A portable medical apparatus for cardiopulmonary aid to patients includes a transportable machine body that integrates an heater/cooler unit and an extracorporeal circuit for circulating the blood of a patient. The extracorporeal circuit includes a line for drawing venous blood from the patient, a line for returning arterial blood to the patient, a pumping unit for pumping blood along the extracorporeal circuit, a heat exchanger for thermoregulating blood in the extracorporeal circuit, and an oxygenator unit for blood oxygenation.

A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

Described herein are systems, devices, and methods for an extracorporeal, artificial, placenta. In some embodiments, an artificial placenta and amniotic bed system may comprise a control unit, a gas delivery unit, a gas exchange unit or membrane oxygenator, a fluids delivery unit, an amniotic fluid bed, and a human machine interface. In some embodiments, the artificial placenta and amniotic bed systems, devices, and methods described herein may improve survival rates and minimize long-term disabilities in preterm, gestational-age, newborns. In some embodiments, the extracorporeal systems, devices, and methods comprise an artificial network through which oxygen and nutrient-rich blood may flow into a fetus (residing in an amniotic fluid bed), while carbon dioxide and wastes may be removed, thus re-establishing a form of intrauterine placental circulation.

An extracorporeal blood treatment apparatus (1) comprising a control unit (10) connectable to a blood warming device (200). The apparatus (1) comprises: an extracorporeal blood circuit (100) and at least one infusion line (15, 21, 25) connected to the extracorporeal blood circuit (100). A control unit (10) is configured to execute the following procedure: receiving a first value representative of a desired blood temperature (T.sub.des) at an end (70) of a blood return line (7) configured to be connected to a venous vascular access of a patient (P); receiving at least a first signal relating to at least a flow rate (Q.sub.PBP, Q.sub.REP1, Q.sub.REP2) of an infusion fluid in the at least one infusion line (15, 21, 25); calculating a set point value of an operating parameter (T.sub.OUT; P.sub.w) to be imposed on the warming device (200) configured to heat a blood heating zone (H) of the extracorporeal blood circuit (100) in order to maintain the desired blood temperature (T.sub.des) at the end (70) of the blood return line (7). The set point is calculated based on input parameters comprising: at least the first value representative of the desired blood temperature (T.sub.des) and at least one selected in the group of: the first signal (Q.sub.REP1, Q.sub.PBP, Q.sub.REP2) and a second value representative of a temperature (T.sub.REP1, T.sub.PBP, T.sub.REP2) of the at least one infusion fluid in the at least one infusion line (15, 21, 25).

Described herein are systems, devices, and methods for an extracorporeal, artificial, placenta. In some embodiments, an artificial placenta and amniotic bed system may comprise a control unit, a gas delivery unit, a gas exchange unit or membrane oxygenator, a fluids delivery unit, an amniotic fluid bed, and a human machine interface. In some embodiments, the artificial placenta and amniotic bed systems, devices, and methods described herein may improve survival rates and minimize long-term disabilities in preterm, gestational-age, newborns. In some embodiments, the extracorporeal systems, devices, and methods comprise an artificial network through which oxygen and nutrient-rich blood may flow into a fetus (residing in an amniotic fluid bed), while carbon dioxide and wastes may be removed, thus re-establishing a form of intrauterine placental circulation.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

A medical treatment system, such as a peritoneal dialysis system, may include a control and other features to enhance patient comfort and ease of use. For example, a cycler device may include a heater bag receiving section and a lid mounted to cover and uncover the heater bag receiving section, potentially enabling faster heating of a dialysate. A user interface may be moveable to be received into the receiving section and covered by the lid, if desired. The system may detect anomalous conditions, such as tilting of a housing of the system, and automatically recover without terminating a treatment. The system may include noise reduction features, such as porting pneumatic outputs to a common chamber, and others. The system may also automatically detect any one of several different solution lines connected to the system, and control operation accordingly, e.g., to mix solutions provided by two or more lines and form a needed dialysate solution. A cassette control surface may be arranged to have one or more ports that can detect a presence of a liquid, e.g., to identify if a cassette is leaking or has otherwise been compromised.

A heat exchanger for an oxygenator device has multiple hollow fiber membranes that each have a hollow portion through which a heat medium passes, wherein the fibers are wound as a cylinder body. Each of the hollow fiber membranes follows a path between opposing ends of the cylinder body which is tilted with respect to a central axis of the cylinder body and is wound around the central axis of the cylinder body, wherein a tilt angle θ with respect to the central axis ranges from 22° to smaller than 67°, and wherein a constituent material of each of the hollow fiber membranes has a Young's modulus E ranging from 2.6 GPa to 0.07 GPa. During winding, the hollow fiber membranes are stretched according to a stretching rate between 0.5% and 3.0% and then fixed at the ends to maintain the stretching.

A heating system for medical fluid that comprises a receptacle for medical fluid to be heated, a heating element powered by a power supply inducing a leakage current (to ground) ranging between 100 and 10 μA. The heating system further comprises an interface device (for example, an electrical insulation and thermal interface device) disposed between the heating element and the medical fluid contained in the receptacle, allowing the heating system to induce a leakage current in the medical fluid that is less than 10 μA at the applied part.

A sorbent cartridge for use in a portable wearable renal therapy system, and a method of using same is provided. The sorbent cartridge comprises: a inlet and an outlet, the inlet configured to receive process fluid from renal therapy device and the outlet configured to discharge treated process fluid; a hydrogel configured to absorb and adsorb a toxin from the process fluid without use of a dialysate to purify the process fluid. The inlet and the outlet are each configured to releasably couple to the renal therapy device for removing the sorbent cartridge.