A device for infusion of medical fluids is provided. It has an internal reservoir for a fluid to be administered made of a first flexible base material to vary its volume as a function of the quantity of fluid present thereinside; and an outer casing containing the reservoir, having a side wall made of a second elastic base material suitable to make elastically deformable the casing to vary the geometry and internal volume thereof as a function of the volume of the reservoir.

According to an aspect, a cannula insertion mechanism includes a seal and a cannula carrier. The seal is configured to surround an opening of a housing, the seal including a first seal surface and a second seal surface, the first seal surface facing toward the opening, and the second seal surface facing away from the opening. The cannula carrier is configured to drive a cannula in a first direction through the opening of the housing, the cannula carrier having a first carrier surface and a second carrier surface, the first carrier surface being configured to exert a compression force on the second seal surface when the cannula carrier drives the cannula in the first direction, thereby causing the first seal surface to expand in a second direction to engage the second carrier surface via a clamping force.

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an interior surface defining an enclosed space, and an exterior surface releasably attachable to a patient. A container may be disposed in the enclosed space and include a reservoir containing a drug and a stopper. A drive assembly may also be disposed in the enclosed space and configured to move the stopper through the reservoir to expel the drug from the reservoir. The drive assembly may include a rotational power source and a gear module. The gear module may include a mounting plate and a plurality of gears rotatably connected to the mounting plate. Furthermore, the mounting plate may be separate from the main housing.

A bilaterally driven drug infusion device with multiple infusion modes comprises: a drug storage unit (150); a piston (160) and a driving wheel (130,630) respectively connected with a screw (170), the driving wheel (130,630), provided with wheel teeth (131,631), drives the screw (170) movement by rotation, the piston (160) is arranged in the drug storage unit (150), the screw (170) advances the piston (160) to move; a driving unit (100,200,300,400,500,600) cooperating with the driving wheel (130,630); and a power unit (180,680), connected to the driving unit (100,200,300,400,500,600), outputs forces in two different directions (A′,B′) on the driving unit (100,200,300,400,500,600) to lead driving unit (100,200,300,400,500,600) to perform multiple-mode operation, making the infusion device have multiple infusion increments or infusion rates. The driving unit (100,200,300,400,500,600) has a variety of different pivot amplitudes, that is, the driving unit (100,200,300,400,500,600) can realize multiple-mode pivot, thereby achieving increment-adjustable infusion.

A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

An insertion/retraction mechanism for a drug delivery device is disclosed. The insertion/retraction mechanism includes a retraction hub, an insertion hub, an insertion/retraction mechanism housing, and a dual torsion spring system. The retraction hub includes a first primary rotational stop and a second primary rotational stop extending radially inwardly from an inside surface. The insertion hub is disposed inside the retraction hub and comprises a first complementary rotational stop and a second complementary rotational stop extending radially outwardly from an outside surface. The dual torsion spring system causes the first primary rotational stop and the second primary rotational stop to selectively engage the first complementary rotational stop and the secondary rotational stop, respectively, and further causes the retraction hub to rotate relative to the insertion/retraction mechanism housing as the insertion/retraction mechanism moves between an initial position, an inserted position, and a retracted position.

A medicament delivery system for use with medicament delivery device includes a support member, a compression member spaced from the support member to define a gap therebetween, a mechanical coupling between the support member and the compression member comprising a plurality of connecting members extending between the support member and the compression member, and a biasing element connected to the compression member and configured to exert a rotational force on the compression member relative to the support member. The mechanical coupling is configured such that rotation of the compression member relative to the support member causes the compression member to be drawn towards the support member to reduce the gap therebetween.

A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir.

An automatic fluid injection device having a body fastened to a support. The body containing one or more fluid reservoirs, each containing an injection piston; a needle assembly including an injection needle; and an injection mechanism. The needle assembly including an injection needle and an insertion actuator made of a shape memory alloy. The needle assembly having a retraction ring; a needle support; an insertion ring; a retraction spring; an actuator ring; and an insertion spring. The insertion spring and the retraction spring retained, at rest, in their compressed state, activation of the actuator by heating to about 50% of the available contraction causing the needle support to be released, and activation of the actuator by heating to reach 100% of the available contraction causing the insertion ring and the assembly formed of the needle support and of the injection needle to be released.

MVO is treated by introducing injectate into blood vessels affected by MVO at precise flow rates, while blocking retrograde flow, such that the natural pumping of the heart aids in forcing the injectate into the affected microvessels. Monitoring pressure distal of an occlusion balloon is used to determine treatment effectiveness and heart health.