, without drilling, welding, or the like. In this manner, a method of fabrication is provided that enables a plurality of components to be assembled to the pipe without compromising the integrity of the pipe material or treated surface so that galvanizing or painting is not required after the plurality of components have been fitted to the pipe.

The present invention provides systems, methods, and apparatus for a vacuum tool having a switchable plate, such that a common vacuum tool may be adapted with different plates. A switchable plate may form the entirety of the vacuum tool's material contacting surface or a switchable plate may form a portion of the material contacting surface. The vacuum tool is effective for picking and placing one or more manufacturing parts utilizing a vacuum force.

Fluid flow control devices comprise a body including a central aperture extending along a longitudinal axis therethrough and a plurality of channels extending from an outer sidewall of the body to an inner sidewall of the body. At least one first channel may intersect at least one other channel. Fluid flow control systems, methods of forming fluid flow control devices, and methods of flowing a fluid through a fluid flow control device are also disclosed.

An anti-siphon drainage device having a housing forming an internal chamber, an inlet and outlet ports part of the internal chamber and fluidly connected by a primary flow path. A valve seat is associated with the primary flow path, a sloped section extends from the valve seat, and a valve element disposed in the sloped section and can seat in the valve seat to restrict a fluid flow into the primary flow path from the inlet port. A secondary flow path can have an opening near the inlet port and an orifice near the outlet port. A regulator has an aperture to selectively open and close the opening of the secondary flow path. When the valve element is seated in the valve seat and restricting the fluid flow into the primary flow path, the fluid flows into the secondary flow path.

A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

A device for managing fluid is provided. The device includes: a drip chamber including: an inlet; and outlet; a check valve positioned between the inlet and the outlet, the check valve configured for managing fluid flowing between the inlet and the outlet; and an elastic element. The combination of the check valve and the elastic element limits the extent to which the one way valve may be opened by brief transient pressures appearing at the outlet of the drip chamber. This limiting effect improves the accuracy of fluid delivery in setups such as ‘piggyback’ or Secondary Mode infusions of two fluids using a single pump.

A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.

A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device.

A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.