A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. The distal end of the rolling diaphragm has a nozzle and a sidewall extending between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

The invention relates to a wearable injection device (1) for subcutaneous injection of a therapeutic agent, wherein the dose is injected over a specified period of time after the device is activated.

This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

A medical liquid infusion apparatus includes: a housing provided such that an interior thereof is at least partially open at a first time point and is sealed at a second time point later than the first time point; a needle assembly located in the housing and provided such that at least a portion thereof is discharged to an outside of the housing at a third time point later than the second time point by a user's operation; a reservoir that is sealed in the housing after the second time point, receives a medical liquid, and is fluidly connected to the needle assembly; a driving module that is sealed in the housing after the second time point, interposed between the needle assembly and the reservoir, and generates a driving force for discharging the medical liquid after the third time point; a battery module sealed in the housing after the second time point; and a control module that is sealed in the housing after the second time point, and electrically connected to a transmission module and the battery module after the third time point so as to control the driving module.

A substance delivery device is disclosed. The substance delivery device includes a lever that includes a drive arm that is rotatable about a pivot. The substance delivery device also includes a pump that has a deformable chamber. The deformable chamber is configured to rotate the drive arm about the pivot towards a container so as to deform the container to drive a fluid substance from the container.

This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

A system to be implanted in a living body for supplying medical substance, such as insulin. The system has a first module (1) having an inlet port (5) for receiving a transcutaneous injection of the medical substance, a second module (2) having a reservoir for storing the medical substance; a first tube (3) allowing the medical substance to flow between the first module and the second module; and a catheter (4) for releasing the stored medical substance into the living body. The first tube (3) allows the first module and second module to be implanted at different locations in the living body.

A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit.

A desired elution profile can be identified, and a delivery device designed to effect the desired elution profile, such as by selecting materials for the constituent components of the delivery device, designing a structure of the delivery device and its constituent components, and selecting a content of formulations, to provide for the designed elution profile at particular expected conditions or at particular times or both.

A medication infusion device includes a medication container containing liquid medication; an infusion needle; and a reciprocating pump having a pump chamber. The liquid medication is withdrawn from the medication container into the pump chamber during suction operation of the reciprocating pump, and the liquid medication is dispensed out of the pump chamber through the infusion needle during dispensing operation of the reciprocating pump. There are also mechanisms preventing liquid from flowing through the infusion needle during suction operation of the reciprocating pump and preventing liquid from flowing back into the medication container during dispensing operation of the reciprocating pump. The medication infusion device may further include a microcontroller to control medication infusion volume and rate.