A cartridge for dispensing a material, having: a sleeve having a longitudinal axis and a distal wall with a dispensing hole; a barrel defining a chamber for the material, including a proximal open end and a breakable distal wall at its distal end, and being movable in the sleeve between a first position where its distal wall is a distance from the sleeve's distal wall and a second position where its distal wall's sealing portion contacts an inner surface of the sleeve's distal wall; and a piston having a plate movable to seal the barrel's chamber. The sleeve includes an internal piercing element, near the dispensing hole, for breaking the barrel's distal wall upon moving the barrel from the first to the second position. Around the piercing element is an annular cavity delimited peripherally by a beveled inner surface that complements a beveled outer surface of the barrel.

A double walled container for a manually operated discharger includes a compartment for a fluid and a longitudinal axis. The compartment is configured to be sealed off by at least one wall of the compartment, the at least one wall at least regionally peripherally extending around the longitudinal axis and by a seal at a front end of the container.

A discharger for discharging fluid includes a sleeve, a discharge section, a carriage including a receiving space disposed therein, the carriage cooperating with a proximal end of the sleeve such that the carriage is moveable relative to the sleeve, and a piercing tip having a flow channel configured to establish a flow connection for the fluid from the receiving space to an inlet of the discharge section, the piercing tip having a shell surface, the piercing tip being integrally formed with at least a portion of the sleeve or formed as a unitary separate piece linked with at least the portion of the sleeve, the shell surface of the piercing tip having a convexly curved configuration, and the sleeve surrounding a proximal end of the discharge section and having an outer diameter that is substantially the same as the inner diameter of the carriage.

A discharger for discharging a predetermined amount of fluid includes a housing defining a longitudinal first axis and having a proximal end and a distal end, a discharge section having a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section, a carriage cooperating with the proximal end region of the housing such that the carriage is moveable relative to the housing along the first axis, the carriage including a receiving space for the fluid, and a piercing tip having a flow channel for establishing a flow connection for the fluid from the receiving space to the inlet opening of the discharge section, the piercing tip defining a centrally extending longitudinal second axis and having a shell surface. The shell surface of the piercing tip has an essentially convexly curved.

A kit for the direct use of a variety of medical ampoules of differing sizes, with a syringe, the kit having: a syringe body; a syringe plunger having a hollow interior volume; and a plurality of ampoule interface elements, each one being interchangeably received within the hollow interior volume and configured for deployment between an outer surface of the medical ampoule and a surface of the hollow interior volume so as to hold the medical ampoule therein, each of the plurality of ampoule interface elements having an outside diameter sized to fit an inside diameter of the hollow interior volume, wherein a first of the ampoule interface elements has an inside diameter for receiving a medical ampoule of a first size, and a second of the ampoule interface elements has an inside diameter different from the first inside diameter for receiving a medical ampoule of a second size.

An injection device having a drive member with first and second gear patterns that are fixed relative to each other. The drive member is rotatable and translatable in first and second opposing axial directions. A plunger expels medicament from a cartridge when it is translated in an advancing direction. A dosage indicator indicates a set dosage. A first gearing arrangement operably couples the first gear pattern with the plunger wherein rotation of the drive member in a first direction translates the drive member in a first axial direction without movement of the plunger and translation of the drive member in the opposite axial direction drives the plunger in the advancing direction. A second gearing arrangement operably couples the second gear pattern with the dosage indicator and moves the dosage indicator to indicate an increase in the set dosage when the drive member is translated in the first axial direction.

A kit for the direct use of a variety of medical ampoules of differing sizes, with a syringe, the kit having: a syringe body; a syringe plunger having a hollow interior volume; and a plurality of ampoule interface elements, each one being interchangeably received within the hollow interior volume and configured for deployment between an outer surface of the medical ampoule and a surface of the hollow interior volume so as to hold the medical ampoule therein, each of the plurality of ampoule interface elements having an outside diameter sized to fit an inside diameter of the hollow interior volume, wherein a first of the ampoule interface elements has an inside diameter for receiving a medical ampoule of a first size, and a second of the ampoule interface elements has an inside diameter different from the first inside diameter for receiving a medical ampoule of a second size.

Container assemblies for accommodating pharmaceutical compositions are provided. The container assembly includes a container and a plunger. The container has a hollow cylindrical body with an open end and a closed end, which is closed by a bottom portion. The hollow cylindrical body has a length (L), an outer diameter (DO), and an inner diameter with a length to outer diameter ratio between 3:1 and 15:1. The hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material. The container has an inner surface with an average Zn-leachability of 0.00085 g/cm.sup.2 or less. The plunger is inside the hollow cylindrical body at the open end, is pierceable by a cannula, and is slidable relative to the hollow cylindrical body from the open end towards the closed end.

An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains a medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.

A wearable injection device for subcutaneous injection of a therapeutic agent, wherein the dose is injected over a specified period of time after the device is activated.