Embodiments of the disclosure relate to compositions that stimulate the generation or regeneration of bone tissue, increasing the rate of bone healing or repair inducing the formation of osteoblasts, inducing the differentiation of mesenchymal stem cells, and the treatment of a disease or disorder in a subject.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

The present invention describes compounds that are safe, nontoxic, noncorrosive, and nonirritating and methods thereof that are antibacterial and antiviral (encompassing cancer as well or chemotherapy) for the prevention and treatment of individuals suffering from infectious diseases. The compounds of the instant invention can also be administered to those individuals who are in need of such therapy such as those who have thymus diseases or those who are old enough that the thymus gland does not function anymore (thymus involution). This method can also be employed in healthy subjects as a preventive measure against such infections. The method relies on administering to infected patient healthy whole blood or healthy plasma transfusion procured from healthy children where it is permissible by law (emphasis added) or from healthy adults ages 18 to 20 years. This as a result will endogenously regenerate the thymus gland via the process of thymopoiesis to produce mature T cells, which are the most important cells in adaptive immunity for combating bacterial and viral infections. The compounds of the instant invention can be those, but not limited to, hormones secreted by the thymus gland and their synthetic counterparts, a combination of them, their active compounds, their progenitors, and their stimulating and mediated compounds and their mixtures thereof all can be used in the instant invention.

The present invention describes compounds that are safe, nontoxic, noncorrosive, and nonirritating and methods thereof that are antibacterial and antiviral (encompassing cancer as well or chemotherapy) for the prevention and treatment of individuals suffering from infectious diseases. The compounds of the instant invention can also be administered to those individuals who are in need of such therapy such as those who have thymus diseases or those who are old enough that the thymus gland does not function anymore (thymus involution). This method can also be employed in healthy subjects as a preventive measure against such infections. The method relies on administering to infected patient healthy whole blood or healthy plasma transfusion procured from healthy children where it is permissible by law (emphasis added) or from healthy adults ages 18 to 20 years. This as a result will endogenously regenerate the thymus gland via the process of thymopoiesis to produce mature T cells, which are the most important cells in adaptive immunity for combating bacterial and viral infections. The compounds of the instant invention can be those, but not limited to, hormones secreted by the thymus gland and their synthetic counterparts, a combination of them, their active compounds, their progenitors, and their stimulating and mediated compounds and their mixtures thereof all can be used in the instant invention.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

In the present invention, the whole preparation process of the sustained-release microparticles is at normal or low temperature, which is highly advantageous for the preparation of a polymer-based composition from a high-temperature-sensitive drug, particularly a protein, nucleic acid and peptide drug, and the bioactivity of the active substance can be maintained to the greatest extent throughout the process compared to the disclosed technology; at the same time, the prepared sustained-release microparticles have an excellent sustained-release effect close to zero order, and the drug concentration is stabilized during the release, which overcomes the defects that the microparticles obtained by the conventional S/O/W process of pre-preparing the drug microparticles have no drug release in the earlier stage and a rapid release of the drug in the later stage; and in addition, the sustained-release microparticles have higher drug loading rate and drug encapsulation rate.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.