A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.

In some examples, a medical dispensing device includes a housing and a trigger. A first engager of the device is configured to move axially as the trigger pivots. As the first engager moves, it engages a rod. A maximum proximal position of the rod is defined by a stop. A spring presses the first engager into the trigger such that either the trigger or the first engager rests against a stop limiting rotation of the trigger. A second engager moves axially as the trigger pivots. At the actuated position the second engager, defined by a stop, the second engager limits proximal movement of the rod. An assembly transfers movement of the trigger to the second engager after the trigger has pivoted a threshold amount. A member of the assembly distally moves the second engager. Until it is at the actuated position, the second engager enables the rod to proximally move.

The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rota-tion with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, moving the variable volume drug reservoir proximally relative to the housing to a completely mounted position, and shifting the piston rod guide irreversibly to a second state in which rotation of the piston rod guide in the second direction relative to the housing is prevented.

A drug delivery device comprises a housing (201) and an expelling assembly with a piston rod (220), a drive tube (260) with an outer surface and a scale drum (270) arranged between the drive tube and the housing, the scale drum being coupled to the housing and the drive tube outer surface. The device further comprises a drive spring (255) arranged between the housing and the drive tube, and setting means (280) allowing a user to simultaneously set a dose amount to be expelled and strain the drive spring correspondingly by rotation of the drive tube. The scale drum is coupled to the drive tube via a spline connection, wherein the drive spring is arranged proximally of the spline connection when the spline connection is in its proximal-most position.

An automatic injection device including a generally cylindrical syringe body having an opening, an outlet and an inner cylindrical surface adapted to contain an injectable liquid to be injected at an injection site via the outlet; a piston disposed in the cylindrical syringe body; a driving assembly, including an elongate plunger element having a forward end adapted to be axially inserted into the generally cylindrical syringe body and an at least partial forward sealing element mounted onto the elongate plunger element adjacent the forward end for creating an at least temporary slidable seal between the elongate plunger element and the inner cylindrical surface, whereby axial insertion of the elongate plunger element and the forward sealing element into the generally cylindrical syringe body creates friction between the forward sealing element and the inner cylindrical surface and also creates an at least temporary air spring between the forward sealing element and the piston, wherein the friction and the air spring dampen motion of the elongate plunger element.

Systems, devices, and methods for intradermal or subdermal fluid delivery via a microneedle are provided. A delivery system can include an injector, fluid-filled cartridge or syringe, and a needle. A cartridge or syringe can be compatibly coupled with an injector device such that the injector device is capable of ejecting fluid out of the cartridge and though the needle. Fluid delivery systems can be utilized in a number of applications, including medications and supplements for the skin.

A drug delivery device adapted to receive a cartridge and comprising a housing, an expelling assembly with a threaded piston rod, a threaded nut and a drive element arranged in non-rotational engagement with the piston rod, a drive coupling actuatable between a resetting state in which the piston rod can be moved proximally, and an operational state in which the drive element can drive the piston rod distally, wherein the drive element and the threaded nut are not moved axially relative to the housing when the drive coupling is actuated.

The present disclosure relates to a drug delivery device for dispensing of a liquid medicament, the device comprising:

a housing to accommodate a cartridge filled with the medicament and having a piston slidably displaced inside the cartridge along an axial direction and sealing a proximal end of the cartridge, a drive mechanism having a piston rod extending along the axial direction and being at least displaceable from a proximal end position in distal direction to displace the piston in distal direction, at least one distal support facing in proximal direction to axially abut a distally facing support face of the cartridge, wherein an axial distance between the distal support and a distal end of the piston rod when in the proximal end position is smaller than an effective length of the cartridge, which effective length is determined as the axial distance between a proximal face of the piston and the distally facing support face.

An injection device (100) for injection of a medicament from a pre-filled container (10) having a container body (12) for containing the medicament, a needle (16) disposed at a distal end of the container body (12), a removable needle shield (30) and a stopper (22) for expelling medicament from the container (100), the device comprising a housing (110) for housing the container (10), a plunger (142) for driving the stopper (22) of the container (10) in a distal direction to expel the medicament, and a priming mechanism having an operating member (152) which is movable with respect to the housing (110). The priming mechanism is arranged to release the needle shield (30) from the needle (16) and to move the container body (12) in a proximal direction with respect to the plunger (142) upon movement of the operating member (152) from a first position to a second position during an operating sequence of the device.

The housing for mounting an elongate-shaped container on an injection pen comprises an elongate-shaped body which extends along a longitudinal axis (X30) and which defines an interior volume (V32) for fully receiving the container. The body is provided, on the outside of a first axial end, with at least one first mechanical member for attaching a needle. The body is further provided, in the vicinity of a second axial end opposite the first axial end, with at least one second mechanical member for attaching the housing onto an injection pen. The housing further comprises, in the vicinity of the first axial end thereof, at least one third mechanical member for irreversibly locking a container in position, fully contained in the interior volume (V32) of the body of the housing. Said third locking member is formed by an elastically deformable tab intended to ensure locking of the container in position in the interior volume (V32) of the body of the housing, by axially retaining a flange of the container.