A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge.

An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

A medicament injection device including a needle, a first stage that controls positioning of the needle at a depth into an animal when the device is pressed against the animal, and a second stage that injects the medicament through the needle into the animal after the needle is positioned at the depth and the device is further pressed against the animal. The device preferably includes a mechanism that permits the second stage to inject the medicament only after the needle is positioned at the depth. The depth of the needle preferably is adjustable, as is the amount of the medicament injected. In preferred aspects, these two features are independently adjustable. One or more springs, pneumatics elements, or other elements may automatically reset the first stage, the second stage, or both after the device is withdrawn from the animal. Also, associated methods.

The present invention relates to a drug delivery device comprising a drug container having at least one bellow. The at least one bellow has a first surface and an opposing second surface. The first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring.

A single use injector is a disposable injection device that is specifically optimized for production using the blow fill seal (BFS) manufacturing process and includes various mechanisms that render the device inoperable and facilitate its safe disposal after use. The single use injector incorporates an ampoule aseptically filled with a medication that is coupled to a hermetically sealed component system. The hermetically sealed component system incorporates various mechanisms that are actuated during the use of the injection device. The injection device is encased in a removable overtube that prevents contamination. upon removal of the overtube, the injection device is activated, by compression of a needle cap that irreversible punctures the ampoule in order to inject the medication through a needle. The injection device additionally incorporates a shield that deploys over the needle following injection of the medication into a patient.

A delivery device for delivering liquid from a flexible container is presented having a housing having a first wall provided with a housing first linear gear having housing first linear gear teeth, the housing being configured to receive the flexible container, a first roller having a first compound gear having a first gearwheel provided with first gearwheel teeth and a second gearwheel provided with second gearwheel teeth, and an actuator comprising an actuator first linear gear provided with actuator first linear gear teeth, wherein the first gearwheel teeth are configured to mesh with the housing first linear gear teeth and the second gearwheel teeth are configured to mesh with the actuator first linear gear teeth, wherein the actuator is configured to be moved linearly from a first position to a second position along a longitudinal axis defined by the longitudinal extension of the housing first linear gear.

A medicament delivery device is disclosed having a front assembly, and a rear assembly configured to be attached to the front assembly, wherein the front assembly has a front body and a syringe holder arranged in the front body, wherein the rear assembly has a rear body provided with a plunger rod, wherein the front body is configured to move axially relative to the rear body to enable the plunger rod to move forward inside the syringe holder, wherein the front assembly and the rear assembly are configured to be attached by means of a bayonet connection.

A device for reconstituting a bioactive agent and forming a flowable paste is described. The device comprises a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.

Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge.