The present invention provides a microfluidic pump-based infusion anomaly state detection and control system, comprising: a microfluidic pump chip configured to control the vibration of an actuating device to output a liquid; a pressure sensor located in a pipeline behind the outlet of the microfluidic pump chip and configured to sense the change of the pressure of the liquid output by the microfluidic pump chip to output an electric signal; a signal conditioning circuit configured to perform signal conditioning on the electric signal to obtain a conditioned electric signal; a signal acquisition circuit configured to convert the conditioned electric signal from an analog signal into a digital signal; a signal processing unit configured to determine the working state of the microfluidic pump chip and the working state of an infusion pipeline according to the digital signal, and to send a signal to an alarming unit when an anomaly is found; the alarming unit configured to alarm according to the signal; and a control drive unit configured to adjust the output state of the microfluidic pump chip according to the output of the signal processing unit. The present invention can precisely control a microfluidic pump chip and accurately detect the anomaly state of the microfluidic pump chip and alarm in time.

The present disclosure relates to drug administration. In an exemplary embodiment, a system can include a drug administration device configured to dispense a drug to a patient, a monitoring device configured to log a delivery event of drug delivery from the drug administration device into the patient, and a sensor configured to sense a patient parameter following delivery of the drug into the patient. In another exemplary embodiment, a drug administration device can include a drug holder configured to hold a drug, a dispensing mechanism configured to dispense the drug, and a sensor configured to sense a patient parameter, and the drug administration device can be configured to locally activate the drug at a target location in the patient. In another exemplary embodiment, methods, devices, and systems are provided to assess when operation of a drug dispensing mechanism is complete and to confirm whether drug administration was successful.

A system and method is provided for detecting fluid low-volume and occlusion in a device using force sensing resistor (FSR) sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.

A medication delivery monitoring device is disclosed. The device includes a user interface configured to receive input information, and a sensor configured to measure a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by a vascular access device (VAD) to an infusion site region of the patient. The device also includes a processor configured to determine a state of the infusion site region based on the plurality of measured fluid state parameters and the input information, and an output device configured to provide a communication regarding the state of the infusion site region. Methods and computer-readable mediums for monitoring medication delivery are also disclosed.

A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.

Embodiments for protecting low-pressure blood pressure sensors in high-pressure fluid flow applications by equalizing pressure on both sides of a pressure sensor's diaphragm during high pressure are disclosed. A sensor protection device may include a pressure sensor assembly, a housing, and a plunger assembly. During low pressure, fluid in the primary flow path can flow through the housing, transferring its pressure to a first side of the diaphragm; the plunger assembly can prevent fluid flow into a secondary flow path in the housing, transferring atmospheric pressure to a second side of the diaphragm. During high pressure, fluid can still flow through the primary flow path, and the plunger assembly may now allow fluid flow into the secondary flow path, transferring pressure from the same fluid to the second side of the diaphragm to equal pressure across the diaphragm. The plunger assembly may automatically transition between low- and high-pressure configurations.

A medicament delivery device having a reservoir for holding a medicament, a pressurizing system that dispenses the medicament from the reservoir when operating, a hollow cannula for insertion into a patient, and a fluid delivery path disposed between the pressurizing system and the hollow cannula and communicating the medicament therebetween. The medicament delivery device also has a pressure sensor external to the pressurizing system, sensing a back pressure in the fluid delivery path, and providing an indication when the back pressure drops below a predetermined threshold after the pressurizing system ceases operation.

A system for infusing medication into a mammalian subject is provided. The system includes an injection system for controlling a flow of fluid from a fluid reservoir to a needle. A sensor is provided that detects a characteristic indicative of the fluid pressure in the needle. The injection system controls the flow of fluid to the needle in response to the characteristic detected by the sensor and the sensor continuously detects the characteristic as the needle is inserted into the subject. The system further includes a conductive element for providing electric nerve stimulation, wherein the system provides electric nerve stimulation in response to the sensor detecting a pressure exceeding an upper limit.

A method of pressure management of a drug delivery device including a pump, a fluid line, and a power source, includes: actuating the pump a predetermined number of cycles to move fluid through the fluid line, wherein the predetermined number of cycles is greater than one; determining an estimated pressure value within the fluid line for each cycle of the predetermined number of cycles; and determining a baseline pressure level comprising an average of the estimated pressure values.

A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.