Provided is a system for dispensing fluid. The system includes a housing defining a chamber; an inflatable bag disposed in the chamber and adapted to contain a fluid, the bag being in fluid communication with a flow path for flow of the fluid out of the bag; and a pressure source for inflating the bag to force the fluid from the bag to the flow path at a controlled rate. The bag inflates against an inner surface of the housing such that, prior to the bag being fully inflated, the fluid contained in the bag is forced from the bag at the controlled rate.

A system includes a drip chamber. The drip chamber has a proximal end coupled with a drug container and a distal end coupled with fluidic tubing. The drip chamber has a proximal check valve configured to prevent fluid flow in a proximal direction and to allow fluid flow in a distal direction when a cracking pressure threshold is overcome. The drip chamber also includes a distal check valve configured to prevent fluid flow in the proximal direction and to allow fluid flow in the distal direction when a cracking pressure threshold is overcome. The cracking pressure threshold of the proximal check valve and the cracking pressure threshold of the distal check valve in combination is greater than or equal to 1 PSId. The system also includes a pneumatic port between the check valves that is configured to pneumatically couple with a pneumatic feedback control system.

A system includes a drip chamber. The drip chamber has a proximal end coupled with a drug container and a distal end coupled with fluidic tubing. The drip chamber has a proximal check valve configured to prevent fluid flow in a proximal direction and to allow fluid flow in a distal direction when a cracking pressure threshold is overcome. The drip chamber also includes a distal check valve configured to prevent fluid flow in the proximal direction and to allow fluid flow in the distal direction when a cracking pressure threshold is overcome. The cracking pressure threshold of the proximal check valve and the cracking pressure threshold of the distal check valve in combination is greater than or equal to 1 PSId. The system also includes a pneumatic port between the check valves that is configured to pneumatically couple with a pneumatic feedback control system.

An auto-injector may include a housing having a longitudinal axis and a transverse axis, the housing having a shorter dimension along the transverse axis than along the longitudinal axis, wherein the transverse axis is perpendicular to the longitudinal axis; a flowpath having a first end and a second end; and a container enclosing a first fluid, the container extending from a first end toward a second end along or parallel to the longitudinal axis and being movable from a first position to a second position along or parallel to the longitudinal axis, the container being fluidly isolated from the flowpath in the first position and fluidly connected to the flowpath in the second position.

An auto-injector may include a housing having a longitudinal axis and a transverse axis, the housing having a shorter dimension along the transverse axis than along the longitudinal axis, wherein the transverse axis is perpendicular to the longitudinal axis; a flowpath having a first end and a second end; and a container enclosing a first fluid, the container extending from a first end toward a second end along or parallel to the longitudinal axis and being movable from a first position to a second position along or parallel to the longitudinal axis, the container being fluidly isolated from the flowpath in the first position and fluidly connected to the flowpath in the second position.

An apparatus for personal health maintenance has a sensor attached at least indirectly to a carrier member in turn attachable to a user or subject and configured for measurement of at least one physiological parameter of the user. A reservoir contains a preselected composition. An electronic processor is operatively connected to the sensor for receiving a signal therefrom encoding a measurement of the physiological parameter, the processor being configured for determining a divergence of the physiological parameter from a predetermined magnitude, the processor being operatively connected to a dispensing mechanism for ejecting, from the reservoir, an amount of the composition to be administered to the user to reduce divergence of the physiological parameter from the predetermined magnitude. The dispensing mechanism includes an expandable polymer composite layer with gas-filled micro-bubbles or microspheres expandable by operation of a heating element.

A controller controls a fluid pump to deliver primary fluid from a first source at a desired rate through a respective conduit to a recipient. The controller monitors a volume of the primary fluid injected into the conduit. Subsequent to injecting a predetermined amount of the primary fluid into the conduit, the controller i) discontinues injection of the primary fluid into the conduit and ii) injects a secondary fluid through the conduit to advance a remaining portion of the primary fluid in the conduit to the recipient. The controller advances the secondary fluid into the conduit until a desired amount of the primary fluid is delivered trough the conduit to the recipient. Injection of the secondary fluid to push the remaining portion of the primary fluid reduces waste associated with the primary fluid.

A controller controls a fluid pump to deliver primary fluid from a first source at a desired rate through a respective conduit to a recipient. The controller monitors a volume of the primary fluid injected into the conduit. Subsequent to injecting a predetermined amount of the primary fluid into the conduit, the controller i) discontinues injection of the primary fluid into the conduit and ii) injects a secondary fluid through the conduit to advance a remaining portion of the primary fluid in the conduit to the recipient. The controller advances the secondary fluid into the conduit until a desired amount of the primary fluid is delivered trough the conduit to the recipient. Injection of the secondary fluid to push the remaining portion of the primary fluid reduces waste associated with the primary fluid.

The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.

The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.