A lighting apparatus including a controller, an LED driver, and an LED luminaire including: a first light emitting unit for general lighting; and at least one of a second light emitting unit to cause production of vitamin D upon irradiation, a third light emitting unit to cause production of a cell activating substance upon irradiation, and a fourth light emitting unit to sterilize pathogenic microorganisms, in which the controller controls the LED driver to change a color temperature of the first light emitting unit in accordance with a change in a color temperature of sunlight, and to change an irradiance of light emitted from at least one of the second, third, and fourth light emitting units according to time, and the LED luminaire includes a greater number of the first light emitting unit than any of the second, third, and fourth light emitting units.

Described herein generally are sterilization devices that can allow sterilization of a subgingival area, periodontal pocket(s), and/or gum tissue. Methods of using these devices are also described.

A light source for emitting emitted light having an SPD comprising: (a) a plurality of light emitters including at least one violet solid-state emitter; (b) at least one phosphor; wherein said light emitters and said at least one phosphor being configured such that: at least 25% of the power within the SPD is in the range 390-420 nm, and the emitted light has a chromaticity which is within a Duv distance of less than 5 points from the Planckian locus.

A skin microbiota modulation device that includes a cold plasma assembly configured to generate a cold plasma stimulus including a partially ionized gas mixture and to interrogate a biological surface with the cold plasma stimulus; and a microbiota seeding assembly including one or more target species of micobiota, the microbiota seeding assembly configured to deliver the one or more target species of micobiota to the biological surface.

Methods and apparatus provide therapeutic electromagnetic radiation (EMR) for inactivating infectious agents in, on or around a catheter residing in a patient's body cavity and/or for enhancing healthy cell growth. Transmitting non-ultraviolet therapeutic EMR substantially axially along an optical element in a lumen of the catheter body and/or the catheter body. Through delivery of the therapeutic EMR to particular infected areas and/or areas requiring tissue healing. The inactivation of the major sources of infection in, on, and around catheters and/or enhance healthy cell growth around catheters is accomplished by utilizing controlled relative intensity and/or treatment region specific dosing of the therapeutic EMR emitted radially from the optical element. Specific embodiments of urinary catheters and peritoneal dialysis catheters are also disclosed.

Disclosed are compounds of general formula (I): ##STR00001##
and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

An oral irrigator includes a base having a pump mechanism, a reservoir housed within the base and fluidically connected with the pump mechanism. A handle with a jet tip is connected with an outlet from the pump mechanism to receive a pressurized fluid stream from the reservoir to direct a fluid at a surface inside an oral cavity. The oral irrigator also includes a radiant energy source and delivery system for directing radiant energy at a surface inside an oral cavity.

Disclosed in certain embodiments is a method of treating a pathogenic infection comprising (i) contacting a pathogen residing in the oral cavity and/or pharynx of a patient in need thereof with a photosensitizer and (ii) subjecting the photosensitizer contacted pathogen to a light source.

A whole-body or whole-room voluminous antiviral and antibacterial airborne disinfection system is disclosed which includes a sterilization chamber, including a nozzle disposed in the sterilization chamber, a tank disposed outside the sterilization chamber, the tank is adapted to hold a photosensitizer fluid of edible food dyes, a light source within the sterilization chamber adapted to flood the sterilization chamber with light; and a nozzle adapted to release the photosensitizer fluid aerosols and generate reactive oxygen species in a fog-like dispersion.

A solution for controlling mildew in a cultivated area is described. The solution can include a set of ultraviolet sources that are configured to emit ultraviolet and/or blue-ultraviolet radiation to harm mildew present on a plant or ground surface. A set of sensors can be utilized to acquire plant data for at least one plant surface of a plant, which can be processed to determine a presence of mildew on the at least one plant surface. Additional features can be included to further affect the growth environment for the plant. A feedback process can be implemented to improve one or more aspects of the growth environment.