A package comprising a container for holding a first substance, and a product insert for holding a second substance, at least partially inserted info said container, and where the first product and the second product can be allowed to merge by external manipulation of said package. Packaged products and methods are also provided.

An article including either a frame having an interior cavity, and a flexible liner situated within the interior cavity; or a deformable frame having an interior cavity. Either frame can receive a sample, such as liquid having suspended live cells, and cooling freezes the sample to a solid sample. The solid sample can be readily ejected from the article having either a frame with the flexible liner, or the deformable frame, without extensive thawing. The solid sample can be rapidly displaced from the article.

A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

An auto-injector apparatus includes a flexible container containing a liquid medicant, a needle communicated with a container, a housing with a container being received in the housing, pump disposed in the housing and positioned to engage the flexible container and expel the medicant from the container through the needle upon relative movement between the pump and the container, and a main drive spring operably associated with the needle to extend the needle from a first needle position wherein the needle completely received in the housing to a second needle position wherein the needle protrudes from the using. The pump may be a roller.

The present disclosure relates to a container for a liquid medicament, comprising at least one flexible casing forming at least one cavity configured to receive the medicament, wherein the casing comprises a first wall portion and a second wall portion, wherein the second wall portion is located opposite to the first wall portion, at least a first outlet in fluid connection with the cavity and extending through the casing and multiple filaments extending through the cavity wherein each of the multiple filaments comprises a first end and a second end, wherein the second end is opposite to the first end, and wherein each of the first ends of the filaments are connected to the first wall portion and each of the second ends of the filaments are connected to the second wall portion.

A plunging unit for a syringe is provided comprising (i) a plunger comprising a plunger head connected to a thumb rest by a shaft; and (ii) a pusher housing comprising a finger rest and an internal channel connecting a plunger-receiving end of the housing to a barrel-receiving end of the housing, wherein the plunger-receiving end is adapted to receive the plunger head into the channel and the barrel-receiving end is adapted to engage a barrel of a carpule housing unit. The plunging unit includes an aspirator comprising an actuator connected to a spring-loaded piston that is situated within the pusher housing, wherein the actuator is adjacent to the plunger-receiving end of the pusher housing such that the shaft of the plunger is moveable through the actuator and the spring-loaded piston, the actuator being moveable between a resting position and an activated position in which the actuator is pushed downwardly against the bias of the spring-loaded piston to engage with and push a carpule forward within the carpule housing unit.

A syringe rolling apparatus for initial rolling of a rolling diaphragm syringe from an unrolled state to a rolled state has a pressure jacket configured for receiving an empty, unrolled rolling diaphragm syringe, a piston reciprocally movable within the pressure jacket and configured for contacting an end wall of the syringe rolling diaphragm syringe to initiate a rolling of a flexible sidewall of the rolling diaphragm syringe, and a seal assembly configured for engaging an open discharge neck of the rolling diaphragm syringe. The seal assembly is in fluid communication with a source of pressurized fluid to pressurize an interior of the rolling diaphragm syringe during a distal movement of the piston. A method for initial rolling of a rolling diaphragm syringe from an unrolled state to a rolled state is also disclosed.

A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

A needle housing having a distal end which is removably connectable to a source of injectable fluid and a proximal end for contacting a patient. The needle housing comprises (a) a hollow needle having a proximal end for insertion into body tissue of the patient, and (b) a chamber having an open proximal end, the chamber surrounding at least part of the needle and extending proximally beyond the proximal end of the needle to the open proximal end. The open proximal end of the chamber is deformable and moveable relative to the needle from a position in which the chamber extends proximally beyond the proximal end of the needle to a position in which the proximal end of the needle extends proximally through the open proximal end of the chamber.

A medicant injection device includes a compressible body, a tip, and an outer luer body. The compressible body has a proximal end, a distal end, and a plurality of bellows, and defines an inner cavity for holding a liquid medicant. The tip is positioned at the proximal end of the compressible body. The outer luer body includes internal threads, and is positioned over and engaged with the tip to form a first fitting therewith. The first fitting is configured to be connected with a second fitting. A medicant injection device includes a compressible body having first and second arms, a receptacle interconnected with the compressible body and defining an inner cavity, and a first fitting configured to engage a second fitting. The compressible body is configured to be compressed by forcing the distal end of the first and second arm toward each other.