An endovascular apparatus comprises a catheter shaft constructed and designed for insertion into a venous vessel of a patient; a capture thread positioned in at least one lumen of the catheter shaft and extending from a proximal end of the catheter shaft to a distal end of the catheter shaft for capturing components of a bodily fluid from the patient, the catheter shaft including a plurality of ports for exposing the capture thread to the bodily fluid of the patient; and an enclosure coupled to the proximal end of the catheter shaft. The enclosure includes a feed vessel in communication with a first end of the capture thread and a collection vessel in communication with a second end of the capture thread; and a drive system that controls a movement of the capture thread in the catheter shaft from the feed vessel to the collection vessel.

A wearable mobile continuous ambulatory peritoneal dialysis (mCAPD) system, includes an mCAPD module mounted on a front portion of a wearable belt, wherein the mCAPD module comprises a micro-peristaltic pump disposed in a corresponding front portion, and an electronic control board connected to the micro-peristaltic pump for controlling and managing the mCAPD process, a fluid bag containing a dialysate fluid, attached to the wearable belt and to the electronic control board, and a sterile connector having a tube portion fixed into a guide section of the micro-peristaltic pump, and a first connecting end for connecting to a first tube inserted into a peritoneum cavity of the human body, and a second connecting end for connecting to a second tube attached to the fluid bag. Upon rotation, the micro-peristaltic pump enables a flow of fluid between the peritoneum cavity and the fluid bag.

To enhance diffusive mass transfer of small molecules and convective clearance of middle molecules, the present invention provides a cylindrical hemodialyzer which comprises a blood compartment having a packed bundle of hollow fibers in a doughnut configuration on a radial cross-section, and a motorized dialysate compartment comprising a dialysate inlet motor having an external stator and an internal rotor connected to an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers. The cylindrical hemodialyzer is configured to recirculate dialysate across the packed bundle of the hollow fibers propelled by the dialysate inlet motor. A dialysate outlet motor of the motorized dialysate compartment having an external stator and an internal rotor is configured to drain the dialysate and to control ultrafiltration by said cylindrical hemodialyzer.

To enhance diffusive mass transfer of solutes, the present hemodialyzer in a cylindrical configuration for hemodialysis comprises a blood compartment having a packed bundle of hollow fibers in a reversibly distensible doughnut configuration on a radial cross-section, and a dialysate compartment having an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers and an outer circumferential space encircling an outer circumferential layer of the packed bundle of the hollow fibers. The axial spiral flow converter is configured to convert an axial dialysate flow to a centrifugal dialysate flow radially spreading from the center of the packed bundle of the hollow fibers to the outer circumferential space of the hemodialyzer.

Methods and systems for the automated collection of plasma from a donor are disclosed. The methods and systems deliver anticoagulant to whole blood and/or to selected and separated components at selected times to provide a sufficient amount of anticoagulant to the selected components to prevent coagulation and/or flocculation. The methods and systems limit the amount of anticoagulant returned to the donor and maximize the amount of collected plasma. Methods and systems for maximize the collection of IgG based on a measured level of total plasma protein are also disclosed.

To enhance diffusive mass transfer of solutes, the present hemodialyzer in a cylindrical configuration for hemodialysis comprises a blood compartment having a packed bundle of hollow fibers in a reversibly distensible doughnut configuration on a radial cross-section, and a dialysate compartment having an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers and an outer circumferential space encircling an outer circumferential layer of the packed bundle of the hollow fibers. The axial spiral flow converter is configured to convert an axial dialysate flow to a centrifugal dialysate flow radially spreading from the center of the packed bundle of the hollow fibers to the outer circumferential space of the hemodialyzer.

Disclosed are example embodiments of a dialysis machine having a frame, a cartridge cassette, one or more alignment-locking features, and an actuation mechanism. The frame is fixedly coupled to the dialysis machine, and the cassette is slidably coupled to the frame. The cassette can have one or more track structures, with each of the one or more track structures having a rotor and one or more rollers. The one or more alignment-locking features extend from the frame and are configured to be inserted into one or more alignment features of a disposable cartridge that functions to secure or release the disposable cartridge. The actuation mechanism is made to slide the cassette with respect to the one or more track structures.

A computer-implemented method for controlling fluid flow rates during a biological fluid procedure, comprising providing a membrane separator configured to separate a biological fluid into filtrate and retentate, wherein concentration of retentate exiting the membrane separator is controllable by altering a flow rate of the retentate exiting the membrane separator. The computer-implemented method also comprises detecting a change of attenuated retentate particles within the filtrate, comparing the change of attenuated retentate particles within the filtrate with a threshold level, and providing a response action comprising altering the concentration of retentate exiting the membrane separator if the change of attenuated retentate particles within the filtrate exceeds the threshold level.

A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.

Provided is a therapeutic device that includes tubing; at least one pump; and a column or filter capable of removing leukocytes, cytokines, and/or other blood components from the blood of a patient to effectively treat or prevent post-resuscitation syndrome. Methods for treating and/or preventing post-resuscitation syndrome that include the use of such a device, or a filter or column capable of selectively removing inflammatory biomarkers, are also provided.