The present disclosure describes a system for the delivery of therapeutic substances to the cavities of a patient. The system can include a wearable micropump that is fluidically coupled with a handpiece. The handpiece can be inserted, for example, into the middle ear via a surgical tympanotomy approach. The system can enable a controlled injection of a therapeutic substance directly into the patient's cavity.

A drug solution administration unit including a drug solution administration module having a first flow path unit, a second flow path unit, and a drive mechanism unit, and a drug solution administration device having a branch path and a main path. The first flow path unit includes an upstream side main body where a first flow path to store drive solution is formed, and the second flow path unit includes a downstream side main body where a second flow path to store drug solution is formed. The drive mechanism unit includes a pair of electrodes and a porous body sandwiched between the pair of electrodes, the drive mechanism unit has a connecting flow path connecting a downstream end of the first flow path and an upstream end of the second flow path.

A system for delivering a medicinal fluid to a patient includes a variable volume pressure delivery chamber, a variable volume medication chamber, an optional medication reservoir, a movable delivery element, a fixed reference volume chamber, a pressure source, and a control sub-system. The variable volume pressure delivery chamber is configured to store pressure controllably. The variable volume medication chamber is fluidically isolated from the pressure delivery chamber and is configured to store medicinal fluid. The movable delivery element is disposed between the medication chamber and the pressure delivery chamber. The pressure source is coupled to the pressure delivery chamber. The control system is configured to selectively cause the pressure source to deliver pressure to the pressure delivery chamber causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber thereby causing the medicinal fluid to exit the medication chamber at an outlet along the fluid communication path to the patient.

Syringes are described herein. In certain embodiments, a syringe includes a syringe body, a movable plunger, and a biasing member. The syringe body defines a cavity and a port in fluid communication with the cavity. The movable plunger is disposed within the cavity. The plunger and cavity define a volume. The port is in fluid communication with the volume. The biasing member is coupled to the plunger. The biasing member is configured to urge the plunger toward the port to dispense a fluid stored within the volume at a desired rate.

A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.

Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.

A thrombectomy catheter system can include a catheter configured for insertion into vasculature of a patient. The system includes a pressure chamber configured to isolate an internal volume from a surrounding environment. The system can include an infusion container including an infusion fluid therein. The pressure chamber can receive the infusion container. A drive unit can pressurize a working fluid in the pressure chamber with the infusion container received in the pressure chamber. In an example, pressurizing of the working fluid correspondingly compresses the infusion container to pressurize the infusion fluid and transfer the infusion fluid to the catheter. In an example, the infusion fluid is isolated from the working fluid by the infusion container when the working fluid is pressurized in the pressure chamber.

Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.

A self-injection device with a miniaturized drug delivery portion is provided. The device includes a housing (10) having an interior volume and the drug delivery portion (20) has a volume enclosed within the housing. The drug delivery portion includes a reservoir (30) containing a fluid to be delivered to a user and a microneedle (22) in fluid communication with the reservoir and extendable through the housing. The drug delivery portion also includes a drive mechanism for expelling fluid from the reservoir through the microneedle, wherein the volume of the drug delivery portion is less than 40% of the interior volume of the housing. The volume of the drug delivery portion may be less than 30% of the interior volume of the housing.

Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.