The present invention relates to formulations made up from extracts from Ganoderma lucidum, rhizome of Coptis chinensis, Radix astragali, Nelumbo nucifera Gaertn, Chaenomeles speciosa, and Fructus Aurantii. Pursuant to the invention, the formulations are used to treat obesity and the biological sequelae of obesity including cholesterol levels and glucose levels. While not limited to any particular mechanism of action the formulations may assert their effects by altering gene expression, in particular, the expression of PPAR, FABP4, CPT1, UCP2, and AMPK.

Disclosed herein is a pharmaceutical composition for preventing, alleviating or treating neurodegenerative diseases. The pharmaceutical composition contains, as active ingredients, Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum. The pharmaceutical composition is prepared by a method including the steps of: mixing Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum to obtain a mixture, and extracting the mixture to obtain a mixture extract; filtering the mixture extract; concentrating the mixture extract; and drying the mixture extract.

Disclosed herein is a pharmaceutical composition for preventing, alleviating or treating neurodegenerative diseases. The pharmaceutical composition contains, as active ingredients, Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum. The pharmaceutical composition is prepared by a method including the steps of: mixing Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum to obtain a mixture, and extracting the mixture to obtain a mixture extract; filtering the mixture extract; concentrating the mixture extract; and drying the mixture extract.

The composition includes the following active components: component (1): at least one kind of honey-fried licorice root, licorice root, Dioscorea japonica Thunberg, jujube fruit, malt starch syrup, and ginseng root; component (2): at least one of wild turmeric, longan aril, zedoary root, Suberect Spatholobus stem, Luffa vegetable sponge, Sparganium rhizome, safflower, and Artemisia anomala; component (3): at least one of tea leaf, mentha herb, mulberry leaf, chrysanthemum flower, and Koushi; and component (4): at least two of ripe tangerine peel, Psoralea corylifolia fruit, Chaenomeles speciosa fruit, Piper longum, cinnamon twig, Perilla, ginger root, coriander, Allium fistulosum Linne, Zizyphi Spinosi Semen, Chinese arborvitae kernel, plantago seed, plantago herb, coix seed, corn silk, belvedere Fruit, Benincasa seed, knotgrass, snowbellleaf tickclover herb, cinnamon, processed ginger, fennel, Zanthoxylum fruit, Piper nigrum, Eleutherococcus senticosus Rhizome, and Artemisia leaf.

The composition includes the following active components: component (1): at least one kind of honey-fried licorice root, licorice root, Dioscorea japonica Thunberg, jujube fruit, malt starch syrup, and ginseng root; component (2): at least one of wild turmeric, longan aril, zedoary root, Suberect Spatholobus stem, Luffa vegetable sponge, Sparganium rhizome, safflower, and Artemisia anomala; component (3): at least one of tea leaf, mentha herb, mulberry leaf, chrysanthemum flower, and Koushi; and component (4): at least two of ripe tangerine peel, Psoralea corylifolia fruit, Chaenomeles speciosa fruit, Piper longum, cinnamon twig, Perilla, ginger root, coriander, Allium fistulosum Linne, Zizyphi Spinosi Semen, Chinese arborvitae kernel, plantago seed, plantago herb, coix seed, corn silk, belvedere Fruit, Benincasa seed, knotgrass, snowbellleaf tickclover herb, cinnamon, processed ginger, fennel, Zanthoxylum fruit, Piper nigrum, Eleutherococcus senticosus Rhizome, and Artemisia leaf.

A method of treating a glucose-6-phosphate dehydrogenase deregulated disorder in a subject in need thereof, the method involving administering a therapeutically effective amount of oleanolic acid or a conjugate salt thereof or prodrug thereof to the subject. The glucose-6-phosphate dehydrogenase deregulated disorder can be BCL2 associated athanogene myofibrillar myopathy, amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, or Alzheimer disease.

A method of treating a glucose-6-phosphate dehydrogenase deregulated disorder in a subject in need thereof, the method involving administering a therapeutically effective amount of oleanolic acid or a conjugate salt thereof or prodrug thereof to the subject. The glucose-6-phosphate dehydrogenase deregulated disorder can be BCL2 associated athanogene myofibrillar myopathy, amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, or Alzheimer disease.