A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.

A renal therapy machine includes a blood filter including a plurality of porous fibers; a blood circuit in communication with the blood filter; and a dialysate circuit in communication with the blood filter and operable with at least one pump, wherein the renal therapy machine is configured to perform a priming sequence in which a physiologically compatible solution, other than dialysate, primes the blood circuit and is flowed within the fibers and through pores in the fibers of the blood filter, and the pump of the dialysate circuit vents air from the blood filter into the dialysate circuit.

Provided is a dialysate supply device and a blood dialyzing apparatus including the same. The dialysate supply device includes a flow controller controlling a dialysate flow, a supply pump supplying dialysate to a hemodialyzer, a recovery pump discharging dialysate from the hemodialyzer, a volume chamber storing dialysate, and a pressure-relief bypass maintaining dialysate pressure within a permissible range. The blood dialyzing apparatus includes the dialysate supply device, a blood tube, and a one-way valve disposed on the blood tube. The blood dialyzing apparatus can quickly change dialysate pressure in the hemodialyzer using the dialysate supply device having the flow controller, cylinder and piston, and increase mass transfer and hemodialysis efficiency. Also, the blood dialyzing apparatus may be miniaturized and lightened to provide a portable blood dialyzing apparatus because blood is transferred without using a blood pump.

A dialysis system includes a dialysis instrument including a blood pump actuator, a dialyzer, a heparin pump, and a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument, the blood pumping portion including an inlet and an outlet, the inlet of the blood pumping portion of the disposable cassette positioned and arranged to receive blood from an arterial line of an extracorporeal circuit, the outlet of the blood pumping portion of the disposable cassette positioned and arranged to deliver the blood to the dialyzer and to receive heparin from the heparin pump.

The present invention involves, in some embodiments, mechanisms and methods of occluding collapsible tubing with an occluder to prevent fluid flow therethrough. In some embodiments, a tube occluding mechanism is disclosed that includes a bendable occluding member for creating a force that can be applied to a collapsible tube to occlude the tube. In some embodiments, the collapsible tube can be an inlet/outlet tube on a removable pumping cartridge that is coupled to a reusable pump drive component when the system is in operation. In such embodiments, the occluding mechanism can be attached to the reusable component and can be used to block fluid flow to and from the pumping cartridge. In some embodiments, the occluding member can comprises a spring plate which can create a force to occlude tubing when in a relaxed, unbent configuration, and which can be bent to unocclude the tubing. In some preferred embodiments, in a default configuration of the tube occluder mechanism (when no external force is applied to the occluding member) the tubes are occluded, so that the tube occluder mechanism provides a fail-safe configuration preventing fluid flow to and from a pumping cartridge to which the tubes can be connected.

A medical fluid pneumatic manifold system includes a first plate including a plurality of apertures, a second plate attached to the first plate so as to form a plurality of pneumatic flowpaths sealed between the first plate and the second plate, a plurality of tubing connections and a plurality of pneumatic tubes connected to the plurality of tubing connections, the plurality of tubing connections placing the plurality of pneumatic tubes in pneumatic communication with the plurality of pneumatic flowpaths via the plurality of apertures of the first plate, and a pneumatic reservoir in pneumatic communication with the plurality of pneumatic flowpaths, the pneumatic reservoir configured to provide pneumatic pressure to the plurality of pneumatic tubes.

Provided is a dialysate supply unit and a blood dialyzing apparatus including the dialysate supply unit for supplying dialysate of a dialysate tank to a hemodialyzer and collecting dialysate passing through the hemodialyzer in an effluent tank. The dialysate supply unit includes a dialysate pump, an effluent pump, a first flow-blocking valve, a second flow-blocking valve, and a flow-blocking valve driver. The dialysate pump connects the dialysate tank and the hemodialyzer and the effluent pump connects the hemodialyzer and the effluent tank. The first flow-blocking valve alternately blocks a dialysate outflow tube connecting the hemodialyzer and the dialysate pump and an effluent inflow tube connecting the hemodialyzer and the effluent pump. The second flow-blocking valve alternately blocks a dialysate inflow tube connecting the dialysate pump and the dialysate tank and an effluent outflow tube connecting the effluent pump and the effluent tank. The flow-blocking valve driver drives the flow-blocking valve.

A medical fluid pneumatic manifold system includes a plurality of pump and valve chambers for controlling a flow of medical fluid, a header including a plurality of pneumatic passageways, each passageway in pneumatic communication with one of the pump or valve chambers, a plurality of electrically actuated pneumatic valves, and a plate defining a plurality of pneumatic apertures, wherein the header and the plurality of electrically actuated pneumatic valves are separately attached to the plate, such that each pneumatic aperture in the plate is placed in pneumatic communication with one of the plurality of pneumatic passageways of the header and one of the electrically actuated pneumatic valves.

An extracorporeal system for lung assist includes a system housing, which includes a blood flow inlet and a blood flow outlet and a fiber bundle housing movably positioned within the system housing. The fiber bundle housing includes a gas inlet and a gas outlet. A fiber bundle is in operative connection with the fiber bundle housing. The fiber bundle includes a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof. The system further includes an actuator to impart oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.

Provided is a dialysate supply device and a blood dialyzing apparatus including the same. The dialysate supply device includes a flow controller controlling a dialysate flow, a supply pump supplying dialysate to a hemodialyzer, a recovery pump discharging dialysate from the hemodialyzer, a volume chamber storing dialysate, and a pressure-relief bypass maintaining dialysate pressure within a permissible range. The blood dialyzing apparatus includes the dialysate supply device, a blood tube, and a one-way valve disposed on the blood tube. The blood dialyzing apparatus can quickly change dialysate pressure in the hemodialyzer using the dialysate supply device having the flow controller, cylinder and piston, and increase mass transfer and hemodialysis efficiency. Also, the blood dialyzing apparatus may be miniaturized and lightened to provide a portable blood dialyzing apparatus because blood is transferred without using a blood pump.