A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by an arthroscopic means approach that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.

A system for the repair of a ruptured tissue is provided. Aspects of the invention include a repair device comprising a combination of a scaffold and graft attached by one or more sutures to one or more fixation devices and inserted into a repair site via arthroscopic equipment or an open surgical procedure. The system may be used to treat tissue injuries including ruptured ligaments, tendons, and cartilage.

Disclosed are products and methods for treating soft tissue injuries. The provided methods include the production of processed or cryopreserved microvascular tissue. Also provided are products and methods of using processed or cryopreserved microvascular tissue for the treatment of soft tissue injuries.

In a connective-tissue body according to an embodiment of the present disclosure, comprising a biological tissue including collagen, a fine surface layer formed more finely than the inside thereof is provided on the surface of the connective-tissue body.

Disclosed are products and methods for treating soft tissue injuries. The provided methods include the production of processed or cryopreserved microvascular tissue. Also provided are products and methods of using processed or cryopreserved microvascular tissue for the treatment of soft tissue injuries.

A ligament-derived graft is provided which comprises a portion of a ligament sample recovered from a mammalian donor and which has been cut approximately in half lengthwise, where the ligament derived graft has dimensions suitable for use in a surgical procedure to repair small to mid-sized, or less load bearing joints. Small joints for which the ligament-derived grafts may be used to repair, include, interphalangeal, metacarpophalangeal joint, scapholunate joint, and other joints. In some embodiments, the dimensions of the ligament-derived graft include a length of from about 50 mm to about 150 mm, and a width of from about 3 mm to about 20 mm. In some embodiments, ligament samples used to make the ligament-derived grafts are lateral or medial collateral ligaments. Methods of using such ligament-derived grafts include attaching one or more ligaments, at their ends, to bones on opposite sides of the joint being repaired, so that the ligament(s) extend across the joint. When two grafts are used, they may extend across the joint, either on the same or opposite lateral sides of the joint.

The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.

Devices used to repair ruptured tendons are described, particularly a tendon grasping device and devices for the application thereof and to the uses if these devices; the tendon grasping device is made of a suitable for surgery bio-compatible material, a series of curved elements connected sequentially to form a hollow deformable structure; in use each curved element surrounds the tendon and the structure deforms between a radially extended condition and a radially retracted condition, in which each curved element firmly surrounds the tendon by applying pressure around the tendon without penetrating it.

An object is to provide a dried amniotic membrane that promotes regeneration of a tendon and a tendon sheath when a tendon injury has occurred and that reduces loss of the motor function of fingers of upper limbs and lower limbs due to tendon adhesion as a novel regeneration material. As a means for resolution, a dry amniotic membrane is produced by performing a specific drying treatment, that is, during a depressurization operation in which a fresh amniotic membrane placed in a treatment tank is continuously heated by an infrared heater provided in the treatment tank, and the inside of the treatment tank is brought into a depressurized state; and a pressure recovery operation in which the pressure of the inside of the treatment tank in a depressurized state is raised slightly toward the atmospheric pressure, drying is performed while applying energy to water molecules present in the amniotic membrane by irradiating the fresh amniotic membrane with a microwave also from a microwave generator provided in the treatment tank. The dried amniotic membrane retaining of the cell and tissue structures by repeating the treatment of drying a plurality of times promotes regeneration of the motor function of fingers of upper limbs and lower limbs after tendon suture surgery and is useful as a regeneration material.

The present invention relates to methods for preparing bioscaffolds useful in the repair of tears. More specifically, the invention relates to a method of treating rotator cuff tear in a mammalian subject in need thereof comprising the steps of: (i) selectively expanding tenocytes in vitro in culture medium comprising insulin or a functional derivative and a glucocorticoid or a glucocorticoid-like molecule to produce a culture of expanded tenocytes; (ii) seeding a bioscaffold with said expanded tenocytes to produce a tenocyte seeded bioscaffold; and (iii) implanting said tenocyte seeded bioscaffold proximal to the rotator cuff tear. The present invention also relates to a bioscaffold comprising cells, wherein more than 80% of said cells are tenocytes.