It is intended to provide a drug, a quasi-drug, a dermatological preparation for external use, or a material to be contained to drugs, quasi-drugs, dermatological preparations for external use, food products, or the like which has an excellent UCP-1 expression-promoting action and promotes conversion of adipose to brown adipose (browning). The present invention provides a UCP-1 expression promoter comprising a PPAR activator and a Smad3 inhibitor in combination. The present invention also provides a UCP-1 expression promoter comprising a PPAR activator, a Smad3 inhibitor, and a 3 adrenaline receptor activator or a TGR5 activator in combination.

A Chinese herbal medicine formula and its preparation method are provided. The Chinese herbal medicine formula is made from the following raw materials in parts by weight: 8-12 parts of rose hydrosol, 1-3 parts of peppermint hydrosol, 28-42 parts of Chinese herbal medicine extract, 1-3 parts of chelated platinum ions, 1-3 parts of chelated selenium ions and 4-10 parts of composite antibacterial agent. The preparation method includes adding the rose hydrosol and the peppermint hydrosol to the Chinese herbal medicine extract to obtain a stock solution; diluting the stock solution to obtain a diluted solution; and adding the chelated platinum ions, the chelated selenium ions, and the composite antibacterial agent to the diluted solution, uniformly stirring to obtain the Chinese herbal medicine formula. The prepared Chinese herbal medicine formula can effectively kill bacteria, viruses, and fungi, has excellent killing effects, and will not cause harm to human body.

A Chinese herbal medicine formula and its preparation method are provided. The Chinese herbal medicine formula is made from the following raw materials in parts by weight: 8-12 parts of rose hydrosol, 1-3 parts of peppermint hydrosol, 28-42 parts of Chinese herbal medicine extract, 1-3 parts of chelated platinum ions, 1-3 parts of chelated selenium ions and 4-10 parts of composite antibacterial agent. The preparation method includes adding the rose hydrosol and the peppermint hydrosol to the Chinese herbal medicine extract to obtain a stock solution; diluting the stock solution to obtain a diluted solution; and adding the chelated platinum ions, the chelated selenium ions, and the composite antibacterial agent to the diluted solution, uniformly stirring to obtain the Chinese herbal medicine formula. The prepared Chinese herbal medicine formula can effectively kill bacteria, viruses, and fungi, has excellent killing effects, and will not cause harm to human body.

The present disclosure provides a composition for enhancing skin barrier and anti-inflammation, including an exosome isolated from Agastache rugosa as an active ingredient. Also provided is a method for skin barrier-enhancing and anti-inflammatory, including administering to a subject in need thereof an effective amount of exosomes, in which the exosome is isolated from Agastache rugosa.

The present disclosure provides a composition for enhancing skin barrier and anti-inflammation, including an exosome isolated from Agastache rugosa as an active ingredient. Also provided is a method for skin barrier-enhancing and anti-inflammatory, including administering to a subject in need thereof an effective amount of exosomes, in which the exosome is isolated from Agastache rugosa.

A dietary supplement comprises the ingredients: Fructus tsaoko (Tsaoko Fruit), Rhizoma polygoni cuspidati (Knotweed), Radix scutellariae (Skullcap), Rhizoma anemarrhenae (Know Mother Root), Cortex magnoliae officinalis (Magnolia Bark), Radix paeoniae alba (White Peony Root), Rhizoma atractylodis (Red Atractylodis), Herba agastaches/Pogostemonis (Patchouli), Semen armeniacae (Apricot Kernel), Fructus trichosanthis (Chinese Cucumber), Radix astragali (Mongolian Milk-Vetch), Radix angelicae sinensis (Female Ginseng), Flos lonicerae (Honeysuckle), and Radix glycyrrhizae (Licorice). These ingredients are dried and integrated into a tea, which is consumed by a person infected or possibly infected with a respiratory virus.

A dietary supplement comprises the ingredients: Fructus tsaoko (Tsaoko Fruit), Rhizoma polygoni cuspidati (Knotweed), Radix scutellariae (Skullcap), Rhizoma anemarrhenae (Know Mother Root), Cortex magnoliae officinalis (Magnolia Bark), Radix paeoniae alba (White Peony Root), Rhizoma atractylodis (Red Atractylodis), Herba agastaches/Pogostemonis (Patchouli), Semen armeniacae (Apricot Kernel), Fructus trichosanthis (Chinese Cucumber), Radix astragali (Mongolian Milk-Vetch), Radix angelicae sinensis (Female Ginseng), Flos lonicerae (Honeysuckle), and Radix glycyrrhizae (Licorice). These ingredients are dried and integrated into a tea, which is consumed by a person infected or possibly infected with a respiratory virus.

The Agastache rugosa extract or the isoagastachoside or crude polysaccharide fraction included in the extract according to the present invention can be prepared based on plants being domestically cultivated, and thus is advantageous in terms of time and cost, and can effectively inhibit the differentiation, growth, and bone resorption functions of osteoclast progenitor cells, thus increasing bone density and the like, and accordingly, can be effectively used for the prevention, amelioration, or treatment of diseases related to bone loss caused by differentiation into osteoclasts or excessive activity of osteoclasts. In addition, the active ingredient, which is a plant-derived natural substance, is safe due to fewer side effects on the human body compared to chemical drugs, and inhibits osteoclast progenitor cells independently of estrogen, and thus can be widely used in osteoporosis occurring due to various causes other than menopause.

The Agastache rugosa extract or the isoagastachoside or crude polysaccharide fraction included in the extract according to the present invention can be prepared based on plants being domestically cultivated, and thus is advantageous in terms of time and cost, and can effectively inhibit the differentiation, growth, and bone resorption functions of osteoclast progenitor cells, thus increasing bone density and the like, and accordingly, can be effectively used for the prevention, amelioration, or treatment of diseases related to bone loss caused by differentiation into osteoclasts or excessive activity of osteoclasts. In addition, the active ingredient, which is a plant-derived natural substance, is safe due to fewer side effects on the human body compared to chemical drugs, and inhibits osteoclast progenitor cells independently of estrogen, and thus can be widely used in osteoporosis occurring due to various causes other than menopause.

Provided in the present disclosure are a traditional Chinese medicine composition for treating novel coronavirus pneumonia, a preparation method, a detection method, and the use thereof. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 250-400 parts of Citri reticulatae pericarpium, 100-200 parts of Atractylodis rhizoma, 100-200 parts of Magnoliae officinalis cortex, 200-300 parts of Glycyrrhizae radix et rhizoma, 200-300 parts of Agastache rugosus, 200-300 parts of Acori tatarinowii rhizoma, 250-330 parts of Jujubae fructus, and 100-200 parts of Zingiberis rhizoma recens. Further provided in the present disclosure are a preparation method and a detection method for the traditional Chinese medicine composition.