An ophthalmic composition comprising Indigo Carmine, or Indigo Carmine and Trypan Blue, for identification of intraocular structures and membranes within the eye, and methods of delivering and using the same, for surgical treatments of the eye, including glaucoma and cataract surgery.

The present disclosure describes methods of use of a composition comprising PARPi-fl to be administered to the oral cavity (e.g., via topical application to surfaces of the oral cavity) followed by imaging of the oral cavity for detection of squamous cell carcinoma of the oral cavity (e.g., in vivo, e.g., in a dental office setting or intraoperatively). The results disclosed herein show that topically applied PARPi-fl and subsequent intraoperative imaging of oral cavities can improve surgical removal of squamous cell carcinoma cells compared to healthy cells.

The present disclosure provides systems and methods for imaging-guided monitoring and modeling of retinal vascular occlusive conditions. An example integrated optical coherence tomography (OCT) and scanning laser ophthalmoscope (SLO) apparatus includes an OCT subsystem to acquire baseline OCT and OCT angiography (OCTA) volumes of a subject without dye before occlusion and subsequent OCT and OCTA volumes of the subject with dye after occlusion. The example apparatus includes an SLO subsystem including a laser controlled to adjust a laser to form a vascular occlusion at a location on a target vessel of the subject. The example apparatus includes a processor to process the OCT and OCTA volumes and feedback from the OCT subsystem and the SLO subsystem to determine a change in three-dimensional vasculature from before the vascular occlusion to after the vascular occlusion.

The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.

The present disclosure relates generally to dry inks for use in marking the eye prior to surgery and methods of applying the same to eye marking devices. Such inks can include various accepted inks for use on the eye that can be applied to a marking device using relatively fast-evaporating solvents. In this manner, the remaining ink composition can be precisely placed on the eye marking device, and desirably transfer to the marking surface of the eye without dissolving on the journey through the various membranes above the marking surface. Application methods may include use of charged ink particles that may be advantageously manipulated using magnetic fields to even more precisely place the dry ink on a marking device.

A contrast mixture with increased affinity and selectivity to neoplasms of the gastrointestinal tract, being of three components and consisting of 0.0005-0.01% by weight of low-molecular component, 0.05-6% by weight of high-molecular component and isotonic solution, wherein low-molecular component is a contrast substance, which is a colouring agent used in food industry and pharmacy and high-molecular component is a colloid modulator of velocity designed to decelerate diffusion of the contrast mixture into a tissue in such manner that the velocity of diffusion into healthy tissue of gastrointestinal tract and the velocity of diffusion into neoplasm tissue of gastrointestinal tract is different. In an embodiment, the colouring agent is the sodium and/or calcium salt of [4-(alpha-(4-diethylaminophenyl)-5-hydroxy-2,4-disulphophenylmethylidene)-2,5-cyclohexadiene-1-ylidene] diethylammonium hydroxide or 3,7-bis(Dimethylamino)-phenothia zin-5-ium chloride and the colloid modulator of velocity is a starch, pectin, agar-agar (agarose and agaropectins) and/or non-linearly branched amylopectins. A use of the contrast mixture for colour sharp distinction of the interface between healthy tissue and neoplasm tissue of gastrointestinal tract.

The present disclosure relates generally to dry inks for use in marking the eye prior to surgery and methods of applying the same to eye marking devices. Such inks can include various accepted inks for use on the eye that can be applied to a marking device using relatively fast-evaporating solvents. In this manner, the remaining ink composition can be precisely placed on the eye marking device, and desirably transfer to the marking surface of the eye without dissolving on the journey through the various membranes above the marking surface. Application methods may include use of charged ink particles that may be advantageously manipulated using magnetic fields to even more precisely place the dry ink on a marking device.

The present invention relates to an ophthalmic solution of lissamine green which has shown to be particularly stable over time and well tolerated by the eye. Therefore, the ophthalmic solution finds advantageous application in the diagnosis of corneal and conjunctival anomalies.

The invention relates generally to the use of dyes to enhance visualization of tissues and boundaries of openings in tissues during cataract surgery.

The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.